3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging
3D 光声断层扫描 (PAT) 和动态对比增强 PAT 乳腺成像
基本信息
- 批准号:8634060
- 负责人:
- 金额:$ 64.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-06-01 至 2017-03-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAge-YearsArchitectureBenignBiological MarkersBlood VesselsBlood flowBolus InfusionBreastBreast Cancer DetectionCharacteristicsChest wall structureClinicalClinical ResearchClinical SensitivityCollaborationsCore BiopsyDigital MammographyDimensionsExcision biopsyFacultyGeneticGeometryGoalsGoldGrantHemoglobinImageImageryImaging TechniquesImaging technologyIndocyanine GreenInjection of therapeutic agentIonizing radiationJointsLightMagnetic Resonance ImagingMalignant - descriptorMalignant NeoplasmsMammographyMechanicsMedical centerModalityMorphologyNipplesNorth CarolinaPathologyPatientsPatternPerfusionPopulationPredispositionReaderRecruitment ActivityResearchResearch PersonnelResolutionRoentgen RaysScanningScheduleSensitivity and SpecificitySystemTarget PopulationsTestingTransducersTranslatingUltrasonographyUniversitiesWomanX-Ray Computed Tomographyabsorptionbasebreast cancer diagnosisdata acquisitiondensitydesigndesign and constructiondetectordiagnostic accuracyinterestmalignant breast neoplasmmedical schoolsmillimeteroptical imagingpatient populationphotoacoustic imagingpopulation basedpublic health relevancescreeningtomographytumor
项目摘要
DESCRIPTION (provided by applicant): In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in patient populations for whom X-ray mammography is less sensitive. This platform will allow clinicians to assess two distinct biomarkers of breast cancer - hemoglobin distribution and blood flow within suspicious masses - in women with dense breast, women < 50 years of age, and those with a genetic or familial predisposition to breast cancer. Two new imaging technologies will be integrated into a single platform: 3D photoacoustic computed tomography (PAT) for imaging optical absorption; and, Dynamic, contrast-enhanced PAT (DCE-PAT) for quantifying blood flow and perfusion in suspicious masses. Both modalities will be co-registered spatially as they share conformal detector geometries. Our goal is to demonstrate 1.0 millimeter spatial resolution for imaging hemoglobin throughout the whole breast, compressed against the chest wall to < 5 cm, and to quantify blood flow within suspicious masses with spatial resolution 0.5 mm. The clinical utility of this new imaging technology will be evaluated through several, clinical studies.
描述(由申请人提供):在与教师和工作人员在医学院的合作,OptoSonics提出开发和验证一种新的临床成像平台,乳腺癌筛查的患者人群的X射线乳腺摄影是不太敏感。该平台将允许临床医生评估乳腺癌的两种不同生物标志物-可疑肿块内的血红蛋白分布和血流-在致密乳腺妇女,50岁以下妇女以及具有遗传或家族易感性的乳腺癌妇女中。两种新的成像技术将集成到一个平台中:用于光学吸收成像的3D光声计算机断层扫描(PAT);以及用于量化可疑肿块中血流和灌注的动态对比增强PAT(DCE-PAT)。两种模式将在空间上共同配准,因为它们共享适形探测器几何结构。我们的目标是证明1.0毫米的空间分辨率成像血红蛋白在整个乳房,对胸壁压缩到< 5厘米,并量化血流可疑肿块内的空间分辨率为0.5毫米。这种新的成像技术的临床效用将通过几个临床研究进行评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT A KRUGER其他文献
ROBERT A KRUGER的其他文献
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{{ truncateString('ROBERT A KRUGER', 18)}}的其他基金
Instrument and Method for Forming Three-Dimensional Ultrasound Images of the Brea
用于形成布雷亚三维超声图像的仪器和方法
- 批准号:
8711846 - 财政年份:2014
- 资助金额:
$ 64.01万 - 项目类别:
3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging
3D 光声断层扫描 (PAT) 和动态对比增强 PAT 乳腺成像
- 批准号:
8297411 - 财政年份:2012
- 资助金额:
$ 64.01万 - 项目类别:
3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging
3D 光声断层扫描 (PAT) 和动态对比增强 PAT 乳腺成像
- 批准号:
8473832 - 财政年份:2012
- 资助金额:
$ 64.01万 - 项目类别:
HYPR-Spectral PCT for Preclinical Imaging
用于临床前成像的 HYPR-Spectral PCT
- 批准号:
7534898 - 财政年份:2008
- 资助金额:
$ 64.01万 - 项目类别:
3-D Thermoacoustic Computed Tomography/Molecular Imaging
3-D 热声计算机断层扫描/分子成像
- 批准号:
6858670 - 财政年份:2004
- 资助金额:
$ 64.01万 - 项目类别:
3-D Thermoacoustic Computed Tomography/Molecular Imaging
3-D 热声计算机断层扫描/分子成像
- 批准号:
6992695 - 财政年份:2004
- 资助金额:
$ 64.01万 - 项目类别:
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