INTERGRATIVE HEALTH SCIENCES CORE

综合健康科学核心

• 批准号: 8279269
• 负责人: Edward Avol
• 金额: $ 63.53万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8279269
• 关键词: Air Pollution; Biometry; Carotid Arteries; Cells; Characteristics; Child; Cohort Studies; Collection; Communities; Community Relations; Computers; Core Facility; Data; Data Collection; Documentation; Enrollment; Equilibrium; Exhalation; Feedback; Genes; Genetic; Genetic Materials; Health; Health Sciences; Health Status; Human Resources; Individual; Informed Consent; Interview; Legal Guardians; Location; Logistics; Maintenance; Measurement; Molecular Biology; Nature; Nitric Oxide; Parents; Performance; Population; Population Study; Pulmonary function tests; Quality Control; Questionnaires; Research; Research Personnel; Research Project Grants; Resources; Sampling; Schools; Self-Administered; Specimen; Spirometry; Study Subject; Symptoms; System; Testing; Thick; Training; Update; Work; Writing; base; cohort; computerized; data management; improved; operation; programs; quality assurance; respiratory; volunteer; young adult

The Integrative Health Sciences Core (IHSC) is central to the successful completion of the program of research proposed in this renewal. IHSC activities expand the previous scope of work of the Field Operations Core in the original P01 by maximizing project coordination and efficiency. This will be accomplished by centralizing all aspects of school and community relations, subject contact, health data collections and cohort maintenance. The complementary nature of the proposed projects and the synergy achieved from utilizing the same volunteer subject population and community air pollution sampling locations for all three projects provide a common basis for consolidation of complementary field support efforts. The integrative coordination provided by the IHSC will reduce the need for repetitive subject contacts required to accomplish the aims of the three projects in the renewal P01, establish a unified and efficient updating system for subject tracking and facilitate streamlined and coordinated interactions with study subjects, all of which are required for successful cohort studies. Subject recruitment for various programmatic sub-studies will be overseen by the IHSC to balance scientific requirements and research needs with subject access and necessary research documentation. The IHSC will collect health information needed in the study projects (including individual personal computerized interview, maximal exhaled spirometry, self-administered questionnaires and additional genetic material for gene/environmental array analyses). The IHSC will coordinate efforts with complementary data collection activities being performed on the same study subjects for other ongoing projects, such as the off-line or realtime collection of exhaled nitric oxide and the non-invasive measurement of carotid artery thickness. This will permit timely subject interactions, make better use of limited field staff and reduce subject and school inconveniences. The core will also facilitate coordinated interactions with the Biostatistics and Data Management Core in managing data and providing prompt feedback on study performance and quality assurance activities. Additionally, the IHSC will provide a centralized contact point for each of the projects and facility cores such as the Molecular Biology Core in the SCEHSC. Finally, a centralized approach to providing for project data collection under the oversight of a single core led by one investigator with over-arching coverage of, commitments to and relationships with each of the projects will improve overall P01 efficiency.

综合健康科学核心（IHSC）是成功完成该计划的核心。 在这次更新中提出的研究。国际人道主义事务协调委员会的活动扩大了外地业务以前的工作范围 在原有的P01核心通过最大限度地提高项目协调和效率。这将通过 集中学校和社区关系、学科联系、健康数据收集和队列的所有方面 上维护拟议项目的互补性质以及利用 所有三个项目的志愿受试者人数和社区空气污染采样地点相同， 巩固补充性外勤支助工作的共同基础。综合协调 IHSC提供的信息将减少为实现目标所需的重复受试者接触的需要， 更新P01中的三个项目，建立统一、高效的更新系统进行受试者跟踪， 促进与研究受试者的简化和协调的互动，所有这些都是成功的必要条件。 队列研究 各种项目子研究的受试者招募将由IHSC监督，以平衡科学 要求和研究需要，并提供受试者访问和必要的研究文件。IHSC将 收集研究项目所需的健康信息（包括个人电脑访谈， 最大呼出肺量测定，自我管理的问卷调查和额外的遗传物质， 基因/环境阵列分析）。IHSC将与补充数据收集工作协调 正在进行的其他项目，如离线或实时的相同的研究对象的活动 收集呼出的一氧化氮和颈动脉厚度的非侵入性测量。这将 允许及时的学科互动，更好地利用有限的现场工作人员，减少学科和学校 不便之处该核心还将促进与生物统计和数据中心的协调互动。 管理数据并提供研究绩效和质量的及时反馈 保证活动。此外，IHSC将为每个项目提供一个中央联络点， 设施核心，如SCEHSC中的分子生物学核心。最后，提供集中式方法 在由一名调查员领导的单一核心监督下进行项目数据收集， 每个项目的覆盖范围、承诺和与每个项目的关系将提高P01的总体效率。