3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging

3D 光声断层扫描 (PAT) 和动态对比增强 PAT 乳腺成像

基本信息

批准号：
8634060
负责人：
ROBERT A KRUGER
金额：
$ 64.01万
依托单位：
OPTOSONICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8634060
关键词：
Age Age-Years Architecture Benign Biological Markers Blood Vessels Blood flow Bolus Infusion Breast Breast Cancer Detection Characteristics Chest wall structure Clinical Clinical Research Clinical Sensitivity Collaborations Core Biopsy Digital Mammography Dimensions Excision biopsy Faculty Genetic Geometry Goals Gold Grant Hemoglobin Image Imagery Imaging Techniques Imaging technology Indocyanine Green Injection of therapeutic agent Ionizing radiation Joints Light Magnetic Resonance Imaging Malignant - descriptor Malignant Neoplasms Mammography Mechanics Medical center Modality Morphology Nipples North Carolina Pathology Patients Pattern Perfusion Population Predisposition Reader Recruitment Activity Research Research Personnel Resolution Roentgen Rays Scanning Schedule Sensitivity and Specificity System Target Populations Testing Transducers Translating Ultrasonography Universities Woman X-Ray Computed Tomography absorption base breast cancer diagnosis data acquisition density design design and construction detector diagnostic accuracy interest malignant breast neoplasm medical schools millimeter optical imaging patient population photoacoustic imaging population based public health relevance screening tomography tumor

项目摘要

DESCRIPTION (provided by applicant): In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in patient populations for whom X-ray mammography is less sensitive. This platform will allow clinicians to assess two distinct biomarkers of breast cancer - hemoglobin distribution and blood flow within suspicious masses - in women with dense breast, women < 50 years of age, and those with a genetic or familial predisposition to breast cancer. Two new imaging technologies will be integrated into a single platform: 3D photoacoustic computed tomography (PAT) for imaging optical absorption; and, Dynamic, contrast-enhanced PAT (DCE-PAT) for quantifying blood flow and perfusion in suspicious masses. Both modalities will be co-registered spatially as they share conformal detector geometries. Our goal is to demonstrate 1.0 millimeter spatial resolution for imaging hemoglobin throughout the whole breast, compressed against the chest wall to < 5 cm, and to quantify blood flow within suspicious masses with spatial resolution 0.5 mm. The clinical utility of this new imaging technology will be evaluated through several, clinical studies.

描述（由申请人提供）：与UNC医学学院的教职员工合作，Optosonics提议开发和验证一个新的临床成像平台，以供X射线乳房X线摄影较少敏感的患者乳腺癌筛查。该平台将允许临床医生评估乳腺癌的两个不同的生物标志物 - 血红蛋白分布和可疑肿块中的血液流动 - 乳房密集的女性，妇女少于50岁，以及患有遗传或家族性的乳腺癌的女性。两种新的成像技术将集成到一个平台中：用于成像光吸收的3D光声计算机断层扫描（PAT）；以及动态，对比增强的PAT（DCE-PAT），用于量化可疑质量中的血流和灌注。两种方式将在共享保形检测器几何形状时在空间上共同注册。我们的目标是展示1.0毫米空间分辨率，用于整个乳房成像血红蛋白，在胸壁上压缩至<5 cm，并量化以空间分辨率为0.5 mm的可疑质量中的血流。这种新成像技术的临床实用性将通过几项临床研究进行评估。