3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging

3D 光声断层扫描 (PAT) 和动态对比增强 PAT 乳腺成像

• 批准号: 8634060
• 负责人: ROBERT A KRUGER
• 金额: $ 64.01万
• 依托单位: OPTOSONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8634060
• 关键词: Age; Age-Years; Architecture; Benign; Biological Markers; Blood Vessels; Blood flow; Bolus Infusion; Breast; Breast Cancer Detection; Characteristics; Chest wall structure; Clinical; Clinical Research; Clinical Sensitivity; Collaborations; Core Biopsy; Digital Mammography; Dimensions; Excision biopsy; Faculty; Genetic; Geometry; Goals; Gold; Grant; Hemoglobin; Image; Imagery; Imaging Techniques; Imaging technology; Indocyanine Green; Injection of therapeutic agent; Ionizing radiation; Joints; Light; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammography; Mechanics; Medical center; Modality; Morphology; Nipples; North Carolina; Pathology; Patients; Pattern; Perfusion; Population; Predisposition; Reader; Recruitment Activity; Research; Research Personnel; Resolution; Roentgen Rays; Scanning; Schedule; Sensitivity and Specificity; System; Target Populations; Testing; Transducers; Translating; Ultrasonography; Universities; Woman; X-Ray Computed Tomography; absorption; base; breast cancer diagnosis; data acquisition; density; design; design and construction; detector; diagnostic accuracy; interest; malignant breast neoplasm; medical schools; millimeter; optical imaging; patient population; photoacoustic imaging; population based; public health relevance; screening; tomography; tumor

DESCRIPTION (provided by applicant): In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in patient populations for whom X-ray mammography is less sensitive. This platform will allow clinicians to assess two distinct biomarkers of breast cancer - hemoglobin distribution and blood flow within suspicious masses - in women with dense breast, women < 50 years of age, and those with a genetic or familial predisposition to breast cancer. Two new imaging technologies will be integrated into a single platform: 3D photoacoustic computed tomography (PAT) for imaging optical absorption; and, Dynamic, contrast-enhanced PAT (DCE-PAT) for quantifying blood flow and perfusion in suspicious masses. Both modalities will be co-registered spatially as they share conformal detector geometries. Our goal is to demonstrate 1.0 millimeter spatial resolution for imaging hemoglobin throughout the whole breast, compressed against the chest wall to < 5 cm, and to quantify blood flow within suspicious masses with spatial resolution 0.5 mm. The clinical utility of this new imaging technology will be evaluated through several, clinical studies.

描述（由申请人提供）：在与教师和工作人员在医学院的合作，OptoSonics提出开发和验证一种新的临床成像平台，乳腺癌筛查的患者人群的X射线乳腺摄影是不太敏感。该平台将允许临床医生评估乳腺癌的两种不同生物标志物-可疑肿块内的血红蛋白分布和血流-在致密乳腺妇女，50岁以下妇女以及具有遗传或家族易感性的乳腺癌妇女中。两种新的成像技术将集成到一个平台中：用于光学吸收成像的3D光声计算机断层扫描（PAT）;以及用于量化可疑肿块中血流和灌注的动态对比增强PAT（DCE-PAT）。两种模式将在空间上共同配准，因为它们共享适形探测器几何结构。我们的目标是证明1.0毫米的空间分辨率成像血红蛋白在整个乳房，对胸壁压缩到< 5厘米，并量化血流可疑肿块内的空间分辨率为0.5毫米。这种新的成像技术的临床效用将通过几个临床研究进行评估。