Evaluating New Nicotine Standards for Cigarettes

评估卷烟新尼古丁标准

• 批准号: 10578938
• 负责人: ERIC Christian DONNY
• 金额: $ 32.21万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10578938
• 关键词: Adult; Age; Area; Attitude; Behavior; Behavioral; Belief; Biological Markers; Cigarette; Communities; Complex; Country; Data; Decision Making; Dependence; Enrollment; Ensure; Ethnic group; Exposure to; Funding; Future; Generations; Goals; Government; Health; Health Benefit; Health Promotion; Health behavior; Heavy Drinking; Indigenous; Individual; Interview; Laws; Leadership; Learning; Measures; Mental Depression; Mental Health; Methods; New Zealand; Nicotine; Pacific Islander; Participant; Perception; Personal Satisfaction; Persons; Policies; Population; Public Health; Qualitative Research; Randomized Clinical Trials; Recording of previous events; Regulation; Reporting; Research; Research Personnel; Risk; Risk Factors; Sales; Sampling; Services; Smoke; Smoker; Smoking; Subgroup; Surveys; Time; Tobacco; Tobacco Dependence; Tobacco Industry; Tobacco smoke; Tobacco use; United States Food and Drug Administration; Universities; Woman; Work; Youth; base; biobank; cigarette smoking; cohort; design; environmental tobacco smoke exposure; health inequalities; low nicotine content cigarette; marijuana use; recruit; response; self-reported anxiety; smoking cessation; smoking during pregnancy; smoking prevalence; socioeconomics; tobacco products; tobacco user; young adult

PROJECT SUMMARY On December 9, 2021, the New Zealand Government launched the Smokefree Aotearoa 2025 Action Plan, outlining a strategy to reduce smoking prevalence to less than 5% for all populations in New Zealand by 2025. The plan includes a commitment to only having low-level nicotine smoked tobacco products for sale. A low nicotine product standard has also been proposed as a cornerstone of the United States Food and Drug Administration’s Comprehensive Plan for Tobacco and Nicotine Regulation. Previous research has demonstrated that when tobacco users switch to very low nicotine content cigarettes there is a reduction in cigarettes per day, dependence and biomarkers of smoke exposure, plus an increase in quit attempts and smoking cessation; and relatively few unintended consequences. However, to date, no country has implemented a low nicotine product standard; therefore, the real world impact of regulation has not been evaluated. We propose to conduct an exploratory sequential mixed methods study in New Zealand adults who smoke tobacco cigarettes to assess product perceptions, concerns for individual health and well-being, need for support services, and behavioral intentions in response to a pending mandated reduction of nicotine in all smoked tobacco products. The survey will also include items from a wide range of domains including tobacco use behaviors; tobacco dependence; attitudes, beliefs, and norms; other health behaviors; significant health conditions and associated risk factors; mental health indicators; and smoking cessation history. Biosamples will be banked in a biorepository located at the University of Auckland for future analysis of changes in objective measures of exposure to tobacco smoke. The proposed research focuses on populations with high smoking prevalence (oversampling important ethnic groups: Maori, Pacific Islanders), including: 1) Individuals with self-reported anxiety, depression and other mental health concerns; 2) Young adult women (age 18-24 years) living in socioeconomically deprived areas of New Zealand who are at a much greater risk of smoking during pregnancy; and 3) Individuals who report heavy alcohol and/or cannabis use.

项目摘要 2021年12月9日，新西兰政府推出《无烟奥特亚罗瓦2025行动计划》， 概述了到2025年将新西兰所有人口的吸烟率降低到5%以下的战略。 该计划包括一项承诺，即只有低尼古丁含量的吸烟烟草产品用于销售。低 尼古丁产品标准也被提议作为美国食品和药物管理局 政府的烟草和尼古丁监管综合计划。先前的研究 研究表明，当烟草使用者转向尼古丁含量非常低的香烟时， 吸烟，依赖性和吸烟暴露的生物标志物，加上戒烟尝试的增加， 戒烟;和相对较少的意外后果。然而，迄今为止，没有一个国家 实施了低尼古丁产品标准;因此，监管的真实的世界影响尚未得到 评估。我们建议在新西兰成年人中进行一项探索性序贯混合方法研究， 吸烟烟草香烟，以评估产品的看法，对个人健康和福祉的关注， 支持服务和行为意图，以应对即将强制减少尼古丁在所有 烟草制品。调查还将包括烟草等广泛领域的物品 使用行为;烟草依赖;态度、信念和规范;其他健康行为;显著健康 条件和相关的风险因素;心理健康指标;和戒烟史。生物样本 将储存在位于奥克兰大学的生物储存库中，用于未来分析 客观测量暴露于烟草烟雾。这项研究的重点是高血压人群。 吸烟率（对重要族裔群体进行过抽样：毛利人、太平洋岛民），包括：1）个人 有自我报告的焦虑、抑郁和其他心理健康问题; 2）年轻成年女性（18-24岁 生活在新西兰社会经济贫困地区，吸烟风险更大的人 怀孕期间;和3）报告重度酒精和/或大麻使用的个人。

项目成果

Randomized Trial of Reduced-Nicotine Standards for Cigarettes.

• DOI: 10.1056/nejmsa1502403
• 发表时间: 2015-10
• 期刊: The New England journal of medicine
• 作者: Donny EC;Denlinger RL;Tidey JW;Koopmeiners JS;Benowitz NL;Vandrey RG;al'Absi M;Carmella SG;Cinciripini PM;Dermody SS;Drobes DJ;Hecht SS;Jensen J;Lane T;Le CT;McClernon FJ;Montoya ID;Murphy SE;Robinson JD;Stitzer ML;Strasser AA;Tindle H;Hatsukami DK
• 通讯作者: Hatsukami DK

Low-dose nicotine self-administration is reduced in adult male rats naïve to high doses of nicotine: implications for nicotine product standards.

• DOI: 10.1037/a0037396
• 发表时间: 2014-10
• 期刊: Experimental and clinical psychopharmacology
• 影响因子: 2.3
• 作者: Smith TT;Schassburger RL;Buffalari DM;Sved AF;Donny EC
• 通讯作者: Donny EC

Tobacco harm reduction: Past history, current controversies and a proposed approach for the future.

• DOI: 10.1016/j.ypmed.2020.106099
• 发表时间: 2020-11
• 期刊: Preventive medicine
• 影响因子: 5.1
• 作者: Hatsukami DK;Carroll DM
• 通讯作者: Carroll DM

Nicotine and Anatabine Exposure from Very Low Nicotine Content Cigarettes.

• DOI: 10.18001/trs.2.2.9
• 发表时间: 2016-04
• 期刊: Tobacco regulatory science
• 作者: Denlinger RL;Smith TT;Murphy SE;Koopmeiners JS;Benowitz NL;Hatsukami DK;Pacek LR;Colino C;Cwalina SN;Donny EC
• 通讯作者: Donny EC

Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence.

• DOI: 10.1037/pha0000179
• 发表时间: 2018-06
• 期刊: Experimental and clinical psychopharmacology
• 影响因子: 2.3
• 作者: Dermody SS;McClernon FJ;Benowitz N;Luo X;Tidey JW;Smith TT;Vandrey R;Hatsukami D;Donny EC
• 通讯作者: Donny EC