2012 Fibroblast Growth Factors in Development & Disease Gordon Research Conferenc

描述(申请人提供)：本申请申请资助2012年5月13-18日在瑞士Les Diablerets会议中心举行的关于成纤维细胞生长因子(FGFs)在发育和疾病中的戈登研究会议(GRC)，以及2012年5月12-13日在同一地点举行的关于成纤维细胞生长因子(FGFs)生物学新概念的相关(第一次)Gordon研究研讨会(GRS)。FGFs由一系列生长和分化因子组成，在组织和器官的发育、新陈代谢和修复中具有重要功能。成纤维细胞生长因子信号的失调与人类疾病有关，包括几种发育/遗传疾病、代谢紊乱和恶性肿瘤。该论坛将邀请演讲者和经过抽象挑选的演讲者发表演讲，并举行延长的海报会议，介绍这一高度多样化领域的最新和最及时的研究成果。这次会议将促进学术科学家、临床医生和研究成纤维细胞生长因子生物学各个方面的业界同事之间的跨学科互动。这次独特的会议涵盖的主题包括成纤维细胞生长因子信号复合体的生物化学和下游信号通路的控制，以及它们对细胞生物学、生理学、内分泌学、发育、药理学、病理学和再生/修复的影响。我们还将首次提供由博士后初级研究人员组织的会前GRS，供研究生、博士后和初级独立水平的研究人员在指导环境中展示他们的研究，为他们全面参与随后的GRC做好准备。FGF-GRC和GRS组织者的目标是：1)为演讲和海报提供一个国际论坛，主要以未公布的数据为特色，代表初级和资深的FGF生物学家所采取的不同方法。2)鼓励对数据进行广泛的正式和非正式讨论，为所有与会者提供新的和/或改进的实验方向。3)鼓励与会者之间建立联系和开展新的合作，特别是那些在不同的成纤维细胞生长因子生物学领域和处于不同进步水平的人。4)向初级调查人员提供有关成纤维细胞生长因子生物学和技术各方面的最新背景，以及高级调查人员对其研究项目的建设性反馈。为支持这些目标，我们提议：1)支持由25位知名特邀演讲者/讨论领袖、4位GRC和GRS组织者以及4名初级独立调查人员作为演讲者的多样化遴选的差旅和/或注册费用；2)支持2名知名特邀演讲者/导师、1名初级独立调查员和10名研究生或博士后培训人员参加GRS的差旅和/或注册费用。这些会议将通过介绍最新的重大进展和各级科学家的多学科网络，增加将对成纤维细胞生长因子生物学的新见解转化为治疗各种疾病的新医疗方法的机会，从而对成纤维细胞生长因子领域作出重大贡献。 与公共健康相关：我们申请资金部分支持2012年戈登研究会议(GRC)和戈登研究研讨会(GRS)关于成纤维细胞生长因子(FGFs)在发育和疾病中的作用。成纤维细胞生长因子是生长和分化因子，在组织器官的发育、代谢和修复中具有重要作用，成纤维细胞生长因子信号的异常调节与多种人类疾病有关，包括多种发育/遗传疾病、代谢紊乱和癌症。基金会GRC和GRS将通过介绍和讨论最新和重要的发现以及各级科学家的多学科网络，为推进基金会领域做出重大贡献， 增加将对成纤维细胞生长因子生物学的新见解转化为针对广泛疾病的新医疗方法的机会。

DESCRIPTION (provided by applicant): This application requests funds to support the 2012 (4th) Gordon Research Conference (GRC) on Fibroblast Growth Factors (FGFs) in Development & Disease at Les Diablerets Conference Center, Les Diablerets, Switzerland, May 13-18, 2012 and the associated (1st) Gordon Research Seminar (GRS) on Emerging Concepts in FGF Biology, May 12-13, 2012 at the same site. The FGFs comprise a family of growth and differentiation factors with essential functions in development, metabolism, and repair of tissues and organs. Dysregulation of FGF signaling is associated with human diseases, including several developmental/genetic diseases, metabolic disorders, and malignancies. The FGF- GRC will feature talks from invited and abstract-selected speakers as well as extended poster sessions encompassing the most recent and timely research in this highly diverse field. The conference will promote interdisciplinary interactions between academic scientists, clinicians and colleagues from industry studying all aspects of FGF biology. Topics covered in this unique conference include biochemistry of the FGF signaling complex and control of downstream signaling pathways and their impact on cell biology, physiology, endocrinology, development, pharmacology, pathology and regeneration/repair. For the first time, we will also offer a pre-conference GRS, organized by junior investigators at the postdoctoral level for investigators at the graduate student, postdoctoral and junior independent levels to present their research in a mentored environment, preparing them for full participation in the subsequent GRC. The goals of the FGF-GRC & GRS organizers are to: 1) Provide an international forum for talks and posters featuring mainly unpublished data representative of the diverse approaches taken by both junior and senior FGF biologists. 2) Encourage wide-ranging formal and informal discussions of the data, stimulating new and/or improved experimental directions for all attendees. 3) Encourage networking and new collaborations among attendees, particularly those in disparate fields of FGF biology and at different levels of advancement. 4) Provide junior investigators with an up-to-date background on all aspects of FGF biology and technology, and constructive feedback on their research projects from senior investigators. In support of these goals we propose to 1) support travel and/or registration costs for a diverse selection of 25 well-established invited speakers/discussion leaders plus the 4 GRC and GRS organizers and four junior independent investigators as speakers and 2) support travel and/or registration costs for 2 well-established invited speaker/mentors, 1 junior independent investigator and 10 trainees at the graduate student or postdoctoral levels to attend the GRS. These meetings will contribute significantly to the FGF field, through presentation of the most recent and significant advances and multidisciplinary networking of scientists at all levels, increasing opportunities for translaton of new insights into FGF biology into novel medical treatments for a broad range of diseases. PUBLIC HEALTH RELEVANCE: We request funds to partially support the 2012 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Fibroblast Growth Factors (FGFs) in Development & Disease. The FGFs are growth and differentiation factors with essential functions in development, metabolism and repair of tissues and organs and abnormal regulation of FGF signaling is associated with human diseases, including several developmental/genetic conditions, metabolic disorders and cancer. The FGF GRC and GRS will contribute significantly to advancing the FGF field, through presentation and discussion of the most recent and significant findings, and multidisciplinary networking of scientists at all levels, increasing opportunities for translation of new insights into FGF biology into novel medical treatments for a broad range of diseases.