Neuroscience Imaging Center at OHSU

OHSU 神经科学影像中心

• 批准号: 8085692
• 负责人: THOMAS J KELLER
• 金额: $ 29.43万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8085692
• 关键词: Address; Advisory Committees; Arts; Cells; Collaborations; Communities; Confocal Microscopy; Consultations; Coupled; Data Analyses; Effectiveness; Electron Microscope; Electron Microscopy; Electrons; Electrophysiology (science); Equipment; Experimental Designs; Faculty; Funding; Grant; Health Sciences; Housing; Image; Image Analysis; Imaging technology; Individual; Institutes; Lasers; Learning; Life; Measurement; Mentors; Methods; Microscope; National Institute of Neurological Disorders and Stroke; Neurosciences; Oregon; Performance; Postdoctoral Fellow; Primates; Principal Investigator; Research; Research Personnel; Research Project Grants; Resources; Running; Services; Site; Structure; System; Technical Expertise; Training; Training Support; United States National Institutes of Health; Universities; University Hospitals; base; cellular imaging; data acquisition; design; digital; experience; graduate student; immunocytochemistry; instrument; instrumentation; light microscopy; meetings; microbial alkaline proteinase inhibitor; operation; post-doctoral training; pre-doctoral; prevent; programs; research study; technology development; theories; two-photon

We propose to establish a Neuroscience Imaging Center at OHSU that will provide state-of-the-art instrumentation for electron, fluorescent, and confocal microscopy as well as expertise in designing and analyzing imaging experiments. The Neuroscience Imaging Center will have 3 cores: 1) a Live-cell Imaging Core, 2) a Confocal Core, and 3) an EM Core. The major instrumentation and expertise necessary for establishing these cores exist already at OHSU. However, the lack of fully staffed cores for these microscopes prevents efficient and reliable use of these instruments by NINDS investigators. The Neuroscience Imaging Center will provide the dedicated staff for these microscopes to enhance and facilitate the research by NINDS investigators at OHSU. An advisory committee, aided by an administrative core, will oversee the operations of the Center, review and optimize the effectiveness of the component cores, and manage the fiscal aspects of the Center. The three cores will function together as a truly integrated facility from experimental design, to performance, to data analysis. Instrumentation resources will be located on both the West and Marquam Hill campuses, thereby serving the entire OHSU neuroscience community. Drs. Sue Aicher and Gary Banker will serve as co-Directors of the Center; each Director brings unique scientific and technical qualifications and experience in managing shared facilities. The Center Directors will provide front-end consultation with the investigators, refining experimental questions and fomnulating optimal technical approaches for individual experiments. Three Core Managers and technical staff will operate the major instrumentation, train new users, and provide full service experiments for some investigators. Training opportunities will be available to serve principal investigators, postdoctoral fellows, and graduate students. Neuroscience is the centerpiece of research at OHSU, the Imaging Center will bring cutting-edge imaging to the 23 NINDS-funded research programs identified in this proposal, as well as our NINDS-funded trainees. The Neuroscience Imaging Center will catalyze focused interactions within our entire neuroscience community.

我们建议在俄亥俄州立大学建立一个神经科学成像中心，它将提供最先进的 电子、荧光和共聚焦显微镜的仪器，以及设计和 分析成像实验。神经科学成像中心将有三个核心：1)活细胞成像 核心，2)共焦核心，以及3)EM核心。所需的主要仪器设备和专业知识 OHSU已经建立了这些核心。然而，这些核心缺乏完整的人员配备 显微镜阻止NINDS调查人员有效和可靠地使用这些仪器。这个 神经科学成像中心将为这些显微镜提供专门的工作人员，以增强和 促进OHSU NINDS调查人员的研究。一个咨询委员会，由一名行政官员协助 核心，将监督中心的运作，审查和优化该组成部分的有效性 核心，并管理中心的财务方面。这三个核心将作为一个真正的 从实验设计到性能，再到数据分析的综合设施。仪器资源 将同时位于西区和Marquam Hill校区，从而为整个OHSU提供服务 神经科学界。Sue Aicher博士和Gary Banker博士将分别担任该中心的联席主任； 总监带来了管理共享设施的独特科技资质和经验。 中心主任将与调查人员提供前端咨询，细化实验 提出问题，为个别实验找出最佳的技术方法。三位核心经理 和技术人员将操作主要仪器，培训新用户，并提供全面服务 一些调查人员的实验。将提供培训机会，为主要调查人员服务， 博士后研究员和研究生。神经科学是OHSU研究的核心， 影像中心将为NINDS资助的23个研究项目带来尖端成像 提案，以及我们NINDS资助的实习生。神经科学成像中心将催化聚焦 我们整个神经科学界的相互作用。