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Structural studies of Ebola VP35 mediated immune evasion mechanisms

埃博拉VP35介导的免疫逃避机制的结构研究

基本信息

批准号：
8368083
负责人：
Gaya K. Amarasinghe
金额：
$ 24.32万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8368083
关键词：
Antiviral Agents Attention Attenuated Beryllium Binding Biochemical Biological Bioterrorism C-terminal Categories Cells Collaborations Complement Complex Coupled Data Disease Outbreaks Double-Stranded RNA Double-Stranded RNA Binding Domain Ebola virus Elements Genes Genetic Transcription Genome Goals Growth Health Human Immune Immune response Immune system Immunosuppression In Vitro Indium Infection Interferon Activation Interferons Knowledge Laboratories Lead Length Mediating Methods Modeling Molecular Mutation N-terminal Natural Immunity Nature Pathogenesis Pathogenicity Polymerase Population Production Property Proteins RNA RNA Binding Reagent Recombinants Reporting Research Resources Role Signal Transduction Staging Stress Structure Surface Testing Therapeutic Intervention Translations Vaccines Viral Viral Hemorrhagic Fevers Viral Packaging Viral Pathogenesis Viral Proteins Virulence Virulence Factors Virus Diseases Work base cofactor combat design eIF-2 Kinase human IRF3 protein improved in vivo innovation insight interferon regulatory factor-3 loss of function medical schools multidisciplinary mutant novel diagnostics novel strategies novel therapeutics pathogen programs research study response therapy design vaccine development viral RNA

项目摘要

项目成果

期刊论文数量（0）

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科研奖励数量（0）

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专利数量（0）

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Gaya K. Amarasinghe其他文献

Disruption of Ebola NPsup0/supVP35 Inclusion Body-like Structures reduce Viral Infection

破坏埃博拉病毒核蛋白（N）VP35 包涵体样结构可降低病毒感染

DOI：
10.1016/j.jmb.2023.168241
发表时间：
2023-10-15
期刊：
JOURNAL OF MOLECULAR BIOLOGY
影响因子：
4.500
作者：
Chao Wu;Nicole D. Wagner;Austin B. Moyle;Annie Feng;Nitin Sharma;Sarah H. Stubbs;Callie Donahue;Robert A. Davey;Michael L. Gross;Daisy W. Leung;Gaya K. Amarasinghe
通讯作者：
Gaya K. Amarasinghe

Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25

人类呼吸道合胞病毒转录调节因子 NS1 与 MED25 相互作用的分子基础

DOI：
10.1038/s41467-025-58216-4
发表时间：
2025-03-25
期刊：
Nature Communications
影响因子：
15.700
作者：
Parismita Kalita;Oam Khatavkar;Grace Uwase;Yulia Korshunova;Yuying Hu;Nicole D. Wagner;Jian Xu;Jiehong Pan;Jay C. Nix;Michael L. Gross;Steven L. Brody;Dominika Borek;Gaya K. Amarasinghe;Jacqueline E. Payton;Daisy W. Leung
通讯作者：
Daisy W. Leung

Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein

DOI：
10.1016/j.bpj.2008.12.907
发表时间：
2009-02-01
期刊：
Conference abstract
影响因子：
作者：
Michael K. Rosen;Pilong Li;Ilidio R.S. Martins;Gaya K. Amarasinghe;Bingke Yu;Junko Umetani
通讯作者：
Junko Umetani

