Administrative/Budgeting, Biostatistics and Data Integration

行政/预算编制、生物统计和数据集成核心将提供集中赠款 管理、项目1-3的所有统计支持和分析，以及使用 纳皮斯数据库。核心D还将用于合并调查人员、他们的实验结果和 他们的想法、对研究工作的评价和指导总结努力保持了高度的 综合计划成果。行政/预算编制和生物统计核心的具体目标和 数据集成的核心是：1)为调查人员提供基本的行政和服务(包括 管理项目用品、归档、编写备忘录、会议纪要和通信 涵盖所有业务，包括出版物和摘要)。这一核心将为调查人员提供明确的 科学和行政沟通渠道，以促进团队成员之间的合作，帮助 确定资源的优先顺序，并促进解决影响团队成员的任何问题。2)提供 对所有项目进行统计分析，[(A)与项目调查员协作制定 假设和研究设计；(B)进行和指导数据的统计分析，包括 描述性汇总统计和复杂的推断程序，包括数组分析；(C)努力 生物统计小组应包括及时审查、质量保证、传播收集的结果 来自所有项目的调查]。3)组织项目指导委员会月度会议。这 指导委员会应由项目和核心绩效指标组成。4)为所有人组织计划项目会议 项目成员及其实验室成员。5)组织内部审查委员会会议 专家小组应评估计划的有效性和实验进展、研究 指导、技术方法、统计评价和行政效力。6)组织一场 外部审查委员会年度会议。外部审查委员会的成员应审查所有 实验结果和结果，有助于确定调查的优先顺序，审查合作的协调， 并对研究中出现的概念进行评估。7)提供全面的财务审查、会计和实际 时间预算分析。这包括报告、口头交流、回顾和前瞻性 对支出的预测。8)基于天然产物信息的实验数据集成 系统(NAPIS)实时关系数据库，广泛用于支持天然药物 发现号。

The Administrative/Budgeting and Biostatistics and Data Integration Core will provide centralized grant administration, and all statistical support and analyses for Projects 1-3, and data management using the NAPIS database. Core D will also serve to amalgamate the investigators, their experimental findings and their ideas, evaluation of research efforts and direct the summary efforts toward maintaining a highly integrated Program outcome. The Specific Aims of the Administrative/Budgeting and Biostatistics Core and Data Integration Core are to: 1) Provide basic administrative and services to the investigators (including the management of project supplies, filing, development of memos, meeting minutes and communications covering all operations, including publications and abstracts). This core will provide investigators with clear lines of scientific and administrative communication to promote collaboration among team members, aid in the prioritization of resources, and facilitate resolution of any problems that affect team members. 2) Provide statistical analyses for all projects, [(a) To collaborate with project investigators in the formulation of hypotheses and study design; (b) To conduct and direct the statistical analysis of data including both descriptive summary statistics and sophisticated inferential procedures, including array analyses; (c) Efforts by the Biostatistics group shall include timely review, quality assurance, dissemination of the results gleaned from investigations in all projects]. 3) Organize monthly meetings of the Program Steering Committee. This Steering committee shall consist of the Project and Core Pis. 4) Organize Program Project meetings for all members of the project and their laboratory members. 5) Organize Internal Review Committee meetings where a panel of experts shall assess the Program effectiveness and experimental progress, research directions, technical approaches, statistical evaluation, and administrative effectiveness. 6) Organize an annual External Review Committee meeting. The members of External Review Committee shall review all experimental findings and outcomes, help prioritize investigations, review the coordination of collaborations, and evaluate concepts that emerge from the studies. 7) Provide overall fiscal review, accounting, and real time budgets analyses. This includes reports, verbal communications, reviews and forward-looking projections on expenditures. 8) Experimental data integration through the Natural Products Information System (NAPIS) real-time, relational database, which is widely used to support natural product drug discovery.