Training in Basic and Clinical Pharmacology in Pregnancy

描述（由申请人提供）：匹兹堡大学培训补助金“产科-胎儿药理学基础和转化培训”旨在为学员提供必要的课堂教育以及必要的研究工具和临床暴露，以弥合长期存在的障碍，从而在围产期药理学中进行有意义和科学合理的研究。将招募致力于研究事业并对孕妇及其胎儿研究特别感兴趣的临床和非临床研究科学家。通过有针对性的课程，孕妇的临床接触和研究培训相结合，学员将获得进行与怀孕有关的研究所需的基本工具。这项培训将与研究导师正在进行的产科药理学研究相联系，并将导致受训者发起的研究，旨在发展一个研究重点领域。我们建议的具体目标是：1）将匹兹堡大学在基础科学、流行病学、药理学、妇女健康临床研究和教育方面的广泛资源整合成一个独特的产科-胎儿药理学培训计划。2)招募积极性高，研究导向，学术成功的个人进行产科-胎儿药理学培训。3)将这些新兵培养成具有足够技能的个人，以进行独立的基础，转化和临床研究，在孕产妇和胎儿药理学和治疗学。匹兹堡大学已经有许多成功的产科-胎儿药理学项目的组成部分。这两位研究者在围产期药理学方面的合作研究始于26年前，至今仍然很强大，最终我们被选为产科-胎儿药理学研究单位（OPRU）网络的四个站点之一。匹兹堡大学的基础，临床和转化研究侧重于怀孕，基础广泛，广泛，资金充足。博士后研究员的培训同样广泛，完善，非常成功。已经有母婴医学、围产期生物学、药理学、遗传学、生殖传染病方面的研究金。目前提案的重点是将匹兹堡大学的广泛资源统一在一个单一的培训计划下，该计划强调采用多学科方法来培训产科药理学人员。我们将招募和培养3名临床和5名非临床博士后候选人，通过药理学和临床研究方法，临床实习和实验室工作的有针对性的课程相结合，与经验丰富的临床，基础和产科药理学的转化研究人员。 公共卫生相关性：孕妇（及其胎儿）是我们社会中最脆弱的人群，他们获得的关于处方药物的科学信息或指导有限。在与妊娠有关的药理学方面缺乏科学调查，这在很大程度上是由于制药业缺乏兴趣，学术机构缺乏调查人员。培训计划，统一不同的兴趣和培训，产科和药理学是迫切需要解决这一关键的不足。

DESCRIPTION (provided by applicant): The University of Pittsburgh training grant "Basic and Translational Training in Obstetric- Fetal Pharmacology" aims to provide trainees essential classroom education as well as the research tools and clinical exposures necessary to bridge the longstanding impediments to meaningful and scientifically sound research in perinatal pharmacology. Both clinical and non-clinical research scientists who are committed to a research career and have a particular interest in the study of pregnant women and their fetuses will be recruited. Through a combination of targeted coursework, clinical exposure to pregnant women and research training, trainees will gain the fundamental tools required to carry out research related to pregnancy. This training will be linked to ongoing research in obstetrical pharmacology by research mentors and will lead to trainee-initiated research aimed at developing an area of research focus. The specific aims of our proposal are: 1) To consolidate the extensive resources at the University of Pittsburgh in basic sciences, epidemiology, pharmacology, women's health clinical research and education into a distinct training program in Obstetrical - Fetal pharmacology. 2) To recruit highly motivated, research-oriented, academically successful individuals for training in Obstetric- Fetal pharmacology. 3) To develop these recruits into individuals with sufficient skills to perform independent basic, translational and clinical research in maternal and fetal pharmacology and therapeutics. Many of the components for a successful program in Obstetrical-Fetal pharmacology already exist at the University of Pittsburgh. Collaborative research in perinatal pharmacology by the two investigators began over 26 years ago and is still robust culminating in our selection as one of four sites in the Obstetrical-Fetal Pharmacology Research Units (OPRU) Network. Basic, clinical and translational research focused on pregnancy at the University of Pittsburgh is broad based, extensive and well funded. Training of post-doctoral fellows is likewise extensive, well established, and highly successful. Fellowships in Maternal- Fetal Medicine, perinatal biology, pharmacology, genetics, reproductive infectious diseases already exist. The focus of the current proposal is to unify the extensive resources at the University of Pittsburgh under a single training program that emphasizes a multidisciplinary approach to training individuals in obstetric pharmacology. We will recruit and train 3 clinical and 5 non-clinical post-doctoral candidates through a combination of targeted coursework in pharmacology and clinical research methodologies, clinical practicums and laboratory work with experienced clinical, basic and translational researchers in obstetrical pharmacology. PUBLIC HEALTH RELEVANCE: The most vulnerable population in our society, pregnant women (and their fetuses) receive limited scientific information or guidance about medications they are prescribed. The paucity of scientific investigation in pregnancy-related pharmacology is in large part due to a lack of interest by the pharmaceutical industry and a dearth of investigators at academic institutions. Training programs that unify disparate interest and training in obstetrics and pharmacology are sorely needed to address this critical deficiency.