Training in Basic and Clinical Pharmacology in Pregnancy

描述（由申请人提供）：匹兹堡大学培训资助“产科胎儿药理学基础和转化培训”旨在为受训者提供必要的课堂教育，以及必要的研究工具和临床暴露，以弥合围产期药理学有意义和科学合理研究的长期障碍。将招募致力于研究事业并对孕妇及其胎儿研究特别感兴趣的临床和非临床研究科学家。通过有针对性的课程学习、孕妇临床接触和研究培训相结合，学员将获得开展与怀孕有关的研究所需的基本工具。这项培训将与研究导师正在进行的产科药理学研究联系起来，并将导致由学员发起的旨在发展一个研究重点领域的研究。我们建议的具体目标是：1)将匹兹堡大学在基础科学、流行病学、药理学、妇女健康临床研究和教育方面的广泛资源整合到一个独特的产科-胎儿药理学培训项目中。2)招募积极主动，以研究为导向，学术上成功的个人进行产科胎儿药理学培训。3)培养具有独立从事母胎药理学和治疗学基础、转化和临床研究能力的人才。在匹兹堡大学，一个成功的产科胎儿药理学项目的许多组成部分已经存在。这两位研究者在围产期药理学方面的合作研究始于26年前，并且在我们被选为产科胎儿药理学研究单位（OPRU）网络的四个站点之一时仍然很活跃。匹兹堡大学以妊娠为重点的基础、临床和转化研究基础广泛、涉及面广、资金充足。对博士后的培训也同样广泛、完善、非常成功。在母胎医学、围产期生物学、药理学、遗传学、生殖传染病方面已经有了奖学金。当前提案的重点是将匹兹堡大学广泛的资源统一在一个单一的培训项目下，强调多学科方法来培训个人的产科药理学。我们将招收和培养3名临床和5名非临床博士后，通过有针对性的药理学课程和临床研究方法，临床实习和实验室工作，与经验丰富的产科药理学临床，基础和转化研究人员相结合。

DESCRIPTION (provided by applicant): The University of Pittsburgh training grant "Basic and Translational Training in Obstetric- Fetal Pharmacology" aims to provide trainees essential classroom education as well as the research tools and clinical exposures necessary to bridge the longstanding impediments to meaningful and scientifically sound research in perinatal pharmacology. Both clinical and non-clinical research scientists who are committed to a research career and have a particular interest in the study of pregnant women and their fetuses will be recruited. Through a combination of targeted coursework, clinical exposure to pregnant women and research training, trainees will gain the fundamental tools required to carry out research related to pregnancy. This training will be linked to ongoing research in obstetrical pharmacology by research mentors and will lead to trainee-initiated research aimed at developing an area of research focus. The specific aims of our proposal are: 1) To consolidate the extensive resources at the University of Pittsburgh in basic sciences, epidemiology, pharmacology, women's health clinical research and education into a distinct training program in Obstetrical - Fetal pharmacology. 2) To recruit highly motivated, research-oriented, academically successful individuals for training in Obstetric- Fetal pharmacology. 3) To develop these recruits into individuals with sufficient skills to perform independent basic, translational and clinical research in maternal and fetal pharmacology and therapeutics. Many of the components for a successful program in Obstetrical-Fetal pharmacology already exist at the University of Pittsburgh. Collaborative research in perinatal pharmacology by the two investigators began over 26 years ago and is still robust culminating in our selection as one of four sites in the Obstetrical-Fetal Pharmacology Research Units (OPRU) Network. Basic, clinical and translational research focused on pregnancy at the University of Pittsburgh is broad based, extensive and well funded. Training of post-doctoral fellows is likewise extensive, well established, and highly successful. Fellowships in Maternal- Fetal Medicine, perinatal biology, pharmacology, genetics, reproductive infectious diseases already exist. The focus of the current proposal is to unify the extensive resources at the University of Pittsburgh under a single training program that emphasizes a multidisciplinary approach to training individuals in obstetric pharmacology. We will recruit and train 3 clinical and 5 non-clinical post-doctoral candidates through a combination of targeted coursework in pharmacology and clinical research methodologies, clinical practicums and laboratory work with experienced clinical, basic and translational researchers in obstetrical pharmacology. PUBLIC HEALTH RELEVANCE: The most vulnerable population in our society, pregnant women (and their fetuses) receive limited scientific information or guidance about medications they are prescribed. The paucity of scientific investigation in pregnancy-related pharmacology is in large part due to a lack of interest by the pharmaceutical industry and a dearth of investigators at academic institutions. Training programs that unify disparate interest and training in obstetrics and pharmacology are sorely needed to address this critical deficiency.