3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging

3D 光声断层扫描 (PAT) 和动态对比增强 PAT 乳腺成像

• 批准号: 8297411
• 负责人: ROBERT A KRUGER
• 金额: $ 67.4万
• 依托单位: OPTOSONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8297411
• 关键词: Age; Age-Years; Architecture; Benign; Biological Markers; Blood Vessels; Blood flow; Bolus Infusion; Breast; Breast Cancer Detection; Characteristics; Chest wall structure; Clinical; Clinical Research; Clinical Sensitivity; Collaborations; Core Biopsy; Digital Mammography; Dimensions; Excision biopsy; Faculty; Genetic; Goals; Gold; Grant; Hemoglobin; Image; Imagery; Imaging Techniques; Imaging technology; Indocyanine Green; Injection of therapeutic agent; Ionizing radiation; Joints; Light; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammography; Mechanics; Medical center; Modality; Morphology; Nipples; North Carolina; Pathology; Patients; Pattern; Perfusion; Population; Predisposition; Reader; Recruitment Activity; Research; Research Personnel; Resolution; Roentgen Rays; Scanning; Schedule; Screening procedure; Sensitivity and Specificity; System; Target Populations; Testing; Transducers; Translating; Ultrasonography; Universities; Woman; X-Ray Computed Tomography; absorption; base; breast cancer diagnosis; data acquisition; density; design; design and construction; detector; diagnostic accuracy; interest; malignant breast neoplasm; medical schools; millimeter; optical imaging; patient population; population based; tomography; tumor

DESCRIPTION (provided by applicant): In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in patient populations for whom X-ray mammography is less sensitive. This platform will allow clinicians to assess two distinct biomarkers of breast cancer - hemoglobin distribution and blood flow within suspicious masses - in women with dense breast, women < 50 years of age, and those with a genetic or familial predisposition to breast cancer. Two new imaging technologies will be integrated into a single platform: 3D photoacoustic computed tomography (PAT) for imaging optical absorption; and, Dynamic, contrast-enhanced PAT (DCE-PAT) for quantifying blood flow and perfusion in suspicious masses. Both modalities will be co-registered spatially as they share conformal detector geometries. Our goal is to demonstrate 1.0 millimeter spatial resolution for imaging hemoglobin throughout the whole breast, compressed against the chest wall to < 5 cm, and to quantify blood flow within suspicious masses with spatial resolution 0.5 mm. The clinical utility of this new imaging technology will be evaluated through several, clinical studies. PUBLIC HEALTH RELEVANCE: In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in woman with dense breasts, women < 50 years of age, or those with a genetic or familial predisposition to breast cancer. The platform will employ light (near infrared), rather than x rays, to detect and characterize breast cancer. If we are successful, breast cancer detection rates will increase in this patient population for whom X-ray mammography performs poorly.

描述（由申请人提供）：与北卡罗来纳大学医学院的教职员工合作，OptoSonics提出开发和验证一种新的临床成像平台，用于对x射线乳房x光摄影不太敏感的患者群体进行乳腺癌筛查。该平台将允许临床医生评估乳腺癌的两种不同的生物标志物——血红蛋白分布和可疑肿块内的血流——在致密乳腺、年龄< 50岁的女性和具有乳腺癌遗传或家族易感性的女性中。两种新的成像技术将集成到一个单一的平台：用于成像光学吸收的3D光声计算机断层扫描（PAT）；动态，对比增强PAT （DCE-PAT）用于定量可疑肿块的血流和灌注。这两种模式将在空间上共同注册，因为它们共享共形探测器几何形状。我们的目标是展示1.0毫米的空间分辨率，用于成像整个乳房的血红蛋白，紧贴胸壁压缩到< 5厘米，并以0.5毫米的空间分辨率量化可疑肿块内的血流。这项新成像技术的临床应用将通过几项临床研究进行评估。