Neurobiology of pain experiences in youth in the ABCD study

ABCD研究中青年疼痛体验的神经生物学 项目摘要 慢性疼痛是一个巨大的公共卫生问题，对心理健康的影响广泛，危害深远 和身体健康，造成巨大的社会成本。在慢性疼痛综合征中，许多是 在女性中更为普遍，在青春期发病率急剧上升。儿科慢性疼痛是 它本身就很昂贵，不幸的是，在青春期患有慢性疼痛的人很可能会有疼痛 坚持到成年，并经历高比例的共病抑郁和药物滥用。确实有 慢性疼痛的已知危险因素，包括女性性行为、低水平的体力活动、抑郁的情绪以及 睡眠障碍，但疼痛持续的机制尚未很好地理解，特别是从 神经生物学观点。此外，在儿科人群中，神经生物学的研究很少。 在足够大的样本中疼痛的相关性，以及对疼痛轨迹的有限的前瞻性研究 整合了神经生物学数据。在这项研究中，我们将前瞻性地检查神经生物学和 青春期与疼痛相关的生物-心理-社会特征，这是发展的关键时期 情绪和调节功能，以预测疼痛维持和相关的影响随着时间的推移。去做 为此，我们将利用参加ABCD的估计n=3773名11-12岁青少年(49%为女性)的数据 报告在过去一个月中经历疼痛的研究，以及同等大小的比较样本，匹配 关于年龄和人口统计变量，他们报告在过去的一个月里没有感觉到疼痛。我们将利用休息时间 状态、功能和结构神经成像，以及风险因素的全面表型评估 在这个大样本中，确定疼痛体验的神经生物学相关性的基线。到时候我们会的 检查疼痛随时间变化的轨迹(报告的疼痛强度、疼痛程度增加或减少 位置和疼痛相关活动限制)，并利用假设驱动的纵向建模方法 识别基于大脑和生物心理社会的危险因素，预测持续和不断升级的疼痛。结果将 告知我们对发育的神经生物学和相关生物、心理和社会风险的基本理解 在一个关键的发育期，慢性疼痛的风险，并将为筛查方案和 有针对性的预防性干预。

Neurobiology of pain experiences in youth in the ABCD study Project Summary Chronic pain is a massive public health problem, with wide impact and profound detrimental effects on mental and physical health of those afflicted, resulting in large societal cost. Of chronic pain syndromes, many are more prevalent in females, and incidence increases dramatically during adolescence. Pediatric chronic pain is costly in its own right, and unfortunately individuals with chronic pain in adolescence are likely to have pain persist into adulthood, and experience high rates of comorbid depression and substance abuse. There are known risk factors for chronic pain, including female sex, low levels of physical activity, depressed mood, and sleep disturbance, but mechanisms underlying pain persistence are not well understood, particularly from a neurobiological perspective. Additionally, in pediatric populations there is minimal research on neurobiological correlates of pain in sufficiently large samples, and limited prospective research on pain trajectories incorporating neurobiological data. In this study, we will prospectively examine neurobiological and biopsychosocial features associated with pain during adolescence, a critical period for development of emotional and regulatory functioning, to predict pain maintenance and associated impacts over time. To do this, we will utilize data from an estimated n=3773 11-12 year olds (49% female) participating in the ABCD Study who report experiencing pain in the past month, as well as an equal-sized comparison sample, matched on age and demographic variables, who report experiencing no pain in the past month. We will utilize resting state, functional, and structural neuroimaging, and comprehensive phenotypic assessment of risk factors at baseline to characterize the neurobiological correlates of pain experiences in this large sample. We will then examine pain trajectories over time (maintenance, increases, or decreases in reports of pain intensity, pain locations, and pain-related activity limitations), and utilize hypothesis-driven longitudinal modeling approaches to identify brain-based and biopsychosocial risk factors predicting sustained and escalating pain. Results will inform our fundamental understanding of neurobiological and related biopsychosocial risk for the development of chronic pain during a key developmental period, and will inform development of screening protocols and targeted preventive interventions.