Digital Imaging Processing Core

核心C：数字图像处理 数字图像处理核心的目标是继续为所有项目提供分析工具。这些 独特的图像分析工具是必要的无偏，准确，定量分析的时间 实验室动物和人类患者的单模态和多模态MRI数据集的体积变化。 目前，所有MRI采集均独立于动物和人体所有间隔检查的权重 研究在第一次检查中完全自动配准到“参考”数据集，通常使用旋转 平移几何模型;这是使用现有软件工具的多模态配准问题。通常 T1加权的Gad后序列用作配准所有连续间期检查的参考 集.到目前为止，已经发现B1场校正是不必要的。如果收购 涉及诸如用于扩散或灌注加权成像的高梯度场，配准被 使用全仿射模型来完成，以支持由梯度引起的剪切的校正。目前所有 包括原始采集和配准数据集以及动物备份的人类扫描数据被 存储在核心的磁盘系统上在未来，所有的动物扫描将同样存储在核心的磁盘上 它可以通过TCP/IP或桑巴舞协议在100 Mb以太网上访问。核心当然是 负责维护数据完整性和备份。 该核心还将开发跨间隔跟踪治疗病变内体素位置的能力 使用高自由度翘曲的检查。这个动物和人类成像设施将支持 进一步研究表观扩散系数（ADC）以及其他参数的作用，例如， 灌注，作为治疗反应的潜在早期指标。此外，在A1修正案中， Core证明了将组织学映射回动物体内MRI体素的能力（其中整个头部暴露于MRI体素）。 体内MRI采集是可能的），仅使用固有扫描信息（即，没有任何植入的基准 kind）。 Pub.健康：总的来说，这项研究工作将为临床试验的启动提供理论依据， 用于治疗恶性脑肿瘤的分子靶向疗法的组合。此外，本发明还提供了一种方法， 将鉴定和验证用于早期评估治疗反应的成像生物标志物， 导致患者治疗个体化。 密歇根大学 安阿伯 PHS 398（2004年9月修订版）第3页/V表格第2页 主要研究者/项目负责人（最后，第一，中间）：ROSS，Brian D。 关键人员。参见说明。根据需要使用续页，以下列格式提供所需信息。 从首席研究员开始。按字母顺序列出所有其他关键人员，姓在前。 名称eRA Commons用户名组织在项目中的角色 Meyer，Charles Cmeyer密歇根大学核心主任 Bland，佩顿密歇根大学联合研究员 其他重要贡献者 名称组织在项目中的角色 人类胚胎干细胞（Human Embryonic Stem Cells） 如拟进行的项目涉及人类胚胎干细胞，请在以下列表中列出特定细胞系列的注册号： http://stemcells.nih.gov/reaistrv/index.asp.根据需要使用续页。 如果此时无法引用特定的行，请包含一个声明，说明将使用注册表中的一行。 细胞系 披露许可声明仅适用于SBIR/STTR。参见SBIR/STTR说明。Q是Q否 PHS 398（2004年9月修订版）第31$”页表格第2页-续 将下列各页依次编号 应用程序.不要使用后缀，如4a，4 b。 主要研究者/项目负责人（最后一位、第一位、中间一位）： 初步预算期的详细预算 仅直接成本Meyer/Core C 人员（仅适用于申请组织）% EFORT标牌 角色 APPT.上垒 项目名称（月）工资 核心 Meyer，Charles导演12 15%$160，680 联合调查 布兰德，佩顿12 25%$95，790 系统 Laderach，加里管理员12 5%$71，028 程序员 Geng，Hairong分析师12 100%$53，250 程序员 (TBN)技术12 100%$50，000 GSRA Eng. GSRA（TBN）12 100%$23，422 SUBTOT0.1““^ 咨询人费用 设备（逐项列出） 第2年和第3年购买 用品（按类别逐项列出） Mag Tape $500 旅行 核心总监1 - 2次/年 住院患者护理费用 门诊 改建和翻修（按类别逐项列出） 其他费用（按类别分列） GSRA学费和费用$14，772（秋季和冬季） 维护费$3，000 联合体/采购成本 作者：Brian D. 来自通 2006年1月12日2007年11月30日 申请金额（省略美分） 工资边缘。 申请福利总额 $24，102 $7，231 $31，333 $23，948 $7，184 $31，132 $3，551 $1，065 $4，616 $53，250 $15，975 $69，225 50，000美元15，000美元65，000美元 $23，422 $7，027 $30，449 $178，273 $53，482 $231，755 I 五百元 一千二百元 一万七千七百七十二美元 直接成本 初步预算直接费用小计 251,227 联合体/采购成本|设施和行政费用！ 初步预算期间直接费用共计 * 二十五万一千二百二十七| 仅限SBIR/STTR：收费 PHS 398（Rev. 09/04）Page Form第4页

Core C: Digital Image Processing The goals of the Digital Image Processing Core are to continue provide analytic tools for all projects. These unique image analysis tools are necessary for unbiased, accurate, quantitative analysis of temporal volumetric changes in single and multimodal MRI data sets of lab animals and human patients. Currently all MRI acquisitions independent of weightings for all interval exams of both animal and human studies are fully automatically registered to a "reference" data set in the first exam typically using a rotate- translate geometry model; this is a multimodality registration problem using existing software tools. Typically a T1-weighted, post-Gad sequence, is used as the reference for registering all successive interval exam sets. B1-field corrections have been found to be unnecessary thus far. In cases where the acquisitions involve high gradient fields such as those used for diffusion or perfusion weighted imaging, registrations are accomplished using a full affine model to support correction of shears caused by the gradients. Currently all human scan data including both original acquisitions and registered datasets, as well as animal backups, are stored on the Core's disk system. In the future all animal scans will be likewise stored on the Core's disks which can be accessed via TCP/IP or SAMBA protocols over 100 Mb ethernet. Of course the Core is responsible for maintaining data integrity and backup. The core will also develop the ability to