Pregnancy and Drug Metabolizing Enzymes and Transporters
怀孕与药物代谢酶和转运蛋白
基本信息
- 批准号:7295297
- 负责人:
- 金额:$ 15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-07-01 至 2009-04-30
- 项目状态:已结题
- 来源:
- 关键词:antihypertensive agentscardiovascular disordercardiovascular disorder chemotherapyclinical researchclinical trialscord bloodcytochrome P450drug administration rate /durationembryo /fetusembryo /fetus pharmacologyenzyme activityfemalehormone regulation /control mechanismhuman fetus tissuehuman genetic material taghuman pregnant subjecthuman subjecthuman therapy evaluationliver metabolismmental disorder chemotherapymental disordersondansetronparoxetinepatient oriented researchpharmacogeneticspharmacokineticsplacentapregnancyreproductive hormoneserotonin inhibitorsertralinetransport proteinswomen&aposs health
项目摘要
DESCRIPTION (provided by applicant): The purpose of this proposal is to establish an Obstetric-Fetal-Pharmacology Research Unit (OPRU) at the University of Pittsburgh and to summarize the components of the applicant's OPRU. They will demonstrate their willingness to cooperate with other OPRUs to establish a Network of OPRUs to identify and study common problems related to the use of pharmacologic agents during pregnancy. They provide three protocols for assessment by the Network for future exploration.
The Pittsburgh OPRU is composed of a large clinical facility (Magee-Womens Hospital) with more than 8000 deliveries and a wide array of women with medical or obstetric complications. A CRC satellite at Magee provides an optimal site for recruitment and study of pregnant women. These clinical facilities are linked to the Center for Clinical Pharmacology (CCP), which provides a core laboratory for classical pharmacology analyses and a pharmacogenetic laboratory for genotyping, mRNA expression and sequencing endpoint measurements. A proteomics laboratory is also linked to the CCP. In addition to these clinical and analytical resources is a breeding rhesus monkey colony housed at Magee-Womens Hospital. A basic science component completes the Pittsburgh OPRU. A diverse group of basic scientists and clinical researchers has been interacting through the CCP and will add considerable breadth and depth to their OPRU.
The leadership of the Pittsburgh OPRU provides a diverse and experienced group of researchers with a long history of collaboration and investigation in the area of maternal-fetal pharmacology. The leadership has experience in collaborative endeavors and is prepared to cooperate with other OPRUs to conduct collaborative research.
描述(由申请人提供):本提案的目的是在匹兹堡大学建立一个产科-胎儿药理学研究单位(OPRU),并总结申请人OPRU的组成部分。它们将表示愿意与其他门诊医务所合作,建立一个门诊医务所网络,以查明和研究与怀孕期间使用药物制剂有关的共同问题。它们提供了三种协议供网络评估,以供将来探索。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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STEVE N CARITIS其他文献
STEVE N CARITIS的其他文献
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{{ truncateString('STEVE N CARITIS', 18)}}的其他基金
Pharmacologically-based Strategies for Buprenorphine Treatment During Pregnancy
妊娠期丁丙诺啡治疗的药理学策略
- 批准号:
10152373 - 财政年份:2018
- 资助金额:
$ 15万 - 项目类别:
Pharmacologically-based Strategies for Buprenorphine Treatment During Pregnancy
妊娠期丁丙诺啡治疗的药理学策略
- 批准号:
10418618 - 财政年份:2018
- 资助金额:
$ 15万 - 项目类别:
Training in Basic and Clinical Pharmacology in Pregnancy
妊娠期基础和临床药理学培训
- 批准号:
8657471 - 财政年份:2012
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$ 15万 - 项目类别:
Training in Basic and Clinical Pharmacology in Pregnancy
妊娠期基础和临床药理学培训
- 批准号:
8459949 - 财政年份:2012
- 资助金额:
$ 15万 - 项目类别:
Training in Basic and Clinical Pharmacology in Pregnancy
妊娠期基础和临床药理学培训
- 批准号:
8267936 - 财政年份:2012
- 资助金额:
$ 15万 - 项目类别:
A RANDOMIZED CLINICAL TRIAL OF TREATMENT FOR MILD GESTATIONAL DIABETES
轻度妊娠糖尿病治疗的随机临床试验
- 批准号:
7201164 - 财政年份:2005
- 资助金额:
$ 15万 - 项目类别:
17 ALPHA-HYDROXYPROGESTERONE CAPROATE FOR PREVENTION OF PRETERM BIRTH
17 α-羟基黄体酮己酸酯用于预防早产
- 批准号:
7201175 - 财政年份:2005
- 资助金额:
$ 15万 - 项目类别:
COMBINED ANTIOXIDANT AND PREECLAMPSIA PREDICTION STUDIES (CAPPS)
抗氧化剂和先兆子痫联合预测研究 (CAPPS)
- 批准号:
7201163 - 财政年份:2005
- 资助金额:
$ 15万 - 项目类别:
Impact of Pregnancy on Drug Absorption, Disposition and End Organ Response
妊娠对药物吸收、处置和终末器官反应的影响
- 批准号:
8429391 - 财政年份:2004
- 资助金额:
$ 15万 - 项目类别:
Optimization of Drug Dosing in Pregnant Women through Research and Education
通过研究和教育优化孕妇药物剂量
- 批准号:
9310037 - 财政年份:2004
- 资助金额:
$ 15万 - 项目类别:
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