Digital Imaging Processing Core

数字图像处理核心

• 批准号: 7214539
• 负责人: Charles Raymond Meyer
• 金额: $ 30.89万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214539
• 关键词: Administrator; Amendment; Animals; Archives; Authorization documentation; Back; Biological Markers; Budgets; Cell Line; Cells; Clinical Trials; Data; Data Set; Data Storage and Retrieval; Databases; Development, Other; Diffusion; Direct Costs; Disclosure; Equipment; Fees; Freedom; Funding; Future; Goals; Head; Health; Histology; Human; Human Resources; Image; Image Analysis; Implant; Inpatients; Instruction; Investigation; Last Name; Lead; Lesion; Location; Magnetic Resonance Imaging; Maintenance; Malignant neoplasm of brain; Maps; Methods; Michigan; Modeling; Multimodal Imaging; Names; Noise; Numbers; Outpatients; Patient Care; Patients; Perfusion; Positioning Attribute; Principal Investigator; Protocols documentation; Publishing; Registries; Research; Research Personnel; Resolution; Role; Sampling; Scanning; Slice; Software Tools; Specific qualifier value; System; TAF8 gene; Techniques; Testing; Therapeutic; Translating; Travel; Universities; Wages; Weight; analytical tool; base; cost; data integrity; digital imaging; falls; human embryonic stem cell; human study; image processing; image registration; in vivo; method development; programs; response; size; tool; tumor

Core C: Digital Image Processing The goals of the Digital Image Processing Core are to continue provide analytic tools for all projects. These unique image analysis tools are necessary for unbiased, accurate, quantitative analysis of temporal volumetric changes in single and multimodal MRI data sets of lab animals and human patients. Currently all MRI acquisitions independent of weightings for all interval exams of both animal and human studies are fully automatically registered to a "reference" data set in the first exam typically using a rotate- translate geometry model; this is a multimodality registration problem using existing software tools. Typically a T1-weighted, post-Gad sequence, is used as the reference for registering all successive interval exam sets. B1-field corrections have been found to be unnecessary thus far. In cases where the acquisitions involve high gradient fields such as those used for diffusion or perfusion weighted imaging, registrations are accomplished using a full affine model to support correction of shears caused by the gradients. Currently all human scan data including both original acquisitions and registered datasets, as well as animal backups, are stored on the Core's disk system. In the future all animal scans will be likewise stored on the Core's disks which can be accessed via TCP/IP or SAMBA protocols over 100 Mb ethernet. Of course the Core is responsible for maintaining data integrity and backup. The core will also develop