Treatment of Periodontitis and Inflammatory Changes in Diabetes

牙周炎和糖尿病炎症变化的治疗

基本信息

批准号：
7809622
负责人：
HATICE HASTURK
金额：
$ 6.56万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-01 至 2010-10-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7809622
关键词：
Academic Medical Centers Affect Anti-Inflammatory Agents Anti-inflammatory Area Arts Aspirin Award Bacteria Biochemical Biopsy Specimen Blood Glucose Boston Caring Cells Characteristics Cholesterol Chronic Clinic Clinical Clinical Research Clinical Trials Collaborations Community Healthcare Comorbidity Complications of Diabetes Mellitus Data Data Analyses Dental Development Development Plans Diabetes Mellitus Dinoprostone Disease Effectiveness Effectiveness of Interventions Elements Exhibits Exposure to Five-Year Plans Foundations Funding Future Generations Gingiva Gingival Crevicular Fluid Glycosylated Hemoglobin Goals Hand Health Health Personnel Healthy People 2010 Hemoglobin concentration result Infection Inflammation Inflammation Mediators Inflammatory Inflammatory Response Interdisciplinary Study Interleukin-10 Interleukin-6 Intervention Studies Knowledge Lead Leukotriene B4 Life Lipids Lipoxins Literature Maintenance Therapy Master&apos s Degree Medicine Mentored Patient-Oriented Research Career Development Award Mentors Metalloproteases Mouth Diseases Oral Oral health Outcome Pathogenesis Patients Periodontal Diseases Periodontal Infection Periodontitis Phagocytes Preparation Principal Investigator Process Production Prospective Studies Public Health Quality of life Reporting Research Research Personnel Research Project Grants Risk Risk Factors Role Serum Severities Structure Superoxides Systemic disease Time Tissue Sample Tissues Training Training Programs United States National Institutes of Health Universities Work adiponectin base career development cohort cytokine design diabetic diabetic patient experience glycemic control health disparity improved inflammatory marker interest lipid mediator medical schools migration monocyte neutrophil patient oriented research peripheral blood prevent programs prospective research study response skills therapy development

项目摘要

DESCRIPTION (provided by applicant): The Mentored Patient-Oriented Research Career Development Award (K23) will provide protected time, at 75%, for the principal investigator to develop independent research expertise in the design, conduct, and analysis of patient- oriented research in dental medicine. The proposed career development plan basis on the candidate's interests and previous training and experience in periodontology and systemic diseases and clinical investigations. The five-year plan is designed to lead to the candidate receiving the degree of Master of Arts, in the area of Clinical Investigations, from the Boston University School of Medicine and to provide her with experience of conducting independent research program in the field of clinical research. The career development plan proposes an initial period of didactic work, together with a supervised research experience involving a prospective, interventional clinical research study of diabetes and periodontal infections, in the proposed five-year award period. The formal training in clinical investigation and the supervised research program will provide the candidate with the preparation needed to carry out her proposed research project involving a periodontal health intervention study in a cohort of patients with diabetes being followed at Boston University Medical Center and BostonNet Health Centers. The candidate will be mentored by experienced investigators who have a successful track record of guiding the work of research trainees. This K23 program will take a full advantage of active research collaborations, and provide the candidate with a broad exposure to patient-oriented research. In turn, these existing patient-oriented research projects, funded by the NIH, and corporate and foundation sponsors, will benefit by the ability to involve the candidate in these programs. The principal investigator will have the opportunity to build on existing research projects in the area of periodontal health determinants and systemic disease and quality of life outcomes, with a special focus on the study of clinical interventional study of the relationship of periodontal diseases and diabetes and especially the impact of periodontal treatment on the control of the diabetic complications.

描述（由申请人提供）：受过指导的面向患者的研究职业发展奖（K23）将为受保护的时间提供75％，以供主要研究人员在设计，进行和分析牙科医学研究方面开发独立的研究专业知识。拟议的职业发展计划基础基于候选人的利益以及牙周病学和系统性疾病和临床调查的先前培训和经验。五年计划旨在导致候选人获得艺术硕士学位，在临床调查领域，波士顿大学医学院，并为她提供在临床研究领域开展独立研究计划的经验。职业发展计划提出了教学工作的初始阶段，以及涉及拟议的五年奖励期内的前瞻性，介入临床研究的监督研究经验。临床调查和监督研究计划的正式培训将为候选人提供她提出的研究项目所需的准备，涉及在波士顿大学医学中心和波士顿卫生中心进行的一系列糖尿病患者的牙周健康干预研究。候选人将受到经验丰富的调查员的指导，他们成功地指导了研究受训者的工作。该K23计划将充分利用积极的研究合作，并为候选人提供广泛的面向患者的研究。反过来，由NIH资助的这些现有面向患者的研究项目以及公司和基金会的赞助商将受益于将候选人参与这些计划的能力。首席研究者将有机会建立牙周健康决定因素和全身性疾病和生活质量的现有研究项目，特别关注临床介入的研究牙周疾病与糖尿病的关系，尤其是牙周治疗对糖尿病并发症控制的影响。