AUTOMATIC 3D REGISTRATION FOR ENHANCED CANCER MANAGEMENT

自动 3D 配准以增强癌症管理

• 批准号: 6608879
• 负责人: Charles Raymond Meyer
• 金额: $ 154.75万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6608879
• 关键词: bioimaging /biomedical imaging; clinical research; image processing; imaging /visualization /scanning; method development; neoplasm /cancer diagnosis; neoplasm /cancer therapy; neoplastic growth; statistics /biometry

DESCRIPTION (provided by applicant) Driven by technology development, the oncologist/radiologist is currently under assault by increasing quantities of higher resolution anatomical and functional imaging data. The new LightSpeed CT scanner by GE is but one typical example of such new acquisition devices. It is imperative that new image processing tools be developed to help specialists filter through the massive amounts of data in order to maintain or even improve their sensitivity and specificity in detecting neoplastic changes. We believe that this grant is a significant step in this important direction and represents the best efforts of a truly multidisciplinary team. Automatic 3D Registration for Enhanced Cancer Management is a proposal to support limited, preclinical testing of the ability of advanced image processing techniques to improve the management of cancer by routinely culling more and earlier information for the clinician from existing diagnostic modalities. This program project grant includes a)the use of fMRI for pre (neuro)surgical planning focused on patients with movement disorders associated with lesions near the motor strip who could never remain sufficiently motionless for current fMRI techniques, b) support for lesion change detection and quantification from repeated, interval CT and ultrasound exams in order to monitor and potentially modify therapy plans based on individual patient response, c) automation in defining organs in radiation therapy treatment planning using noncontrast CT data sets, and d) the development of a method using registered CT and PET for reducing false positive nodes called on CT-only chest exams.

描述（由申请人提供） 在技​​术发展的推动下，肿瘤科医生/放射科医生目前正在 受到越来越多的更高分辨率的解剖学和 功能成像数据。 GE 的新型 LightSpeed CT 扫描仪只是其中之一 此类新型采集设备的典型例子。新的势在必行 开发图像处理工具来帮助专家筛选 大量数据以维持甚至提高其灵敏度 和检测肿瘤变化的特异性。我们相信这笔赠款 是朝着这个重要方向迈出的重要一步，代表了最好的 真正的多学科团队的努力。 自动 3D 配准以增强癌症管理是一项提议 支持高级图像能力的有限临床前测试 通过常规剔除改善癌症管理的加工技术 为临床医生提供更多、更早的现有诊断信息 方式。该计划项目拨款包括 a) 使用功能磁共振成像 (fMRI) 进行预 专注于运动障碍患者的（神经）手术计划 与运动带附近的病变有关，永远无法留下来 对于当前的功能磁共振成像技术来说足够静止，b) 对病变的支持 重复、间隔 CT 和超声的变化检测和量化 检查以监测并可能根据情况修改治疗计划 个体患者反应，c) 定义辐射器官的自动化 使用非对比 CT 数据集制定治疗计划，以及 d) 开发一种使用注册 CT 和 PET 来减少错误的方法 阳性淋巴结需要仅进行 CT 胸部检查。