3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging

3D 光声断层扫描 (PAT) 和动态对比增强 PAT 乳腺成像

• 批准号: 8297411
• 负责人: ROBERT A KRUGER
• 金额: $ 67.4万
• 依托单位: OPTOSONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8297411
• 关键词: Age; Age-Years; Architecture; Benign; Biological Markers; Blood Vessels; Blood flow; Bolus Infusion; Breast; Breast Cancer Detection; Characteristics; Chest wall structure; Clinical; Clinical Research; Clinical Sensitivity; Collaborations; Core Biopsy; Digital Mammography; Dimensions; Excision biopsy; Faculty; Genetic; Goals; Gold; Grant; Hemoglobin; Image; Imagery; Imaging Techniques; Imaging technology; Indocyanine Green; Injection of therapeutic agent; Ionizing radiation; Joints; Light; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammography; Mechanics; Medical center; Modality; Morphology; Nipples; North Carolina; Pathology; Patients; Pattern; Perfusion; Population; Predisposition; Reader; Recruitment Activity; Research; Research Personnel; Resolution; Roentgen Rays; Scanning; Schedule; Screening procedure; Sensitivity and Specificity; System; Target Populations; Testing; Transducers; Translating; Ultrasonography; Universities; Woman; X-Ray Computed Tomography; absorption; base; breast cancer diagnosis; data acquisition; density; design; design and construction; detector; diagnostic accuracy; interest; malignant breast neoplasm; medical schools; millimeter; optical imaging; patient population; population based; tomography; tumor

DESCRIPTION (provided by applicant): In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in patient populations for whom X-ray mammography is less sensitive. This platform will allow clinicians to assess two distinct biomarkers of breast cancer - hemoglobin distribution and blood flow within suspicious masses - in women with dense breast, women < 50 years of age, and those with a genetic or familial predisposition to breast cancer. Two new imaging technologies will be integrated into a single platform: 3D photoacoustic computed tomography (PAT) for imaging optical absorption; and, Dynamic, contrast-enhanced PAT (DCE-PAT) for quantifying blood flow and perfusion in suspicious masses. Both modalities will be co-registered spatially as they share conformal detector geometries. Our goal is to demonstrate 1.0 millimeter spatial resolution for imaging hemoglobin throughout the whole breast, compressed against the chest wall to < 5 cm, and to quantify blood flow within suspicious masses with spatial resolution 0.5 mm. The clinical utility of this new imaging technology will be evaluated through several, clinical studies. PUBLIC HEALTH RELEVANCE: In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in woman with dense breasts, women < 50 years of age, or those with a genetic or familial predisposition to breast cancer. The platform will employ light (near infrared), rather than x rays, to detect and characterize breast cancer. If we are successful, breast cancer detection rates will increase in this patient population for whom X-ray mammography performs poorly.

描述（由申请人提供）：在与教师和工作人员在医学院的合作，OptoSonics提出开发和验证一种新的临床成像平台，乳腺癌筛查的患者人群的X射线乳腺摄影是不太敏感。该平台将允许临床医生评估乳腺癌的两种不同生物标志物-可疑肿块内的血红蛋白分布和血流-在致密乳腺妇女，50岁以下妇女以及具有遗传或家族易感性的乳腺癌妇女中。两种新的成像技术将集成到一个平台中：用于光学吸收成像的3D光声计算机断层扫描（PAT）;以及用于量化可疑肿块中血流和灌注的动态对比增强PAT（DCE-PAT）。两种模式将在空间上共同配准，因为它们共享适形探测器几何结构。我们的目标是证明1.0毫米的空间分辨率成像血红蛋白在整个乳房，对胸壁压缩到< 5厘米，并量化血流可疑肿块内的空间分辨率为0.5毫米。这种新的成像技术的临床效用将通过几个临床研究进行评估。 公共卫生相关性：OptoSonics与美国麻省理工学院医学院的教职员工合作，提议开发和验证一种新的临床成像平台，用于乳腺致密型女性、50岁以下女性或具有乳腺癌遗传或家族易感性的女性的乳腺癌筛查。该平台将使用光（近红外线）而不是x射线来检测和表征乳腺癌。如果我们成功的话，乳腺癌的检出率将在X射线乳腺摄影表现不佳的患者人群中增加。