Digital Imaging Processing Core

核心C：数字图像处理 数字图像处理核心的目标是继续为所有项目提供分析工具。这些 独特的图像分析工具对于无偏、准确、定量的时间序列分析是必不可少的 实验动物和人类患者的单模式和多模式磁共振数据集的体积变化。 目前，所有的MRI采集与动物和人类的所有间隔检查的权重无关 在第一次检查中，检查通常使用轮换，完全自动注册到“参考”数据集。 转换几何模型；这是一个使用现有软件工具的多通道配准问题。通常 T1加权后Gad序列用作记录所有连续间隔检查的参考 布景。到目前为止，已经发现B1场校正是不必要的。在收购的情况下 涉及高梯度场，如用于扩散或灌注加权成像的那些，登记如下 使用完整的仿射模型来支持由梯度引起的剪切的校正。目前全部 人体扫描数据包括原始采集和注册数据集，以及动物备份 存储在核心的磁盘系统上。在未来，所有动物扫描都将同样存储在核心的磁盘上 它可以通过100Mb以太网上的TCP/IP或Samba协议来访问。当然，核心是 负责维护数据的完整性和备份。 核心还将开发跨间隔跟踪治疗皮损内体素位置的能力 使用高自由度翘曲的考试。这一用于动物和人体成像的设施将支持 进一步研究了表观扩散系数(ADC)以及其他参数的作用。 血流灌注，作为治疗反应的潜在早期指标。此外，在A1修正案中， Core展示了将组织学映射回动物体内MRI体素的能力(其中整个头部是 仅使用内部扫描信息(即，没有任何植入的基准 善良)。 酒吧。健康：总体而言，这项研究工作将为启动临床试验提供理论依据 分子靶向治疗恶性脑肿瘤的联合疗法。此外, 将识别和验证用于早期评估治疗反应的成像生物标记物，这将 导致患者治疗的个体化。 密歇根大学 安阿伯，密歇根州 小灵通398(09/04版)第3/V页表格第2页 首席研究员/项目主任(最后、第一、中间)：Ross，Brian D. 关键人员。请参阅说明。根据需要提供所需信息的第二页，格式如下。 从首席调查员开始。按字母顺序列出所有其他关键人员，姓氏在前。 名称时代共享用户名项目上的组织角色 密歇根大学查尔斯·迈耶核心主任 布兰德，密歇根佩顿大学共同研究员 其他重要贡献者 命名项目中的组织角色 人类胚胎干细胞^否[~1是 如果建议的项目涉及人类胚胎干细胞，请从以下列表中列出特定细胞(S)的注册号： Http://stemcells.nih.gov/reaistrv/index.asp.根据需要使用二次更新页面。 如果此时不能引用某一特定行，请附上一项声明，说明将使用书记官处的一行。 细胞系 适用于SBIR/STTR Onlv的披露许可声明。请参阅SBIR/STTR说明。Q是Q否 小灵通398(09/04版)第31页$“表第2页-续 从头到尾连续地给下面的页面编号 应用程序。不要使用诸如4a、4b之类的后缀。 首席调查员/项目总监(最后、第一、中间)： 初步预算期明细预算 直接成本仅为Meyer/Core C 人员(仅限申请组织)% 键入Effort Inst. 角色在 阿普特。在基地上 项目名称(月)项目。工资 堆芯 查尔斯·迈耶导演12 15%160,680美元 CO-LNV。 布兰德，佩顿12 25%95,790美元 系统 加里行政长官拉德拉奇125%71,028美元 程序员 耿海荣分析师12 100%53,250美元 程序员 (待定)技术12 100%50,000美元 GSRA 英语。GSRA(待定)12 100%23,422美元 SUBTOT0.1“”^ 顾问费 设备(分项) 在第2年和第3年购买 用品(按类别分项列出) 磁带机500美元 旅行 核心总监每年出差1-2次 住院病人护理费用 门诊病人 改建和翻新(按类别分列) 其他费用(按类别分项列出) GSRA学杂费14,772美元(秋季和冬季) 维护费3,000美元 联合体/合同成本 罗斯，布莱恩·D。 从头到尾 12/1/2006 11/30/2007 请求的美元金额(省略美分) 工资福利。 申请的福利总额 24,102元7,231元31,333元 23,948元7,184元31,132元 $3,551$1,065$4,616 $53,250$15,975$69,225 $50,000$15,000$65,000 $23,422$7,027$30,449 $178,273$53,482$231,755 i 500美元 1,200美元 17,772美元 直接成本 初步预算PEF的直接费用小计(项目7a，FacePage)$ 251,227 财团/合同成本|设施和管理成本！ 初始预算期间$I的直接费用总额 *251,227 仅限SBIR/STTR：需要收费 小灵通398(09/04版)页面表格第4页

Core C: Digital Image Processing The goals of the Digital Image Processing Core are to continue provide analytic tools for all projects. These unique image analysis tools are necessary for unbiased, accurate, quantitative analysis of temporal volumetric changes in single and multimodal MRI data sets of lab animals and human patients. Currently all MRI acquisitions independent of weightings for all interval exams of both animal and human studies are fully automatically registered to a "reference" data set in the first exam typically using a rotate- translate geometry model; this is a multimodality registration problem using existing software tools. Typically a T1-weighted, post-Gad sequence, is used as the reference for registering all successive interval exam sets. B1-field corrections have been found to be unnecessary thus far. In cases where the acquisitions involve high gradient fields such as those used for diffusion or perfusion weighted imaging, registrations are accomplished using a full affine model to support correction of shears caused by the gradients. Currently all human scan data including both original acquisitions and registered datasets, as well as animal backups, are stored on the Core's disk system. In the future all animal scans will be likewise stored on the Core's disks which can be accessed via TCP/IP or SAMBA protocols over 100 Mb ethernet. Of course the Core is responsible for maintaining data integrity and backup. The core will also develop the ability to track the positions of voxels within