课题基金 / 基金详情

An Autophagy^lnducing Peptide as a Novel Therapeutic for Intracellular NIAID Cla

An Autophagy^lnducing Peptide as a Novel Therapeutic for Intracellular NIAID Cla
自噬诱导肽作为细胞内 NIAID Cla 的新疗法
批准号:
8567979
负责人:
BETH C LEVINE
金额:
$45.88万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-03-01 至 2014-02-28

项目摘要

项目成果

BETH C LEVINE的其他基金

相关文献

中文摘要
翻译
细胞内病原体向溶酶体的自噬传递(在那里它们被破坏)正在出现
英文摘要
The autophagic delivery of intracellular pathogens to the lysosome (where they are destroyed) is emerging as a central mechanism of innate immunity; accordingly, the augmentation of host autophagy represents a potentially powerful new therapeutic approach to combat intracellular pathogens1-3. In our original project, we pursued four specific aims to develop an autophagy-inducing peptide that may be useful as a novel therapeutic in the treatment of diverse intracellular NIAID Class A, B, and C Priority pathogens. These aims included: 1. To confirm that the Tat-Beclin 1 peptide is a specific inducer of autophagy in vitro and in vivo. 2. To evaluate the mechanism by which the Tat-Beclin 1 induces autophagy. 3. To evaluate the effects of the Tat-Beclin 1 peptide on the in vitro growth of selected NIAID Category A, B, and C Priority Pathogens. 4. To evaluate the effects of the Tat-Beclin 1 peptide on microbial pathogenesis in mouse models of infection with selected NIAID Category A, B, and C Priority Pathogens. Thus far, we have completed the first aim and made significant progress towards completing Aims 2-4. To accelerate the development of a novel broad-spectrum antimicrobial biological product, the Tat-Beclin 1 autophagy-inducing peptide, we propose to work further on Aims 2-4 in parallel with investigations to determine the optimal dosing, immunogenicity, and preliminary safety profile of the peptide. These studies will help advance the development of a biologically active peptide (or small molecule compound that mimics its action) for the treatment of NIAID priority intracellular pathogens.
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Analysis of beclin 1 in autophagy and tumor suppression
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    7911042
  • 项目类别:
  • 资助金额:
    $13.78万
  • 财政年份:
    2009
  • 负责人:
    BETH C LEVINE
  • 依托单位:
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  • 批准号:
    8338320
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    $12.33万
  • 财政年份:
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  • 依托单位:
Infectious Diseases Training Program
  • 批准号:
    8663824
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2007
  • 负责人:
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  • 依托单位:
Infectious Diseases Training Program
  • 批准号:
    7496971
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2007
  • 负责人:
    BETH C LEVINE
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