Evaluating New Nicotine Standards for Cigarettes

项目摘要 2021年12月9日，新西兰政府推出《无烟奥特亚罗瓦2025行动计划》， 概述了到2025年将新西兰所有人口的吸烟率降低到5%以下的战略。 该计划包括一项承诺，即只有低尼古丁含量的吸烟烟草产品用于销售。低 尼古丁产品标准也被提议作为美国食品和药物管理局 政府的烟草和尼古丁监管综合计划。先前的研究 研究表明，当烟草使用者转向尼古丁含量非常低的香烟时， 吸烟，依赖性和吸烟暴露的生物标志物，加上戒烟尝试的增加， 戒烟;和相对较少的意外后果。然而，迄今为止， 实施了低尼古丁产品标准;因此，监管的真实的世界影响尚未得到 评估。我们建议在新西兰成年人中进行一项探索性序贯混合方法研究， 吸烟烟草香烟，以评估产品的看法，对个人健康和福祉的关注， 支持服务和行为意图，以应对即将强制减少尼古丁在所有 烟草制品。调查还将包括烟草等广泛领域的物品 使用行为;烟草依赖;态度、信念和规范;其他健康行为;显著健康 条件和相关的风险因素;心理健康指标;和戒烟史。生物样本 将储存在位于奥克兰大学的生物储存库中，用于未来分析 客观测量暴露于烟草烟雾。这项研究的重点是高血压人群。 吸烟率（对重要族裔群体进行过抽样：毛利人、太平洋岛民），包括：1）个人 有自我报告的焦虑、抑郁和其他心理健康问题; 2）年轻成年女性（18-24岁 生活在新西兰社会经济贫困地区，吸烟风险更大的人 怀孕期间;和3）报告重度酒精和/或大麻使用的个人。

PROJECT SUMMARY On December 9, 2021, the New Zealand Government launched the Smokefree Aotearoa 2025 Action Plan, outlining a strategy to reduce smoking prevalence to less than 5% for all populations in New Zealand by 2025. The plan includes a commitment to only having low-level nicotine smoked tobacco products for sale. A low nicotine product standard has also been proposed as a cornerstone of the United States Food and Drug Administration’s Comprehensive Plan for Tobacco and Nicotine Regulation. Previous research has demonstrated that when tobacco users switch to very low nicotine content cigarettes there is a reduction in cigarettes per day, dependence and biomarkers of smoke exposure, plus an increase in quit attempts and smoking cessation; and relatively few unintended consequences. However, to date, no country has implemented a low nicotine product standard; therefore, the real world impact of regulation has not been evaluated. We propose to conduct an exploratory sequential mixed methods study in New Zealand adults who smoke tobacco cigarettes to assess product perceptions, concerns for individual health and well-being, need for support services, and behavioral intentions in response to a pending mandated reduction of nicotine in all smoked tobacco products. The survey will also include items from a wide range of domains including tobacco use behaviors; tobacco dependence; attitudes, beliefs, and norms; other health behaviors; significant health conditions and associated risk factors; mental health indicators; and smoking cessation history. Biosamples will be banked in a biorepository located at the University of Auckland for future analysis of changes in objective measures of exposure to tobacco smoke. The proposed research focuses on populations with high smoking prevalence (oversampling important ethnic groups: Maori, Pacific Islanders), including: 1) Individuals with self-reported anxiety, depression and other mental health concerns; 2) Young adult women (age 18-24 years) living in socioeconomically deprived areas of New Zealand who are at a much greater risk of smoking during pregnancy; and 3) Individuals who report heavy alcohol and/or cannabis use.