BIOLOGIC BASIS OF REFRACTORY PERIDONTAL DISEASE

难治性牙周病的生物学基础

• 批准号: 7606220
• 负责人: HATICE HASTURK
• 金额: $ 8.3万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606220
• 关键词: Antibiotic Therapy; Caring; Complex; Computer Retrieval of Information on Scientific Projects Database; Dentists; Diagnosis; Disease; Funding; Goals; Grant; Herpesviridae; Infection; Institution; Integration Host Factors; Operative Surgical Procedures; Pathogenesis; Patient Education; Patients; Periodontal Diseases; Periodontitis; Population; Prevention therapy; Refractory; Refractory Disease; Research; Research Personnel; Resources; Source; Treatment Failure; United States National Institutes of Health; base; cost; microbial host

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While most periodontal patients can be treated successfully by some combination of patient education, scaling, surgery, and antibiotic therapy, some patients contunue to break down which is extremely frustrating and disturbing for both patients and dentists. We define this group as having refractory periodontal disease. We believe that understanding refractory periodontitis is the most significant problem currently facing periodontal research because of the impact that eliminating treatment failure would have on the delivery and cost of periodontal care. The biologic basis for refractory periodontal diseases is poorly understood, but we hypothesize that it is due to infection with specific bacterial species (possibly newly recognized or "unticultivable") or bacterial complexes in a host that may be subtly immuno-compromised. Furthermore, the presence of herpes viruses may contribute to the pathogenesis of the disease. The long-term goals for the level, to diagnose, and to develop effective therapies for prevention and treatment of refractory periodontal disease. Currently about 10 to 15% of periodontitis patients fail to respond well to conventional therapy and are deemed refractory. The goals of this proposal are to examine the hypothesis that refractory disease is distinct from non-refractory periodontal disease population based upon analyses of microbial and host factors.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 尽管大多数牙周患者可以通过患者教育，缩放，手术和抗生素疗法的某种结合成功地治疗，但一些患者会碰撞，这对患者和牙医来说都是非常令人沮丧和令人不安的。我们将这一组定义为患有耐火牙周疾病。我们认为，了解难治性牙周炎是目前在牙周研究中面临的最重大问题，因为消除治疗失败会对牙周护理的分娩和成本产生影响。耐火性牙周疾病的生物学基础知之甚少，但我们假设它是由于特定细菌物种（可能是新识别或“不可忽视的”）或细菌复合物的感染引起的，或者可能会受到微弱免疫证明。此外，疱疹病毒的存在可能有助于疾病的发病机理。该水平的长期目标，诊断和开发有效的预防和治疗难治性牙周疾病的疗法。目前，大约10％至15％的牙周炎患者对常规疗法的反应良好，被认为是难治性的。该提案的目标是研究以下假设：根据对微生物和宿主因素的分析，难治性疾病与非冷冻牙周疾病人群不同。