2012 Fibroblast Growth Factors in Development & Disease Gordon Research Conferenc

描述（由申请人提供）：本申请申请资金用于支持2012年5月13日至18日在瑞士Les diableets会议中心举行的2012（第四届）关于成纤维细胞生长因子（FGFs）在发育和疾病中的戈登研究会议（GRC），以及2012年5月12日至13日在同一地点举行的相关（第一届）关于FGF生物学新兴概念的戈登研究研讨会（GRS）。FGFs包括一系列生长和分化因子，在组织和器官的发育、代谢和修复中具有重要功能。FGF信号的失调与人类疾病有关，包括几种发育/遗传疾病、代谢紊乱和恶性肿瘤。FGF- GRC将有特邀和精选演讲者的演讲，以及扩展的海报会议，涵盖这个高度多样化领域的最新和及时的研究。会议将促进学术科学家、临床医生和工业界研究FGF生物学各个方面的同事之间的跨学科互动。本次会议的主题包括FGF信号复合体的生物化学和下游信号通路的控制及其对细胞生物学、生理学、内分泌学、发育学、药理学、病理学和再生/修复的影响。我们还将首次提供会前GRS，由博士后水平的初级研究人员组织，供研究生，博士后和初级独立水平的研究人员在指导环境中展示他们的研究，为他们充分参与随后的GRC做好准备。FGF- grc和GRS组织者的目标是：1)提供一个国际论坛，主要介绍初级和高级FGF生物学家采用的不同方法的未发表数据。2)鼓励对数据进行广泛的正式和非正式讨论，为所有与会者激发新的和/或改进的实验方向。3)鼓励与会者之间的交流和新的合作，特别是在FGF生物学不同领域和不同发展水平的参与者。4)为初级研究人员提供FGF生物学和技术各方面的最新背景知识，并从高级研究人员那里获得对其研究项目的建设性反馈。为了支持这些目标，我们建议：1)支持25位知名的特邀演讲者/讨论领导者以及4位GRC和GRS组织者和4位初级独立调查员作为演讲者的差旅费和/或注册费；2)支持2位知名的特邀演讲者/导师、1位初级独立调查员和10位研究生或博士后级别的学员参加GRS的差旅费和/或注册费。这些会议将对FGF领域做出重大贡献，通过展示最新和重要的进展，以及各级科学家的多学科网络，增加了将FGF生物学的新见解转化为广泛疾病的新医学治疗的机会。

DESCRIPTION (provided by applicant): This application requests funds to support the 2012 (4th) Gordon Research Conference (GRC) on Fibroblast Growth Factors (FGFs) in Development & Disease at Les Diablerets Conference Center, Les Diablerets, Switzerland, May 13-18, 2012 and the associated (1st) Gordon Research Seminar (GRS) on Emerging Concepts in FGF Biology, May 12-13, 2012 at the same site. The FGFs comprise a family of growth and differentiation factors with essential functions in development, metabolism, and repair of tissues and organs. Dysregulation of FGF signaling is associated with human diseases, including several developmental/genetic diseases, metabolic disorders, and malignancies. The FGF- GRC will feature talks from invited and abstract-selected speakers as well as extended poster sessions encompassing the most recent and timely research in this highly diverse field. The conference will promote interdisciplinary interactions between academic scientists, clinicians and colleagues from industry studying all aspects of FGF biology. Topics covered in this unique conference include biochemistry of the FGF signaling complex and control of downstream signaling pathways and their impact on cell biology, physiology, endocrinology, development, pharmacology, pathology and regeneration/repair. For the first time, we will also offer a pre-conference GRS, organized by junior investigators at the postdoctoral level for investigators at the graduate student, postdoctoral and junior independent levels to present their research in a mentored environment, preparing them for full participation in the subsequent GRC. The goals of the FGF-GRC & GRS organizers are to: 1) Provide an international forum for talks and posters featuring mainly unpublished data representative of the diverse approaches taken by both junior and senior FGF biologists. 2) Encourage wide-ranging formal and informal discussions of the data, stimulating new and/or improved experimental directions for all attendees. 3) Encourage networking and new collaborations among attendees, particularly those in disparate fields of FGF biology and at different levels of advancement. 4) Provide junior investigators with an up-to-date background on all aspects of FGF biology and technology, and constructive feedback on their research projects from senior investigators. In support of these goals we propose to 1) support travel and/or registration costs for a diverse selection of 25 well-established invited speakers/discussion leaders plus the 4 GRC and GRS organizers and four junior independent investigators as speakers and 2) support travel and/or registration costs for 2 well-established invited speaker/mentors, 1 junior independent investigator and 10 trainees at the graduate student or postdoctoral levels to attend the GRS. These meetings will contribute significantly to the FGF field, through presentation of the most recent and significant advances and multidisciplinary networking of scientists at all levels, increasing opportunities for translaton of new insights into FGF biology into novel medical treatments for a broad range of diseases. PUBLIC HEALTH RELEVANCE: We request funds to partially support the 2012 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Fibroblast Growth Factors (FGFs) in Development & Disease. The FGFs are growth and differentiation factors with essential functions in development, metabolism and repair of tissues and organs and abnormal regulation of FGF signaling is associated with human diseases, including several developmental/genetic conditions, metabolic disorders and cancer. The FGF GRC and GRS will contribute significantly to advancing the FGF field, through presentation and discussion of the most recent and significant findings, and multidisciplinary networking of scientists at all levels, increasing opportunities for translation of new insights into FGF biology into novel medical treatments for a broad range of diseases.