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Project 2: Endocrine Disruptors, Epigenetic Mechanims and Neurodevelopment

项目2：内分泌干扰物、表观遗传机制和神经发育

基本信息

批准号：
8322717
负责人：
Virginia A Rauh
金额：
$ 19.4万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8322717
关键词：
10 year old 11 year old Accounting Affect Age Air Pollutants Animals Anxiety Anxiety Disorders Area Aromatic Polycyclic Hydrocarbons Attention Behavior Behavior Disorders Behavioral Biological Biological Markers Brain Brain Chemistry Brain region Candidate Disease Gene Child Child Behavior Child Development Child health care Clinical Clinical assessments Cognitive Cognitive deficits Cohort Studies Collaborations Communities DNA Methylation Data Databases Development Diagnosis Diagnostic Diagnostic tests Diffusion Magnetic Resonance Imaging Disease Education Emotional Endocrine Endocrine Disruptors Endocrine disruption Environment Environmental Exposure Environmental Health Environmental Tobacco Smoke Epigenetic Process Ethnic Origin Etiology Exposure to Fetal Growth France Funding Gene Expression Genes Grant Health Heavy Metals Housing Immune Impairment Impulsive Behavior Impulsivity Individual Inflammatory Informal Social Control Intelligence Intervention Investigation Learning Learning Disorders Leukocytes Link Literature Long-Term Effects Low income Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measures Mediating Mediator of activation protein Memory Mental Depression Metabolism Methods Methylation Minority Modeling Modification Monitor Mood Disorders Morphology Mus National Institute of Environmental Health Sciences Nature Neighborhoods Neurodevelopmental Disorder Neuropsychological Tests Neurotoxins New York City Outcome Pathway interactions Patient Self-Report Pattern Performance Perinatal Exposure Policies Poverty Prevention Primary Schools Problem behavior Process Psychopathology Puberty Reporting Research Risk Risk Factors Role Sampling Schools Secondary to Siblings Structure Symptoms Target Populations Testing Time Toxic effect Toxicant exposure Umbilical Cord Blood Umbilical cord structure adverse outcome air monitoring base bisphenol A brain tissue case control cognitive function cohort cost effective depressive symptoms design developmental disease early adolescence environmental chemical executive function experience fetal follow-up genome-wide high school innovation middle school neurobehavioral neurobehavioral disorder neurodevelopment neurotoxic novel peripheral blood postnatal prenatal prenatal exposure prevent prospective psychologic relating to nervous system research clinical testing research study sex social social skills stressor toxicant trafficking

项目摘要

17% of U.S. children have been diagnosed with a learning or behavior disorder. We are proposing policy relevant research on the contribution of prenatal exposures to the common endocrine disruptors, polycyclic aromatic hydrocarbons (PAH) and bisphenol A (BPA), to neurodevelopmental disorders in early adolescence, and epigenetic mechanisms as mediators of these effects. The project takes advantage of our ongoing cohort study of children residing in low-income, minority neighborhoods of New York City who have been followed by the Columbia Center for Children's Environmental Health (CCCEH) since 1998 and of our new study of younger siblings (Sibling/Hermanos cohort). Our cohorts provide a unique opportunity to evaluate the longer-term consequences of prenatal exposure to PAH and, for the first time, to assess the effect of prenatal BPA exposure through the peri-pubertal years, elucidating the role of epigenetic mechanisms in their neurobehavioral impacts. Aim1: Determine whether prenatal exposures to the endocrine disruptors PAH and BPA are associated with adverse neurobehavioral outcomes in peri-pubertal children, as measured by diagnostic assessment of child psychopathology and cognitive functioning. Aim 2: Determine whether prenatal exposure to PAH or BPA is associated with epigenetic changes in umbilical cord white blood cells (DNA methylation validated by gene expression) in candidate genes/pathways associated with endocrine disruption and immune dysregulation known to be critical in fetal brain development, and whether altered methylation and gene expression is associated with the neurobehavioral outcomes described in Aim 1. Aim 3: Using GIS, determine the extent to which neighborhood-level conditions contribute to neurobehavioral outcomes and/or moderate the individual-level associations between exposure to PAH or BPA and child neurodevelopment (as seen in Aims 1 and 2). Understanding of the multi-factorial etiology and mechanisms of developmental disorders that affect children's academic performance will open new avenues for prevention.

17%的美国儿童被诊断患有学习或行为障碍。我们正在提出相关政策建议