the ability to track the positions of voxels within treated lesions across interval exams using high degree of freedom warpings. This facility for both animal and human imaging will support further investigation of the role of the apparent diffusion coefficient (ADC) as well as other parameters, e.g. perfusion, as potentially early indicators of therapeutic response. Additionally in the A1 amendment this Core demonstrated the ability to map histology back to in vivo MRI voxels for animals (where whole head ex vivo MRI acquisitions are possible) using only intrinsic scan information (i.e. no implanted fiducials of any kind). Pub. Health: Overall, this research effort willprovide therationale for initiation of clinical trials with combinations of molecularly targeted therapies for the treatment of malignant brain tumors. In addition, imaging biomarkers for early assessment of treatment response will be identified and validated which will lead to individualization of patient treatment. University of Michigan Ann Arbor, Michigan PHS 398(Rev. 09/04) Page 3/V Form Page 2 Principal Investigator/Program Director (Last, First, Middle): ROSS, Brian D. KEY PERSONNEL. See instructions. Usecontinuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Meyer, Charles Cmeyer University of Michigan Core Director Bland, Peyton University of Michigan Co-Investigator OTHER SIGNIFICANT CONTRIBUTORS Name Organization Role on Project Human Embryonic Stem Cells ^ No [~1 Yes If the proposed project involves human embryonic stem cells, list below the registration number of the specific cell llne(s) from the following list: http://stemcells.nih.gov/reaistrv/index.asp. Usecontinuationpages asneeded. If a specific line cannot be referenced at thistime, includea statement that one from the Registry will be used. Cell Line Disclosure Permission Statement Applicable toSBIR/STTR Onlv. See SBIR/STTR instructions. Q Yes Q No PHS 398 (Rev. 09/04) Page 31$" Form Page 2-continued Number the following pages consecutively throughout the application. Do not use suffixes such as 4a, 4b. Principal Investigator/Program Director (Last, first, middle): DETAILED BUDGET FOR INITIAL BUDGET PERIOD DIRECT COSTS ONLY Meyer/Core C PERSONNEL (Applicant organization only) % TYPE EFFORT INST. ROLE ON APPT. ON BASE NAME PROJECT (months) PROJ. SALARY Core Meyer, Charles Director 12 15% $160,680 Co-lnv. Bland, Peyton 12 25% $95,790 System Laderach, Gary Administrator 12 5% $71,028 Programmer Geng, Hairong Analyst 12 100% $53,250 Programmer (TBN) Technical 12 100% $50,000 GSRA Eng. GSRA (TBN) 12 100% $23,422 SUBTOT0.1 " "^ CONSULTANT COSTS EQUIPMENT (Itemize) Purchased in Years 2 & 3 SUPPLIES (Itemize bycategory) Mag Tape $500 TRAVEL 1 -2 Trips/year for Core Director PATIENT CARE COSTS INPATIENT OUTPATIENT ALTERATIONS AND RENOVATIONS (Itemize