ADMINISTRATIVE CORE

推动这一P50应用的问题是“FDA强制的新标准是否需要非常低的 尼古丁水平（例如，<0.20毫克），减少香烟使用，改善公众健康？“地址 这个问题需要协调努力，将不同的学科方法与 开展高质量研究并将研究成果转化为循证政策的共同目标 建议.行政核心（核心A;核心领导人：Eric Donny和Dorothy Hatsukami） 将设在匹兹堡大学，并将提供以下功能：1）提供管理 和监督P50，并促进研究者之间的沟通和协作; 2） 开发和维护综合和质量方法，措施，数据收集和数据管理; 3） 提供论坛，讨论这些研究如何有助于尼古丁和其他 烟草的成瘾成分; 4）将我们的研究结果传播给研究人员，监管机构和 5）资助解决烟草产品评估中其他研究空白的试点研究。 在该核心下成立的委员会将协助履行这些职能，包括指导委员会， 概念框架和翻译科学委员会，传播和政策委员会， 试点项目委员会。此外，一个内部和外部咨询委员会将每年提供两次， 每年分别就中心的总体方向、需要解决的领域和 正在取得进展。总而言之，该核心将确保跨部门的沟通和协作。 研究人员，高质量的科学和项目成果的翻译维护，以最大限度地 对政策和公共卫生的影响 相关性（参见说明）： 行政核心将有助于促进研究者之间的互动， 研究结果纳入一个共同的概念框架，并向其他科学家传播研究结果， 制造商、监管机构和广大公众。这项工作对于翻译拟议的 研究最终将影响公共卫生的具体未来方向和政策建议。

The question driving this P50 application is "Would an FDA-mandated new standard requiring very low nicotine levels (e.g., <0.20 mg) in cigarettes reduce cigarette use and improve public health?" Addressing this question requires a coordinated effort in which different disciplinary approaches are integrated with the common goal of conducting high quality research and translating this research into evidence-based policy recommendations. The Administrative Core (Core A; Core Leaders: Eric Donny and Dorothy Hatsukami) will be housed at the University of Pittsburgh and will serve the following functions: 1) to provide management and oversight of the P50 and facilitate communication and collaboration among the investigators; 2) to develop and maintain integrated and quality methods, measures, data collection, and data management; 3) to provide forums for discussing how these studies contribute to the potential regulation of nicotine and other addictive constituents of tobacco; 4) to disseminate our findings to researchers, regulatory agencies and the public; and, 5) to fund pilot studies that address other research gaps in tobacco product evaluation. Committees formed under this Core will assist in performing these functions including a Steering Committee, a Conceptual Framework and Translational Science Committee, a Dissemination and Policy Committee, and a pilot Project Committee. Furthermore, an Internal and External Advisory Board will provide biannual and annual input respectively on the overall direction of the center, areas that need to be addressed, and progress being made. In summary, this Core will ensure communication and collaboration across investigators, the maintenance of high quality science and translation of the project results to have maximal impact on policy and public health RELEVANCE (See instructions): The Administrative Core will serve to facilitate the interaction between Investigators, the integration of findings into a common conceptual framework, and the dissemination of results to other scientists, policy- makers, regulatory agencies, and the public at large. This work is critical for translating the proposed research into specific future directions and policy recommendations that will ultimately impact public health.