Treatment of Periodontitis and Inflammatory Changes in Diabetes

牙周炎和糖尿病炎症变化的治疗

• 批准号: 8067845
• 负责人: HATICE HASTURK
• 金额: $ 12.95万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8067845
• 关键词: Academic Medical Centers; Affect; Anti-Inflammatory Agents; Anti-inflammatory; Area; Arts; Aspirin; Award; Bacteria; Biochemical; Biopsy Specimen; Blood Glucose; Boston; Caring; Cells; Characteristics; Cholesterol; Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Community Healthcare; Comorbidity; Complications of Diabetes Mellitus; Data; Data Analyses; Dental; Development; Development Plans; Diabetes Mellitus; Dinoprostone; Disease; Effectiveness; Effectiveness of Interventions; Elements; Exhibits; Exposure to; Five-Year Plans; Foundations; Funding; Future; Generations; Gingiva; Gingival Crevicular Fluid; Glycosylated Hemoglobin; Goals; Health; Health Personnel; Healthy People 2010; Hemoglobin concentration result; Infection; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interdisciplinary Study; Interleukin-10; Interleukin-6; Intervention Studies; Knowledge; Lead; Leukotriene B4; Life; Lipids; Lipoxins; Literature; Maintenance Therapy; Master' s Degree; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Metalloproteases; Mouth Diseases; Oral; Oral health; Outcome; Pathogenesis; Patients; Periodontal Diseases; Periodontal Infection; Periodontitis; Phagocytes; Preparation; Principal Investigator; Process; Production; Prospective Studies; Public Health; Quality of life; Reporting; Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Serum; Severities; Structure; Superoxides; Systemic disease; TNF gene; Time; Tissue Sample; Tissues; Training; Training Programs; United States National Institutes of Health; Universities; Work; adiponectin; base; career development; cohort; cytokine; design; diabetic; diabetic patient; experience; glycemic control; health disparity; improved; inflammatory marker; interest; lipid mediator; medical schools; migration; monocyte; neutrophil; patient oriented research; peripheral blood; prevent; programs; prospective; research study; response; skills; therapy development

DESCRIPTION (provided by applicant): The Mentored Patient-Oriented Research Career Development Award (K23) will provide protected time, at 75%, for the principal investigator to develop independent research expertise in the design, conduct, and analysis of patient- oriented research in dental medicine. The proposed career development plan basis on the candidate's interests and previous training and experience in periodontology and systemic diseases and clinical investigations. The five-year plan is designed to lead to the candidate receiving the degree of Master of Arts, in the area of Clinical Investigations, from the Boston University School of Medicine and to provide her with experience of conducting independent research program in the field of clinical research. The career development plan proposes an initial period of didactic work, together with a supervised research experience involving a prospective, interventional clinical research study of diabetes and periodontal infections, in the proposed five-year award period. The formal training in clinical investigation and the supervised research program will provide the candidate with the preparation needed to carry out her proposed research project involving a periodontal health intervention study in a cohort of patients with diabetes being followed at Boston University Medical Center and BostonNet Health Centers. The candidate will be mentored by experienced investigators who have a successful track record of guiding the work of research trainees. This K23 program will take a full advantage of active research collaborations, and provide the candidate with a broad exposure to patient-oriented research. In turn, these existing patient-oriented research projects, funded by the NIH, and corporate and foundation sponsors, will benefit by the ability to involve the candidate in these programs. The principal investigator will have the opportunity to build on existing research projects in the area of periodontal health determinants and systemic disease and quality of life outcomes, with a special focus on the study of clinical interventional study of the relationship of periodontal diseases and diabetes and especially the impact of periodontal treatment on the control of the diabetic complications.

描述（由申请人提供）：指导患者导向研究职业发展奖（K23）将提供75%的保护时间，用于首席研究员在牙科医学中以患者为导向的研究的设计，实施和分析方面发展独立的研究专业知识。建议的职业发展计划基于候选人的兴趣和以前在牙周病和全身性疾病以及临床调查方面的培训和经验。该五年计划旨在使候选人获得波士顿大学医学院临床研究领域的文学硕士学位，并为她提供在临床研究领域开展独立研究项目的经验。职业发展计划提议在拟议的五年奖励期内进行一段初期的教学工作，并进行有监督的研究经验，包括对糖尿病和牙周感染进行前瞻性、介入性临床研究。临床调查方面的正式培训和受监督的研究计划将为候选人提供开展她所提议的研究项目所需的准备，该研究项目涉及在波士顿大学医学中心和BostonNet健康中心对一组糖尿病患者进行牙周健康干预研究。候选人将由经验丰富的研究人员指导，他们在指导研究学员的工作方面有成功的记录。该K23项目将充分利用积极的研究合作，并为候选人提供广泛的面向患者的研究机会。反过来，这些由美国国立卫生研究院、企业和基金会资助的现有的以患者为导向的研究项目，将因候选人参与这些项目的能力而受益。首席研究员将有机会在牙周健康决定因素、全身性疾病和生活质量结果领域现有研究项目的基础上，特别关注牙周疾病和糖尿病关系的临床介入研究，特别是牙周治疗对糖尿病并发症控制的影响。