Multi-Spectral Targeted Imaging for Early Detection of Cancer in Barrett's Esopha

多光谱靶向成像用于巴雷特食管癌症的早期检测

基本信息

  • 批准号:
    8209767
  • 负责人:
  • 金额:
    $ 114.45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-21 至 2016-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The broad, long-term objective of this project is to develop a multi-institutional, multi-disciplinary translational Research Center to accelerate the clinical use of targeted imaging methodologies for the early detection and prevention of esophageal adenocarcinoma through the Barrett's Esophagus Translational Research Network (BETRNet). 3 inter-related Primary Research Projects and Shared Research Resources (Cores) will be established to develop advanced endoscopic imaging as an enabling technology for management of patients with Barrett's esophagus by visualizing molecular targets from amplified and overexpressed genes. In Project 1, genomic data will be analyzed to identify molecular targets based on properties of gene amplification and/or overexpression. These targets will be used to select highly specific peptides in Project 2 that will be fluorescent-labeled for detection on imaging. A multi-spectral scanning fiber endoscope will be developed in Project 3 to perform real time visualization of a panel of peptides in 3 fluorescence channels. The unique instrument design can pass through the working channel of a standard medical endoscope to allow for concurrent white light imaging. Future versions of this instrument may have 12 or more channels. Image processing algorithms will developed to "red-flag" diseased regions on a panoramic view of the distal esophagus. This integrated imaging strategy aims to assist the physician in guiding tissue biopsy of high grade dysplasia and early adenocarcinoma that can not been seen otherwise. Phase 1 studies will be performed to prepare for a future multi-center clinical validation study. Future applications will allow for real time spatial visualization and monitoring of other targets, including those associated with stem cells or with biomarkers of cancer risk. Moreover, imaging of molecular targets can be performed in patients with Barrett's esophagus over time to better understand the molecular mechanisms of this disease. The 3 Cores will support the Primary Research Projects, Pilot Projects, and Cross-BETRNet Projects. The Administrative Core will provide support for grants and regulatory management, including budgets, financial reporting, progress reports, human subjects protocols, investigation of new drug (IND) applications, and Steering Committee representation. The Bioinformatics Core will provide support the Primary Projects for statistical evaluation of genomic, imaging, and clinical data and the BETRNet Network for data sharing and archiving of tissue specimens. The Validation & Pathology Core will provide support for validation of peptide binding activity to amplified and overexpressed gene targets in high-grade dysplasia and early adenocarcinoma.
描述(由申请人提供):该项目的广泛、长期目标是建立一个多机构、多学科的转化研究中心,通过巴雷特食管转化研究网络(BETRNet)加速靶向成像方法在食管腺癌早期检测和预防中的临床应用。将建立3个相互关联的主要研究项目和共享研究资源(核心),以开发先进的内窥镜成像技术,通过可视化扩增和过表达基因的分子靶点来管理巴雷特食管患者。在项目1中,将分析基因组数据,以根据基因扩增和/或过表达的特性识别分子靶标。这些目标将用于在项目2中选择高度特异性的肽,这些肽将被荧光标记用于成像检测。项目3将开发一种多光谱扫描光纤内窥镜,以在3个荧光通道中对一组肽进行真实的实时可视化。独特的仪器设计可以穿过标准医用内窥镜的工作通道,以允许同时进行白色光成像。该仪器的未来版本可能有12个或更多通道。将开发图像处理算法,以在远端食管的全景图上对患病区域进行“红色标记”。这种综合成像策略的目的是帮助医生指导组织活检的高度异型增生和早期腺癌,否则不能看到。将进行I期研究,为未来的多中心临床验证研究做准备。未来的应用将允许真实的时间空间可视化和监测其他目标,包括与干细胞或癌症风险生物标志物相关的目标。此外,随着时间的推移,可以在巴雷特食管患者中进行分子靶点成像,以更好地了解这种疾病的分子机制。这三个核心将支持主要研究项目、试点项目和跨BETRNet项目。行政核心将为赠款和监管管理提供支持,包括预算、财务报告、进度报告、人类受试者方案、新药(IND)申请调查和指导委员会代表。生物信息学核心将为基因组、成像和临床数据的统计评估的主要项目以及用于组织标本数据共享和存档的BETRNet网络提供支持。Validation & Pathology Core将为高度异型增生和早期腺癌中扩增和过表达基因靶点的肽结合活性验证提供支持。

项目成果

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专利数量(0)

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DAVID George BEER其他文献

DAVID George BEER的其他文献

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{{ truncateString('DAVID George BEER', 18)}}的其他基金

RNF128 Regulation of TP53 in Barrett's Progression
RNF128 对 Barrett 进展中 TP53 的调节
  • 批准号:
    10219176
  • 财政年份:
    2017
  • 资助金额:
    $ 114.45万
  • 项目类别:
Biomedical Computing and Informatics Strategies for Precision Medicine
精准医学的生物医学计算和信息学策略
  • 批准号:
    9366045
  • 财政年份:
    2017
  • 资助金额:
    $ 114.45万
  • 项目类别:
RNF128 Regulation of TP53 in Barrett's Progression
RNF128 对 Barrett 进展中 TP53 的调节
  • 批准号:
    9976469
  • 财政年份:
    2017
  • 资助金额:
    $ 114.45万
  • 项目类别:
Multi-Spectral Targeted Imaging for Early Detection of Cancer in Barrett's Esopha
多光谱靶向成像用于巴雷特食管癌症的早期检测
  • 批准号:
    8724430
  • 财政年份:
    2011
  • 资助金额:
    $ 114.45万
  • 项目类别:
Early Targets in Progression of Barrett's Esophagus to Esophageal Adenocarcinoma
巴雷特食管进展为食管腺癌的早期目标
  • 批准号:
    9277831
  • 财政年份:
    2011
  • 资助金额:
    $ 114.45万
  • 项目类别:
Identification and Characterization of Gene Fusions in Lung Adenocarcinoma
肺腺癌基因融合的鉴定和表征
  • 批准号:
    8018735
  • 财政年份:
    2011
  • 资助金额:
    $ 114.45万
  • 项目类别:
Identification and Characterization of Gene Fusions in Lung Adenocarcinoma
肺腺癌基因融合的鉴定和表征
  • 批准号:
    8249361
  • 财政年份:
    2011
  • 资助金额:
    $ 114.45万
  • 项目类别:
Multi-Spectral Targeted Imaging for Early Detection of Cancer in Barrett's Esopha
多光谱靶向成像用于巴雷特食管癌症的早期检测
  • 批准号:
    8919278
  • 财政年份:
    2011
  • 资助金额:
    $ 114.45万
  • 项目类别:
Project 1: Identification and Validation of Panel of Early Cell Surface Gene Targets
项目 1:早期细胞表面基因靶标组的鉴定和验证
  • 批准号:
    10155438
  • 财政年份:
    2011
  • 资助金额:
    $ 114.45万
  • 项目类别:
Identification and Characterization of Gene Fusions in Lung Adenocarcinoma
肺腺癌基因融合的鉴定和表征
  • 批准号:
    8445146
  • 财政年份:
    2011
  • 资助金额:
    $ 114.45万
  • 项目类别:

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