treated lesions across interval exams using high degree of freedom warpings. This facility for both animal and human imaging will support further investigation of the role of the apparent diffusion coefficient (ADC) as well as other parameters, e.g. perfusion, as potentially early indicators of therapeutic response. Additionally in the A1 amendment this Core demonstrated the ability to map histology back to in vivo MRI voxels for animals (where whole head ex vivo MRI acquisitions are possible) using only intrinsic scan information (i.e. no implanted fiducials of any kind). Pub. Health: Overall, this research effort willprovide therationale for initiation of clinical trials with combinations of molecularly targeted therapies for the treatment of malignant brain tumors. In addition, imaging biomarkers for early assessment of treatment response will be identified and validated which will lead to individualization of patient treatment. University of Michigan Ann Arbor, Michigan PHS 398(Rev. 09/04) Page 3/V Form Page 2 Principal Investigator/Program Director (Last, First, Middle): ROSS, Brian D. KEY PERSONNEL. See instructions. Usecontinuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Meyer, Charles Cmeyer University of Michigan Core Director Bland, Peyton University of Michigan Co-Investigator OTHER SIGNIFICANT CONTRIBUTORS Name Organization Role on Project Human Embryonic Stem Cells ^ No [~1 Yes If the proposed project involves human embryonic stem cells, list below the registration number of the specific cell llne(s) from the following list: http://stemcells.nih.gov/reaistrv/index.asp. Usecontinuationpages asneeded. If a specific line cannot be referenced at thistime, includea statement that one from the Registry will be used. Cell Line Disclosure Permission Statement Applicable toSBIR/STTR Onlv. See SBIR/STTR instructions. Q Yes Q No PHS 398 (Rev. 09/04) Page 31$" Form Page 2-continued Number the following pages consecutively throughout the application. Do not use suffixes such as 4a, 4b. Principal Investigator/Program Director (Last, first, middle): DETAILED BUDGET FOR INITIAL BUDGET PERIOD DIRECT COSTS ONLY Meyer/Core C PERSONNEL (Applicant organization only) % TYPE EFFORT INST. ROLE ON APPT. ON BASE NAME PROJECT (months) PROJ. SALARY Core Meyer, Charles Director 12 15% $160,680 Co-lnv. Bland, Peyton 12 25% $95,790 System Laderach, Gary Administrator 12 5% $71,028 Programmer Geng, Hairong Analyst 12 100% $53,250 Programmer (TBN) Technical 12 100% $50,000 GSRA Eng. GSRA (TBN) 12 100% $23,422 SUBTOT0.1 " "^ CONSULTANT COSTS EQUIPMENT (Itemize) Purchased in Years 2 & 3 SUPPLIES (Itemize bycategory) Mag Tape $500 TRAVEL 1 -2 Trips/year for Core Director PATIENT CARE COSTS INPATIENT OUTPATIENT ALTERATIONS AND RENOVATIONS (Itemize bycategory) OTHER EXPENSES (Itemize bycategory) GSRA Tuition & Fees $14,772 (Fall & Winter) Maintenance Fees $3,000 CONSORTIUM/CONTRACTUAL COSTS Ross, Brian D. FROM THROUGH 12/1/2006 11/30/2007 DOLLAR AMOUNT REQUESTED (omit cents) SALARY FRINGE . REQUESTED BENEFITS TOTALS $24,102 $7,231 $31,333 $23,948 $7,184 $31,132 $3,551 $1,065 $4,616 $53,250 $15,975 $69,225 $50,000 $15,000 $65,000 $23,422 $7,027 $30,449 $178,273 $53,482 $231,755 I $500 $1,200 $17,772 DIRECT COSTS SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PEF (Item 7a, FacePage) $ 251,227 CONSORTIUM/CONTRACTUAL COSTS | FACILITIES AND ADMINISTRATION COSTS! TOTAL DIRECTCOSTS FOR INITIAL BUDGET PERIOD $ I * 251 ,227 | SBIR/STTR Only: FEE REQUESTED PHS 398 (Rev. 09/04) Page Form Page 4