track the positions of voxels within treated lesions across interval exams using high degree of freedom warpings. This facility for both animal and human imaging will support further investigation of the role of the apparent diffusion coefficient (ADC) as well as other parameters, e.g. perfusion, as potentially early indicators of therapeutic response. Additionally in the A1 amendment this Core demonstrated the ability to map histology back to in vivo MRI voxels for animals (where whole head ex vivo MRI acquisitions are possible) using only intrinsic scan information (i.e. no implanted fiducials of any kind). Pub. Health: Overall, this research effort willprovide therationale for initiation of clinical trials with combinations of molecularly targeted therapies for the treatment of malignant brain tumors. In addition, imaging biomarkers for early assessment of treatment response will be identified and validated which will lead to individualization of patient treatment. University of Michigan Ann Arbor, Michigan PHS 398(Rev. 09/04) Page 3/V Form Page 2 Principal Investigator/Program Director (Last, First, Middle): ROSS, Brian D. KEY PERSONNEL. See instructions. Usecontinuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Meyer, Charles Cmeyer University of Michigan Core Director Bland, Peyton University of Michigan Co-Investigator OTHER SIGNIFICANT CONTRIBUTORS Name Organization Role on Project Human Embryonic Stem Cells ^ No [~1 Yes If the proposed project involves human embryonic stem cells, list below the registration number of the specific cell llne(s) from the following list: http://stemcells.nih.gov/reaistrv/index.asp. Usecontinuationpages asneeded. If a specific line cannot be referenced at thistime, includea statement that one from the Registry will be used. Cell Line Disclosure Permission Statement Applicable toSBIR/STTR Onlv. See SBIR/STTR instructions. Q Yes Q No PHS 398 (Rev. 09/04) Page 31$" Form Page 2-continued Number the following pages consecutively throughout the application. Do not use suffixes such as 4a, 4b. Principal Investigator/Program Director (Last, first, middle): DETAILED BUDGET FOR INITIAL BUDGET PERIOD DIRECT COSTS ONLY Meyer/Core C PERSONNEL (Applicant organization only) % TYPE EFFORT INST. ROLE ON APPT. ON BASE NAME PROJECT (months) PROJ. SALARY Core Meyer, Charles Director 12 15% $160,680 Co-lnv. Bland, Peyton 12 25% $95,790 System Laderach, Gary Administrator 12 5% $71,028 Programmer Geng, Hairong Analyst 12 100% $53,250 Programmer (TBN) Technical 12 100% $50,000 GSRA Eng. GSRA (TBN) 12 100% $23,422 SUBTOT0.1 " "^ CONSULTANT COSTS EQUIPMENT (Itemize) Purchased in Years 2 & 3 SUPPLIES (Itemize bycategory) Mag Tape $500 TRAVEL 1 -2 Trips/year for Core Director PATIENT CARE COSTS INPATIENT OUTPATIENT ALTERATIONS AND RENOVATIONS (Itemize bycategory) OTHER EXPENSES (Itemize bycategory) GSRA Tuition & Fees $14,772 (Fall & Winter) Maintenance Fees $3,000 CONSORTIUM/CONTRACTUAL COSTS Ross, Brian D. FROM THROUGH 12/1/2006 11/30/2007 DOLLAR AMOUNT REQUESTED (omit cents) SALARY FRINGE . REQUESTED BENEFITS TOTALS $24,102 $7,231 $31,333 $23,948 $7,184 $31,132 $3,551 $1,065 $4,616 $53,250 $15,975 $69,225 $50,000 $15,000 $65,000 $23,422 $7,027 $30,449 $178,273 $53,482 $231,755 I $500 $1,200 $17,772 DIRECT COSTS SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PEF (Item 7a, FacePage) $ 251,227 CONSORTIUM/CONTRACTUAL COSTS | FACILITIES AND ADMINISTRATION COSTS! TOTAL DIRECTCOSTS FOR INITIAL BUDGET PERIOD $ I * 251 ,227 | SBIR/STTR Only: FEE REQUESTED PHS 398 (Rev. 09/04) Page Form Page 4