INTERGRATIVE HEALTH SCIENCES CORE

综合健康科学核心

• 批准号: 7628992
• 负责人: Edward Avol
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7628992
• 关键词: Air Pollution; Biometry; Carotid Arteries; Cells; Characteristics; Cohort Studies; Collection; Communities; Community Relations; Computers; Core Facility; Data; Data Collection; Documentation; Enrollment; Equilibrium; Exhalation; Feedback; Genes; Genetic Materials; Health; Health Sciences; Health Status; Human Resources; Individual; Informed Consent; Interview; Invasive; Legal Guardians; Location; Logistics; Maintenance; Measurement; Molecular Biology; Nature; Nitric Oxide; Operative Surgical Procedures; Parents; Performance; Population; Population Study; Pulmonary function tests; Quality Control; Questionnaires; Research; Research Personnel; Research Project Grants; Resources; Sampling; Schools; Self-Administered; Specimen; Spirometry; Study Subject; Symptoms; System; Testing; Thick; Training; Update; Work; Writing; base; cohort; computerized; data management; improved; programs; quality assurance; volunteer

The Integrative Health Sciences Core (IHSC) is central to the successful completion of the program of research proposed in this renewal. IHSC activities expand the previous scope of work of the Field Operations Core in the original P01 by maximizing project coordination and efficiency. This will be accomplished by centralizing all aspects of school and community relations, subject contact, health data collections and cohort maintenance. The complementary nature of the proposed projects and the synergy achieved from utilizing the same volunteer subject population and community air pollution sampling locations for all three projects provide a common basis for consolidation of complementary field support efforts. The integrative coordination provided by the IHSC will reduce the need for repetitive subject contacts required to accomplish the aims of the three projects in the renewal P01, establish a unified and efficient updating system for subject tracking and facilitate streamlined and coordinated interactions with study subjects, all of which are required for successful cohort studies. Subject recruitment for various programmatic sub-studies will be overseen by the IHSC to balance scientific requirements and research needs with subject access and necessary research documentation. The IHSC will collect health information needed in the study projects (including individual personal computerized interview, maximal exhaled spirometry, self-administered questionnaires and additional genetic material for gene/environmental array analyses). The IHSC will coordinate efforts with complementary data collection activities being performed on the same study subjects for other ongoing projects, such as the off-line or realtime collection of exhaled nitric oxide and the non-invasive measurement of carotid artery thickness. This will permit timely subject interactions, make better use of limited field staff and reduce subject and school inconveniences. The core will also facilitate coordinated interactions with the Biostatistics and Data Management Core in managing data and providing prompt feedback on study performance and quality assurance activities. Additionally, the IHSC will provide a centralized contact point for each of the projects and facility cores such as the Molecular Biology Core in the SCEHSC. Finally, a centralized approach to providing for project data collection under the oversight of a single core led by one investigator with over-arching coverage of, commitments to and relationships with each of the projects will improve overall P01 efficiency.

综合健康科学核心（IHSC）是成功完成该计划的核心 本次更新中提出的研究。 IHSC 活动扩大了现场行动之前的工作范围 原始 P01 的核心是通过最大化项目协调和效率。这将通过以下方式完成 集中学校和社区关系、受试者接触、健康数据收集和队列的各个方面 维护。拟议项目的互补性以及利用这些项目所实现的协同效应 所有三个项目的相同志愿者受试者群体和社区空气污染采样点提供 巩固互补性外勤支助工作的共同基础。综合协调 IHSC 提供的服务将减少实现目标所需的重复受试者接触的需要 更新P01中的三个项目，建立统一高效的更新系统，用于主题跟踪和更新 促进与研究对象的简化和协调的互动，所有这些都是成功所必需的 队列研究。 各种计划子研究的受试者招募将由 IHSC 监督，以平衡科学性 要求和研究需求以及主题访问和必要的研究文件。 IHSC 将 收集研究项目所需的健康信息（包括个人电脑访谈、 最大呼气肺活量测定、自填问卷和额外遗传材料 基因/环境阵列分析）。 IHSC 将协调补充数据收集工作 其他正在进行的项目在同一研究主题上进行的活动，例如离线或实时 收集呼出的一氧化氮并无创测量颈动脉厚度。这将 允许及时的学科互动，更好地利用有限的现场工作人员并减少学科和学校 不便之处。该核心还将促进与生物统计和数据的协调互动 管理核心管理数据并提供有关研究表现和质量的及时反馈 保证活动。此外，IHSC 将为每个项目提供一个集中的联络点， 设施核心，例如 SCEHSC 的分子生物学核心。最后，一种集中的方法来提供 在一名调查员领导的单一核心的监督下收集项目数据 每个项目的覆盖范围、承诺以及与每个项目的关系将提高总体 P01 效率。