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Biomaterials that Promote Infection Immunity

促进感染免疫的生物材料

基本信息

批准号：
8282948
负责人：
James D. Bryers
金额：
$ 51.28万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-07 至 2014-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8282948
关键词：
2-hydroxyethyl methacrylate Affect Air American Ammonium Anti-Infective Agents Antibiotic Therapy Antibiotics Antibodies Antibody Formation Antigen Presentation Antigen-Presenting Cells Antigens Artificial Heart Artificial cardiac pacemaker B-Cell Activation B-Lymphocytes Bacteria Bacterial Adhesins Binding Biocompatible Materials Biological Blood Vessel Prosthesis CD8B1 gene Cardiovascular system Catheters Cause of Death Cells Centers for Disease Control and Prevention (U.S.)Cerebrospinal fluid shunts procedure Cessation of life Chimeric Proteins Chlorhexidine Ciprofloxacin Code Communities Contact Lenses Control Groups Coupled Coupling Dendritic Cells Device Removal Devices Dose Drug Formulations Engineering Epitopes Escherichia coli Exhibits Exposure to FCGR3B gene Fibronectins Generic Drugs Genes Goals Growth Healed Health Heart Valve Prosthesis Hospitals Human Hydrogels Immune response Immunity Immunization Implant In Vitro Indwelling Catheter Infection Inflammatory Intrauterine Devices Invaded Left Liquid substance MHC Class I Genes MHC Class II Genes Mechanics Medical Medical Device Memory B-Lymphocyte Messenger RNA Methods Microbial Biofilms Modeling Monoclonal Antibodies Mus Nosocomial Infections Ocular Prosthesis Opsonin Organism Orthopedics Particulate Patients Performance Phagocytosis Pharmaceutical Preparations Polymers Prosthesis Recombinants Research Project Grants Residual state Series Silver Skin Staging Staphylococcus epidermidis Surface System T cell response T-Lymphocyte Therapeutic Time Transfection United States National Institutes of Health Vaccines Virulence Factors antimicrobial base controlled release cost design disorder prevention healing implantable device implantation in vivo killer T cell killings macrophage meetings microbial monocyte monomer novel particle poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer prevent protein complex receptor receptor binding response scaffold stressor success trafficking uptake urinary vector vector vaccine ventricular assist device

项目摘要

DESCRIPTION (provided by applicant): Nosocomial infections are the fourth leading cause of death in the U.S. with >2 million cases annually (or ~10% of American hospital patients). About 60% of these infections are associated with an implanted medical device causing >$4.5 billion medical costs in 1992 and ~80,000 deaths annually. It is estimated that over 5 million artificial or prosthetic parts are implanted per annum in the U.S. alone. Our goal, with NIH support, is to engineer biomaterials that will solicit a short- and long-term immune response to specific bacterial colonization. For short-term immediate defense, model biomaterials will release fusion protein complexes - artificial opsonins - designed to enhance the coupling of invading bacteria to monocyte/macrophage (MO); thus promoting phagocytosis. For long-term protection, the biomaterial will transfect antigen-presenting cells (specifically dendritic cells - DCs) to produce T- and B-cell memory and antibody expression, and potentially stimulate direct native killer T-cell responses. PUBLIC HEALTH RELEVANCE: It is estimated that over 5 million artificial or prosthetic devices are implanted per annum in the U.S. alone. However, 70% of hospital-acquired infections are associated with implants or indwelling medical devices, with the case-to-fatality ratio between 5-50%. In this 5-yr NIH RO1 research grant, we will develop a novel class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections.

描述（由申请人提供）：医院感染是美国第四大死亡原因，每年有> 200万例病例（或约10%的美国医院患者）。这些感染中约有60%与植入式医疗器械有关，1992年造成> 45亿美元的医疗费用，每年约有80，000人死亡。据估计，仅在美国每年就有超过500万个人工或假体部件被植入。在NIH的支持下，我们的目标是设计生物材料，以寻求对特定细菌定植的短期和长期免疫反应。对于短期即时防御，模型生物材料将释放融合蛋白复合物-人工调理素-旨在增强入侵细菌与单核细胞/巨噬细胞（MO）的偶联;从而促进吞噬作用。对于长期保护，生物材料将抑制抗原呈递细胞（特别是树突状细胞-DC）产生T细胞和B细胞记忆和抗体表达，并可能刺激直接的天然杀伤T细胞反应。公共卫生相关性：据估计，仅在美国每年就植入超过500万个人工或假体装置。然而，70%的医院获得性感染与植入物或留置医疗器械有关，病死率在5- 50%之间。在这项为期5年的NIH RO 1研究资助中，我们将开发一类新型生物材料，促进愈合，同时防止细菌定植和随后的感染。