bycategory) OTHER EXPENSES (Itemize bycategory) GSRA Tuition & Fees $14,772 (Fall & Winter) Maintenance Fees $3,000 CONSORTIUM/CONTRACTUAL COSTS Ross, Brian D. FROM THROUGH 12/1/2006 11/30/2007 DOLLAR AMOUNT REQUESTED (omit cents) SALARY FRINGE . REQUESTED BENEFITS TOTALS $24,102 $7,231 $31,333 $23,948 $7,184 $31,132 $3,551 $1,065 $4,616 $53,250 $15,975 $69,225 $50,000 $15,000 $65,000 $23,422 $7,027 $30,449 $178,273 $53,482 $231,755 I $500 $1,200 $17,772 DIRECT COSTS SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PEF (Item 7a, FacePage) $ 251,227 CONSORTIUM/CONTRACTUAL COSTS | FACILITIES AND ADMINISTRATION COSTS! TOTAL DIRECTCOSTS FOR INITIAL BUDGET PERIOD $ I * 251 ,227 | SBIR/STTR Only: FEE REQUESTED PHS 398 (Rev. 09/04) Page Form Page 4

核心C：数字图像处理 数字图像处理核心的目标是继续为所有项目提供分析工具。这些 独特的图像分析工具对于时间的公正、准确、定量分析是必要的 实验动物和人类患者的单模态和多模态 MRI 数据集的体积变化。 目前，所有 MRI 采集均独立于动物和人类所有间隔检查的权重 在第一次考试中，研究会完全自动注册到“参考”数据集，通常使用旋转 翻译几何模型；这是使用现有软件工具的多模态注册问题。通常 T1 加权后 Gad 序列用作注册所有连续间隔检查的参考 套。到目前为止，B1 场校正已被发现是不必要的。在收购的情况下 涉及高梯度场，例如用于扩散或灌注加权成像的场，配准是 使用完整的仿射模型来支持由梯度引起的剪切的校正。目前所有 人体扫描数据，包括原始采集数据和注册数据集，以及动物备份 存储在Core的磁盘系统上。将来所有动物扫描结果都将同样存储在 Core 的磁盘上 可以通过 100 Mb 以太网上的 TCP/IP 或 SAMBA 协议进行访问。当然核心是 负责维护数据完整性和备份。 该核心还将开发跨时间间隔跟踪治疗病变内体素位置的能力 使用高自由度扭曲的考试。该动物和人类成像设施将支持 进一步研究表观扩散系数 (ADC) 以及其他参数的作用，例如 灌注，作为治疗反应的潜在早期指标。此外，在 A1 修正案中， Core 展示了将组织学映射回动物体内 MRI 体素的能力（其中整个头部前 体内 MRI 采集是可能的）仅使用内在扫描信息（即没有植入任何的基准点） 种类）。 酒吧。健康：总体而言，这项研究工作将为启动临床试验提供理论依据 用于治疗恶性脑肿瘤的分子靶向疗法的组合。此外， 将识别和验证用于早期评估治疗反应的成像生物标志物，这将 从而实现患者治疗的个体化。 密歇根大学 密歇根州安娜堡 PHS 398(Rev. 09/04) 第 3 页/V 表格第 2 页 首席研究员/项目总监（最后、第一、中间）：ROSS, Brian D. 关键人员。请参阅说明。根据需要使用连续页面以如下所示的格式提供所需信息。 从首席研究员开始。按字母顺序列出所有其他关键人员，姓氏在前。 名称 eRA Commons 用户名 项目中的组织角色 Meyer, Charles Cmeyer 密歇根大学核心主任 布兰德，佩顿密歇根大学联合研究员 其他重要贡献者 名称 组织在项目中的角色 人类胚胎干细胞 ^ 否 [~1 是 如果拟议项目涉及人类胚胎干细胞，请在下面列出特定细胞系的注册号： http://stemcells.nih.gov/reaistrv/index.asp。根据需要使用续页。 如果此时无法引用特定行，请包含一条将使用注册表中的行的声明。 细胞系 披露许可声明适用于 SBIR/STTR Onlv。请参阅 SBIR/STTR 说明。问 是 Q 否 PHS 398（修订版 09/04）第 31 页 $" 表格第 2 页 - 续 对接下来的页码进行连续编号 该应用程序。请勿使用 4a、4b 等后缀。 首席研究员/项目主任（最后、第一个、中间）： 初始预算期的详细预算 仅直接成本 Meyer/Core C 人员（仅限申请组织）% 类型 努力 INST。 角色 PPT。基地 名称 项目（月） 项目。薪水 核 查尔斯·迈耶 董事 12 15% $160,680 联合投资。 佩顿·布兰德 12 25% $95,790 系统 加里·拉德拉赫 管理员 12 5% $71,028 程序员 耿海荣 分析师 12 100% $53,250 程序员 (TBN) 技术 12 100% $50,000 GSRA 工程师。 GSRA (TBN) 12 100% $23,422 SUBTOT0.1“”^ 顾问费用 设备（逐项列出） 第 2 年和第 3 年购买 用品（按类别逐项列出） 磁力胶带 500 美元 旅行 核心总监每年 1 -2 次出差 住院患者护理费用 门诊病人 改建和翻新（按类别分项） 其他费用（按类别分项） GSRA 学杂费 $14,772（秋季和冬季） 维护费 $3,000 财团/合同成本 罗斯，布莱恩·D. 从始至终 2006年12月1日 2007年11月30日 要求的美元金额（省略美分） 工资边缘。 要求的福利总计 $24,102 $7,231 $31,333 $23,948 $7,184 $31,132 $3,551 $1,065 $4,616 $53,250 $15,975 $69,225 $50,000 $15,000 $65,000 $23,422 $7,027 $30,449 $178,273 $53,482 $231,755 我 500 美元 1,200 美元 $17,772 直接成本 初始预算 PEF 直接成本小计（第 7a 项，FacePage） $ 251,227 财团/合同成本|设施和管理费用！ 初始预算期的直接成本总额 $ I * 251,227 | 仅限 SBIR/STTR：需要付费 PHS 398（修订版 09/04）页面表格第 4 页