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Identification of Cell Surface Targets Based on Gene Amplification/Overexpression

Identification of Cell Surface Targets Based on Gene Amplification/Overexpression
基于基因扩增/过表达的细胞表面靶点鉴定
批准号:
8555330
负责人:
DAVID George BEER
金额:
$41.79万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-21 至 2016-08-31

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中文摘要
翻译
一个由15个候选靶点组成的小组将根据这两种高频放大来确定
英文摘要
A panel of 15 candidate targets will be identifed based on both high-frequency amplified chromosomal regions and mRNA overexpression from a SNP array database of specimens of neoplastic Barrett's esophageal mucosa with support from Core B. Validafion of selected gene candidates will be performed on an independent set of 50 cases of Barrett's metaplasia, low-grade, high-grade dysplasia and adenocarcinoma using quantitative RT-PCR and at the protein level using fissue microarrays and immunohistochemistry with support from Core C. This panel will be reduced to the 5 best candidate amplified and/or overexpressed cell surface genes will be transfected into immortalized Barrett's metaplasia cells for in vitro selection of imaging peptides in Project 2 for imaging with a mulfi-spectral scanning flber endoscope developed in Project 3.
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会议论文
RNF128 Regulation of TP53 in Barrett's Progression
Biomedical Computing and Informatics Strategies for Precision Medicine
  • 批准号:
    9366045
  • 项目类别:
  • 资助金额:
    $35.92万
  • 财政年份:
    2017
  • 负责人:
    DAVID George BEER
  • 依托单位:
RNF128 Regulation of TP53 in Barrett's Progression
Multi-Spectral Targeted Imaging for Early Detection of Cancer in Barrett's Esopha
国内基金
海外基金
大肠癌发生机制的adenoma-adenocarcinoma pathway同serrated pathway的关系的研究
  • 批准号:
    30840003
  • 项目类别:
    专项基金项目
  • 资助金额:
    12.0万元
  • 批准年份:
    2008
  • 负责人:
    焦宇飞
  • 依托单位: