Early Estimation of Breat Tumor Response to Therapy
乳腺肿瘤治疗反应的早期估计
基本信息
- 批准号:8376470
- 负责人:
- 金额:$ 21.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-07-15 至
- 项目状态:未结题
- 来源:
- 关键词:AffectAlgorithmsAnimal ExperimentsAnimalsApoptosisBackBiological MarkersBrainBrain NeoplasmsBreastBreast Cancer CellBudgetsCaliberCancer PatientCell DeathCellsClinicalComplexConsentDataData SetDetectionDevelopmentDiffusionDiffusion Magnetic Resonance ImagingDoctor of PhilosophyEpidemiologic MethodsExcisionFailureGoalsGraphGrowthHarvestHeadHematomaHistologyHumanImageImageryImplantInstructionInternetInterventionLeadLengthMagnetic Resonance ImagingMalignant NeoplasmsMammary NeoplasmsMammographyManualsMapsMeasuresMethodsMetricMinorModelingModificationMusNamesNecrosisNeoadjuvant TherapyNeoplasm MetastasisNoiseOncologistOperative Surgical ProceduresOutcomePathologistPatientsPerformancePerfusionPlant RootsPrimary NeoplasmPrincipal InvestigatorProcessProliferatingPublicationsPublished CommentPublishingRattusReadingRecruitment ActivityRelative (related person)Research PersonnelResolutionSamplingScanningScheduleSeedsServicesSimulateSlideSolid NeoplasmSolutionsStagingStaining methodStainsStratificationStructureSystemTechniquesTestingTherapeuticTimeTumor VolumeWorkbasebody systemcancer imagingchemotherapydensityexperienceimprovedin vivoinclusion criteriainsightinterestmalignant breast neoplasmmultimodalityprognosticprogramsradiologistresearch studyresponsesuccesstooltrendtumorvector
项目摘要
In previously published work by local coinvestigators a fundamental correlation between the increase in the
quantitative MR apparent diffusion coefficient (ADC) measured over the pre- to early post-initiation therapy
interval and the response of various brain tumors has been recently demonstrated. This work was
demonstrated in the brains of both rats and humans and was based on a voxel-based analysis of change in
the scatter plots of ADC values between rigidly registered pre- and post-therapeutic ADC MRI exams. The
goal of this Project is to develop and refine registration techniques that not only demonstrate the same
correlation exists in breast cancer as an early biomarker of cell death and potential surrogate for clinical
outcome, but also increase the accuracy of such techniques by including perfusion-related computed
parameters, and implementing accurate, automatic warping registration techniques. In addition to following
the lead of the previous work which demonstrated the correlation using epidemiological methods, e.g.
successful stratification of Kaplan-Meier plots based on ADC changes within volumes of interest defined by
oncologists in both animals and humans, we will extend the approach to eliminate the need for multiple
definition of gross volumes of interest by oncologists and improve the performance of the measure within
heterogeneous tumors. Additionally for a subset of data we will carry histological results back to the in vivo
images for correlation with histological truth.
RELEVANCE (See instructions): .
The development of accurate and automatic registration of interval MRI diffusion breast exams will help
individuate neoadjuvant chemotherapy for breast cancer patients by improving the accuracy of estimating
tumors' early response (1-3 weeks) to therapy.
在当地合作者先前发表的工作中,研究人员发现
项目成果
期刊论文数量(0)
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专利数量(0)
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Charles Raymond Meyer其他文献
Charles Raymond Meyer的其他文献
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{{ truncateString('Charles Raymond Meyer', 18)}}的其他基金
AUTOMATIC 3D REGISTRATION FOR ENHANCED CANCER MANAGEMENT
自动 3D 配准以增强癌症管理
- 批准号:
6608879 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
Automatic Three Dimensional (3D) Registration for Enhanced Cancer Management
自动三维 (3D) 配准以增强癌症管理
- 批准号:
8445391 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
Automatic Three Dimensional (3D) Registration for Enhanced Cancer Management
自动三维 (3D) 配准以增强癌症管理
- 批准号:
8234852 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
AUTOMATIC 3D REGISTRATION FOR ENHANCED CANCER MANAGEMENT
自动 3D 配准以增强癌症管理
- 批准号:
7116974 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
Automatic Three Dimensional (3D) Registration for Enhanced Cancer Management
自动三维 (3D) 配准以增强癌症管理
- 批准号:
7611736 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
Early Estimation of Breat Tumor Response to Therapy
乳腺肿瘤治疗反应的早期估计
- 批准号:
8445392 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
Automatic Three Dimensional (3D) Registration for Enhanced Cancer Management
自动三维 (3D) 配准以增强癌症管理
- 批准号:
8376476 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
Automatic Three Dimensional (3D) Registration for Enhanced Cancer Management
自动三维 (3D) 配准以增强癌症管理
- 批准号:
7802144 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
AUTOMATIC 3D REGISTRATION FOR ENHANCED CANCER MANAGEMENT
自动 3D 配准以增强癌症管理
- 批准号:
6932488 - 财政年份:2002
- 资助金额:
$ 21.7万 - 项目类别:
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