BIOLOGIC BASIS OF REFRACTORY PERIDONTAL DISEASE

难治性牙周病的生物学基础

• 批准号: 7606220
• 负责人: HATICE HASTURK
• 金额: $ 8.3万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606220
• 关键词: Antibiotic Therapy; Caring; Complex; Computer Retrieval of Information on Scientific Projects Database; Dentists; Diagnosis; Disease; Funding; Goals; Grant; Herpesviridae; Infection; Institution; Integration Host Factors; Operative Surgical Procedures; Pathogenesis; Patient Education; Patients; Periodontal Diseases; Periodontitis; Population; Prevention therapy; Refractory; Refractory Disease; Research; Research Personnel; Resources; Source; Treatment Failure; United States National Institutes of Health; base; cost; microbial host

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While most periodontal patients can be treated successfully by some combination of patient education, scaling, surgery, and antibiotic therapy, some patients contunue to break down which is extremely frustrating and disturbing for both patients and dentists. We define this group as having refractory periodontal disease. We believe that understanding refractory periodontitis is the most significant problem currently facing periodontal research because of the impact that eliminating treatment failure would have on the delivery and cost of periodontal care. The biologic basis for refractory periodontal diseases is poorly understood, but we hypothesize that it is due to infection with specific bacterial species (possibly newly recognized or "unticultivable") or bacterial complexes in a host that may be subtly immuno-compromised. Furthermore, the presence of herpes viruses may contribute to the pathogenesis of the disease. The long-term goals for the level, to diagnose, and to develop effective therapies for prevention and treatment of refractory periodontal disease. Currently about 10 to 15% of periodontitis patients fail to respond well to conventional therapy and are deemed refractory. The goals of this proposal are to examine the hypothesis that refractory disease is distinct from non-refractory periodontal disease population based upon analyses of microbial and host factors.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 虽然大多数牙周患者可以通过患者教育、洁治、手术和抗生素治疗的某种组合来成功治疗，但有些患者继续恶化，这对患者和牙医来说都非常令人沮丧和不安。我们将这一群体定义为患有难治性牙周病。我们认为，了解难治性牙周炎是目前牙周研究面临的最重要的问题，因为消除治疗失败会对牙周护理的实施和成本产生影响。难治性牙周病的生物学基础尚不清楚，但我们假设这是由于宿主体内特定细菌种类（可能是新识别的或“不可培养的”）或细菌复合物的感染而导致的，而宿主可能会轻微地免疫受损。此外，疱疹病毒的存在可能有助于该疾病的发病机制。诊断和开发预防和治疗难治性牙周病的有效疗法的长期目标。目前，约 10% 至 15% 的牙周炎患者对常规治疗反应不佳，被认为是难治性的。该提案的目标是根据微生物和宿主因素的分析，检验难治性牙周病与非难治性牙周病人群不同的假设。