Pregnancy and Drug Metabolizing Enzymes and Transporters

描述(由申请人提供)：本建议的目的是在匹兹堡大学建立一个产科-胎儿-药理学研究单位(OPRU)，并总结申请人的OPRU的组成部分。他们将表明愿意与其他OPRU合作，建立OPRU网络，以确定和研究与怀孕期间使用药剂有关的常见问题。它们提供了三种协议供网络评估，以供将来探索。 匹兹堡OPRU由一个大型临床机构(玛吉妇女医院)组成，有8000多名产妇和一系列患有医疗或产科并发症的妇女。马吉的儿童权利中心卫星为招募和研究孕妇提供了最佳地点。这些临床设施与临床药理学中心(CCP)相连，该中心提供经典药理学分析的核心实验室和基因分型、信使核糖核酸表达和测序终点测量的药物遗传学实验室。一个蛋白质组学实验室也与CCP有关。除了这些临床和分析资源外，还有一个寄养在玛吉妇女医院的繁殖恒河猴群体。基础科学部分完成了匹兹堡OPRU。一批不同的基础科学家和临床研究人员一直在通过CCP进行互动，并将为他们的OPRU增加相当大的广度和深度。 匹兹堡OPRU的领导层提供了一个多样化和经验丰富的研究小组，他们在母婴药理学领域有着长期的合作和研究历史。领导层在合作努力方面有经验，并准备与其他OPRU合作开展合作研究。

DESCRIPTION (provided by applicant): The purpose of this proposal is to establish an Obstetric-Fetal-Pharmacology Research Unit (OPRU) at the University of Pittsburgh and to summarize the components of the applicant's OPRU. They will demonstrate their willingness to cooperate with other OPRUs to establish a Network of OPRUs to identify and study common problems related to the use of pharmacologic agents during pregnancy. They provide three protocols for assessment by the Network for future exploration. The Pittsburgh OPRU is composed of a large clinical facility (Magee-Womens Hospital) with more than 8000 deliveries and a wide array of women with medical or obstetric complications. A CRC satellite at Magee provides an optimal site for recruitment and study of pregnant women. These clinical facilities are linked to the Center for Clinical Pharmacology (CCP), which provides a core laboratory for classical pharmacology analyses and a pharmacogenetic laboratory for genotyping, mRNA expression and sequencing endpoint measurements. A proteomics laboratory is also linked to the CCP. In addition to these clinical and analytical resources is a breeding rhesus monkey colony housed at Magee-Womens Hospital. A basic science component completes the Pittsburgh OPRU. A diverse group of basic scientists and clinical researchers has been interacting through the CCP and will add considerable breadth and depth to their OPRU. The leadership of the Pittsburgh OPRU provides a diverse and experienced group of researchers with a long history of collaboration and investigation in the area of maternal-fetal pharmacology. The leadership has experience in collaborative endeavors and is prepared to cooperate with other OPRUs to conduct collaborative research.