2012 Fibroblast Growth Factors in Development & Disease Gordon Research Conferenc

描述（申请人提供）：本申请要求资金支持2012年（第四届）戈登研究会议（GRC）在Les Diablerets会议中心，Les Diablerets，瑞士，2012年5月13日至18日的发展与疾病中的成纤维细胞生长因子（FGF）和相关的（第一届）戈登研究研讨会（GRS）在FGF生物学中的新兴概念，5月12日至13日，2012年，在同一地点。 FGF包括生长和分化因子家族，其在组织和器官的发育、代谢和修复中具有重要功能。FGF信号传导的失调与人类疾病相关，包括几种发育/遗传疾病、代谢紊乱和恶性肿瘤。GF-GRC将邀请和摘要选定的演讲者进行演讲，以及扩展的海报会议，包括在这个高度多样化的领域的最新和最及时的研究。该会议将促进学术科学家，临床医生和来自研究FGF生物学各个方面的行业同事之间的跨学科互动。在这个独特的会议涵盖的主题包括FGF信号复合物的生物化学和下游信号通路的控制及其对细胞生物学，生理学，内分泌学，发育，药理学，病理学和再生/修复的影响。对于第一次，我们还将提供一个会前GRS，由初级研究人员在博士后水平为研究生，博士后和初级独立水平的研究人员组织，以介绍他们的研究在一个指导的环境，准备他们充分参与随后的GRC。 FGF-GRC & GRS组织者的目标是：1）提供一个国际论坛，用于讲座和海报，主要是未发表的数据，代表初级和高级FGF生物学家采取的各种方法。2)鼓励对数据进行广泛的正式和非正式讨论，为所有与会者提供新的和/或改进的实验方向。3)鼓励与会者之间的网络和新的合作，特别是那些在FGF生物学的不同领域和不同的进步水平。4)为初级研究人员提供FGF生物学和技术各个方面的最新背景，以及高级研究人员对其研究项目的建设性反馈。为了支持这些目标，我们建议：1）支持25名知名特邀演讲者/讨论领导人的差旅和/或注册费用，以及4名GRC和GRS组织者和4名初级独立调查员作为演讲者，2）支持2名知名特邀演讲者/导师的差旅和/或注册费用，1名初级独立调查员和10名研究生或博士后级别的受训人员参加GRS。 这些会议将通过介绍最新和重大进展以及各级科学家的多学科网络，为成纤维细胞生长因子领域做出重大贡献，增加将成纤维细胞生长因子生物学的新见解转化为广泛疾病的新型医学治疗方法的机会。 公共卫生相关性：我们要求资金部分支持2012年戈登研究会议（GRC）和戈登研究研讨会（GRS）的成纤维细胞生长因子（FGF）在发展和疾病。FGF是在组织和器官的发育、代谢和修复中具有基本功能的生长和分化因子，并且FGF信号传导的异常调节与人类疾病相关，包括几种发育/遗传病症、代谢紊乱和癌症。通过介绍和讨论最新的重要研究结果，以及各级科学家的多学科网络， 增加了将FGF生物学的新见解转化为广泛疾病的新型医学治疗的机会。

DESCRIPTION (provided by applicant): This application requests funds to support the 2012 (4th) Gordon Research Conference (GRC) on Fibroblast Growth Factors (FGFs) in Development & Disease at Les Diablerets Conference Center, Les Diablerets, Switzerland, May 13-18, 2012 and the associated (1st) Gordon Research Seminar (GRS) on Emerging Concepts in FGF Biology, May 12-13, 2012 at the same site. The FGFs comprise a family of growth and differentiation factors with essential functions in development, metabolism, and repair of tissues and organs. Dysregulation of FGF signaling is associated with human diseases, including several developmental/genetic diseases, metabolic disorders, and malignancies. The FGF- GRC will feature talks from invited and abstract-selected speakers as well as extended poster sessions encompassing the most recent and timely research in this highly diverse field. The conference will promote interdisciplinary interactions between academic scientists, clinicians and colleagues from industry studying all aspects of FGF biology. Topics covered in this unique conference include biochemistry of the FGF signaling complex and control of downstream signaling pathways and their impact on cell biology, physiology, endocrinology, development, pharmacology, pathology and regeneration/repair. For the first time, we will also offer a pre-conference GRS, organized by junior investigators at the postdoctoral level for investigators at the graduate student, postdoctoral and junior independent levels to present their research in a mentored environment, preparing them for full participation in the subsequent GRC. The goals of the FGF-GRC & GRS organizers are to: 1) Provide an international forum for talks and posters featuring mainly unpublished data representative of the diverse approaches taken by both junior and senior FGF biologists. 2) Encourage wide-ranging formal and informal discussions of the data, stimulating new and/or improved experimental directions for all attendees. 3) Encourage networking and new collaborations among attendees, particularly those in disparate fields of FGF biology and at different levels of advancement. 4) Provide junior investigators with an up-to-date background on all aspects of FGF biology and technology, and constructive feedback on their research projects from senior investigators. In support of these goals we propose to 1) support travel and/or registration costs for a diverse selection of 25 well-established invited speakers/discussion leaders plus the 4 GRC and GRS organizers and four junior independent investigators as speakers and 2) support travel and/or registration costs for 2 well-established invited speaker/mentors, 1 junior independent investigator and 10 trainees at the graduate student or postdoctoral levels to attend the GRS. These meetings will contribute significantly to the FGF field, through presentation of the most recent and significant advances and multidisciplinary networking of scientists at all levels, increasing opportunities for translaton of new insights into FGF biology into novel medical treatments for a broad range of diseases. PUBLIC HEALTH RELEVANCE: We request funds to partially support the 2012 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Fibroblast Growth Factors (FGFs) in Development & Disease. The FGFs are growth and differentiation factors with essential functions in development, metabolism and repair of tissues and organs and abnormal regulation of FGF signaling is associated with human diseases, including several developmental/genetic conditions, metabolic disorders and cancer. The FGF GRC and GRS will contribute significantly to advancing the FGF field, through presentation and discussion of the most recent and significant findings, and multidisciplinary networking of scientists at all levels, increasing opportunities for translation of new insights into FGF biology into novel medical treatments for a broad range of diseases.