Developmental Research Core

发展研究核心

• 批准号: 8073250
• 负责人: LEWIS A CHODOSH
• 金额: $ 11.87万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-24 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8073250
• 关键词: Adverse effects; Area; Breast; Cancer Biology; Cancer Center; Cancer Survivor; Cancer Survivorship; Clinical; Clinical Oncology; Communities; Consultations; Development; Diabetes Mellitus; Exercise; Funding; Goals; Institutes; Institution; Interdisciplinary Study; Investigation; Leadership; Metabolism; Mission; Obesity; Outcome; Pilot Projects; Population; Recurrence; Research; Research Activity; Research Project Grants; Research Proposals; Research Support; Resources; Risk; Scientist; Survivors; T-Cell Receptor-Rearrangement Excision DNA Circles; Testing; Translating; Translational Research; Weight maintenance regimen; cancer recurrence; cancer type; community setting; energy balance; improved; innovation; outreach; programs; success; survivorship

The Developmental Core ofthe Penn TREC Survivor Center will facilitate research on the effects of energy balance on cancer recurrence by combining the unique strengths of our institution in obesity and cancer biology to focus on cancer survivorship. This Core will be co-led by Dr. Lewis Chodosh, Chair of the Department of Cancer Biology and Associate Director of the Abramson Cancer Center, and Dr. Rexford Ahima, Associate Director ofthe Penn Institute for Diabetes, Obesity and Metabolism. In consultation with Penn TREC Center leadership and advisors, the Development Core will be responsible for soliciting, prioritizing and selecting developmental pilot projects to explore new ideas and capitalize on emerging opportunities that have the potential to contribute to existing TREC Center initiatives. The Developmental Core will also participate in formulating Cross-TREC pilot projects involving multiple TREC centers. An additional focus of the Developmental Core will be to promote activities with the potential to synergistically impact on outcomes ofthe TREC Program, including outreach efforts to bring in expertise from outside the Penn TREC to enhance its research activities, and outreach efforts to non-TREC entities to extend the reach of the TREC initiative into new communities of scientists. The Developmental Core will enable the Penn TREC Survivor Center to expand upon the conceptual platform formed by its three primary research projects, thereby extending the reach of its investigations to the effects of exercise and obesity on recurrence of other types of cancer beyond breast, as well as other persistent adverse treatment effects across the translational research continuum. The Specific Aims ofthe Core are: 1) To implement a pilot project program that promotes innovative, interdisciplinary research projects in exercise, obesity and cancer survivorship research; 2) To provide ongoing support for within Center and Cross-TREC pilot projects funded by the Penn TREC Survivor Center; 3. To disseminate the results ofthe developmental research program to the TREC research community and the clinical oncology community; and 4) To evaluate the success of the developmental research program.

Penn TREC幸存者中心的发展核心将通过结合我们机构在肥胖和癌症生物学方面的独特优势来促进能量平衡对癌症复发影响的研究，重点关注癌症生存。该核心将由癌症生物学系主任、艾布拉姆森癌症中心副主任刘易斯·乔多什博士和宾夕法尼亚大学糖尿病、肥胖和代谢研究所副主任雷克斯福德·阿希玛博士共同领导。在与宾州TREC中心领导和顾问协商后，发展核心将负责征求， 优先考虑和选择发展试点项目，以探索新的想法，并利用有可能促进现有TREC中心举措的新机会。发展核心还将参与制定涉及多个TREC中心的跨TREC试点项目。发展核心的另一个重点是促进有可能对TREC计划的成果产生协同影响的活动，包括从外部引进专业知识的外联工作。 宾夕法尼亚大学TREC加强其研究活动，并努力向非TREC实体推广，以将TREC倡议的范围扩大到新的科学家社区。发展核心将使宾州TREC幸存者中心能够扩展其三个主要研究项目形成的概念平台，从而将其研究范围扩展到运动和肥胖对乳腺癌以外其他类型癌症复发的影响，以及其他持续的不良治疗影响。核心的具体目标是：1）实施一个试点项目计划，促进运动，肥胖和癌症生存研究的创新，跨学科的研究项目; 2）提供由宾夕法尼亚州TREC幸存者中心资助的中心内和跨TREC试点项目的持续支持; 3。向TREC研究团体和临床肿瘤学团体传播发展研究计划的结果; 4）评估发展研究计划的成功。