Pregnancy and Drug Metabolizing Enzymes and Transporters

描述（由申请人提供）：本提案旨在在匹兹堡大学建立产科-胎儿-药理学研究单位（OPRU），并总结申请人OPRU的组成部分。他们将表明他们愿意与其他OPRU合作，建立一个OPRU网络，以确定和研究与怀孕期间使用药物有关的常见问题。它们提供了三项协议，供网络为今后的勘探进行评估。 匹兹堡OPRU由一个大型临床设施（Magee妇女医院）组成，有8 000多名分娩和各种各样的患有医疗或产科并发症的妇女。马吉的一个CRC卫星为招募和研究孕妇提供了一个最佳地点。这些临床设施与临床药理学中心（CCP）相连，该中心提供经典药理学分析的核心实验室和基因分型、mRNA表达和测序终点测量的药物遗传学实验室。一个蛋白质组学实验室也与CCP有联系。除了这些临床和分析资源外，还有一个饲养恒河猴的群体，位于Mageee-Womens医院。一个基本的科学组成部分完成匹兹堡OPRU。基础科学家和临床研究人员组成的多元化小组一直在通过CCP进行互动，并将为其OPRU增加相当大的广度和深度。 匹兹堡OPRU的领导层提供了一个多元化和经验丰富的研究人员群体，在母胎药理学领域有着悠久的合作和调查历史。领导层具有合作努力的经验，并准备与其他OPRU合作进行合作研究。

DESCRIPTION (provided by applicant): The purpose of this proposal is to establish an Obstetric-Fetal-Pharmacology Research Unit (OPRU) at the University of Pittsburgh and to summarize the components of the applicant's OPRU. They will demonstrate their willingness to cooperate with other OPRUs to establish a Network of OPRUs to identify and study common problems related to the use of pharmacologic agents during pregnancy. They provide three protocols for assessment by the Network for future exploration. The Pittsburgh OPRU is composed of a large clinical facility (Magee-Womens Hospital) with more than 8000 deliveries and a wide array of women with medical or obstetric complications. A CRC satellite at Magee provides an optimal site for recruitment and study of pregnant women. These clinical facilities are linked to the Center for Clinical Pharmacology (CCP), which provides a core laboratory for classical pharmacology analyses and a pharmacogenetic laboratory for genotyping, mRNA expression and sequencing endpoint measurements. A proteomics laboratory is also linked to the CCP. In addition to these clinical and analytical resources is a breeding rhesus monkey colony housed at Magee-Womens Hospital. A basic science component completes the Pittsburgh OPRU. A diverse group of basic scientists and clinical researchers has been interacting through the CCP and will add considerable breadth and depth to their OPRU. The leadership of the Pittsburgh OPRU provides a diverse and experienced group of researchers with a long history of collaboration and investigation in the area of maternal-fetal pharmacology. The leadership has experience in collaborative endeavors and is prepared to cooperate with other OPRUs to conduct collaborative research.