Neuroscience Imaging Center at OHSU

我们建议在俄亥俄州立大学建立一个神经科学成像中心， 电子，荧光和共聚焦显微镜的仪器以及设计和 分析成像实验。神经科学成像中心将有3个核心：1）活细胞成像 核心，2）共焦核心，和3）EM核心。所需的主要仪器和专业知识， 建立这些核心已经存在于OHSU。然而，由于缺乏足够的核心人员， 显微镜阻碍了NINDS研究人员有效和可靠地使用这些仪器。的 神经科学成像中心将为这些显微镜提供专门的工作人员，以增强和 促进OHSU的NINDS调查人员的研究。一个咨询委员会，由一个行政机构协助， 核心，将监督中心的运作，审查和优化该组成部分的有效性 核心，并管理该中心的财务方面。这三个核心将共同发挥作用， 从实验设计到性能，再到数据分析的综合设施。仪器资源 将位于西部和马奎姆山校区，从而为整个OHSU服务 神经科学社区Sue Aicher博士和加里班克博士将担任该中心的联合主任; 董事带来了独特的科学和技术资格和管理共享设施的经验。 中心主任将提供前端咨询与研究人员，完善实验 问题和制定个人实验的最佳技术方法。三大核心管理者 和技术人员将操作主要仪器，培训新用户，并提供全面服务 一些研究人员的实验。将为主要研究者提供培训机会， 博士后和研究生。神经科学是OHSU研究的核心， 成像中心将为23个NINDS资助的研究项目带来尖端的成像技术， 以及我们的NINDS资助的学员。神经科学成像中心将催化专注于 我们整个神经科学界的互动。

We propose to establish a Neuroscience Imaging Center at OHSU that will provide state-of-the-art instrumentation for electron, fluorescent, and confocal microscopy as well as expertise in designing and analyzing imaging experiments. The Neuroscience Imaging Center will have 3 cores: 1) a Live-cell Imaging Core, 2) a Confocal Core, and 3) an EM Core. The major instrumentation and expertise necessary for establishing these cores exist already at OHSU. However, the lack of fully staffed cores for these microscopes prevents efficient and reliable use of these instruments by NINDS investigators. The Neuroscience Imaging Center will provide the dedicated staff for these microscopes to enhance and facilitate the research by NINDS investigators at OHSU. An advisory committee, aided by an administrative core, will oversee the operations of the Center, review and optimize the effectiveness of the component cores, and manage the fiscal aspects of the Center. The three cores will function together as a truly integrated facility from experimental design, to performance, to data analysis. Instrumentation resources will be located on both the West and Marquam Hill campuses, thereby serving the entire OHSU neuroscience community. Drs. Sue Aicher and Gary Banker will serve as co-Directors of the Center; each Director brings unique scientific and technical qualifications and experience in managing shared facilities. The Center Directors will provide front-end consultation with the investigators, refining experimental questions and fomnulating optimal technical approaches for individual experiments. Three Core Managers and technical staff will operate the major instrumentation, train new users, and provide full service experiments for some investigators. Training opportunities will be available to serve principal investigators, postdoctoral fellows, and graduate students. Neuroscience is the centerpiece of research at OHSU, the Imaging Center will bring cutting-edge imaging to the 23 NINDS-funded research programs identified in this proposal, as well as our NINDS-funded trainees. The Neuroscience Imaging Center will catalyze focused interactions within our entire neuroscience community.