3D Photoacoustic Tomography (PAT)and Dynamic Contrast-Enhanced PAT Breast Imaging

描述(由申请人提供)：OptoSonics与北卡罗来纳大学医学院的教职员工合作，提议开发和验证一种新的临床成像平台，用于对X光乳房X光摄影不太敏感的患者群体进行乳腺癌筛查。这一平台将允许临床医生评估乳腺癌的两个不同的生物标志物--血红蛋白在可疑肿块中的分布和血流--在乳房致密的妇女、50岁的妇女和那些有乳腺癌遗传或家族易感性的妇女中。两种新的成像技术将整合到一个平台中：3D光声计算机断层扫描(PAT)用于成像光学吸收；动态对比增强PAT(DCE-PAT)用于量化可疑肿块的血流和灌注。这两种模式将在空间上共同登记，因为它们共享共形探测器几何形状。我们的目标是展示1.0毫米的空间分辨率，用于整个乳房的血红蛋白成像，对胸壁压缩至5厘米，并以0.5毫米的空间分辨率量化可疑肿块内的血流。这项新的成像技术的临床实用性将通过几项临床研究进行评估。

DESCRIPTION (provided by applicant): In collaboration with faculty and staff at the UNC School of Medicine, OptoSonics proposes to develop and validate a new clinical imaging platform for breast cancer screening in patient populations for whom X-ray mammography is less sensitive. This platform will allow clinicians to assess two distinct biomarkers of breast cancer - hemoglobin distribution and blood flow within suspicious masses - in women with dense breast, women < 50 years of age, and those with a genetic or familial predisposition to breast cancer. Two new imaging technologies will be integrated into a single platform: 3D photoacoustic computed tomography (PAT) for imaging optical absorption; and, Dynamic, contrast-enhanced PAT (DCE-PAT) for quantifying blood flow and perfusion in suspicious masses. Both modalities will be co-registered spatially as they share conformal detector geometries. Our goal is to demonstrate 1.0 millimeter spatial resolution for imaging hemoglobin throughout the whole breast, compressed against the chest wall to < 5 cm, and to quantify blood flow within suspicious masses with spatial resolution 0.5 mm. The clinical utility of this new imaging technology will be evaluated through several, clinical studies.