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

DOI：
10.1007/s00705-020-04731-2
发表时间：
2020-09-04
期刊：
ARCHIVES OF VIROLOGY
影响因子：
2.500
作者：
Jens H. Kuhn;Scott Adkins;Daniela Alioto;Sergey V. Alkhovsky;Gaya K. Amarasinghe;Simon J. Anthony;Tatjana Avšič-Županc;María A. Ayllón;Justin Bahl;Anne Balkema-Buschmann;Matthew J. Ballinger;Tomáš Bartonička;Christopher Basler;Sina Bavari;Martin Beer;Dennis A. Bente;Éric Bergeron;Brian H. Bird;Carol Blair;Kim R. Blasdell;Steven B. Bradfute;Rachel Breyta;Thomas Briese;Paul A. Brown;Ursula J. Buchholz;Michael J. Buchmeier;Alexander Bukreyev;Felicity Burt;Nihal Buzkan;Charles H. Calisher;Mengji Cao;Inmaculada Casas;John Chamberlain;Kartik Chandran;Rémi N. Charrel;Biao Chen;Michela Chiumenti;Il-Ryong Choi;J. Christopher S. Clegg;Ian Crozier;John V. da Graça;Elena Dal Bó;Alberto M. R. Dávila;Juan Carlos de la Torre;Xavier de Lamballerie;Rik L. de Swart;Patrick L. Di Bello;Nicholas Di Paola;Francesco Di Serio;Ralf G. Dietzgen;Michele Digiaro;Valerian V. Dolja;Olga Dolnik;Michael A. Drebot;Jan Felix Drexler;Ralf Dürrwald;Lucie Dufkova;William G. Dundon;W. Paul Duprex;John M. Dye;Andrew J. Easton;Hideki Ebihara;Toufic Elbeaino;Koray Ergünay;Jorlan Fernandes;Anthony R. Fooks;Pierre B. H. Formenty;Leonie F. Forth;Ron A. M. Fouchier;Juliana Freitas-Astúa;Selma Gago-Zachert;George Fú Gāo;María Laura García;Adolfo García-Sastre;Aura R. Garrison;Aiah Gbakima;Tracey Goldstein;Jean-Paul J. Gonzalez;Anthony Griffiths;Martin H. Groschup;Stephan Günther;Alexandro Guterres;Roy A. Hall;John Hammond;Mohamed Hassan;Jussi Hepojoki;Satu Hepojoki;Udo Hetzel;Roger Hewson;Bernd Hoffmann;Seiji Hongo;Dirk Höper;Masayuki Horie;Holly R. Hughes;Timothy H. Hyndman;Amara Jambai;Rodrigo Jardim;Dàohóng Jiāng;Qi Jin;Gilda B. Jonson;Sandra Junglen;Serpil Karadağ;Karen E. Keller;Boris Klempa;Jonas Klingström;Gary Kobinger;Hideki Kondō;Eugene V. Koonin;Mart Krupovic;Gael Kurath;Ivan V. Kuzmin;Lies Laenen;Robert A. Lamb;Amy J. Lambert;Stanley L. Langevin;Benhur Lee;Elba R. S. Lemos;Eric M. Leroy;Dexin Li;Jiànróng Lǐ;Mifang Liang;Wénwén Liú;Yàn Liú;Igor S. Lukashevich;Piet Maes;William Marciel de Souza;Marco Marklewitz;Sergio H. Marshall;Giovanni P. Martelli;Robert R. Martin;Shin-Yi L. Marzano;Sébastien Massart;John W. McCauley;Nicole Mielke-Ehret;Angelantonio Minafra;Maria Minutolo;Ali Mirazimi;Hans-Peter Mühlbach;Elke Mühlberger;Rayapati Naidu;Tomohide Natsuaki;Beatriz Navarro;José A. Navarro;Sergey V. Netesov;Gabriele Neumann;Norbert Nowotny;Márcio R. T. Nunes;Are Nylund;Arnfinn L. Økland;Renata C. Oliveira;Gustavo Palacios;Vicente Pallas;Bernadett Pályi;Anna Papa;Colin R. Parrish;Alex Pauvolid-Corrêa;Janusz T. Pawęska;Susan Payne;Daniel R. Pérez;Florian Pfaff;Sheli R. Radoshitzky;Aziz-ul Rahman;Pedro L. Ramos-González;Renato O. Resende;Carina A. Reyes;Bertus K. Rima;Víctor Romanowski;Gabriel Robles Luna;Paul Rota;Dennis Rubbenstroth;Jonathan A. Runstadler;Daniel Ruzek;Sead Sabanadzovic;Jiří Salát;Amadou Alpha Sall;Maria S. Salvato;Kamil Sarpkaya;Takahide Sasaya;Martin Schwemmle;Muhammad Z. Shabbir;Xiǎohóng Shí;Zhènglì Shí;Yukio Shirako;Peter Simmonds;Jana Širmarová;Manuela Sironi;Sophie Smither;Teemu Smura;Jin-Won Song;Kirsten M. Spann;Jessica R. Spengler;Mark D. Stenglein;David M. Stone;Petra Straková;Ayato Takada;Robert B. Tesh;Natalie J. Thornburg;Keizō Tomonaga;Noël Tordo;Jonathan S. Towner;Massimo Turina;Ioannis Tzanetakis;Rainer G. Ulrich;Anna Maria Vaira;Bernadette van den Hoogen;Arvind Varsani;Nikos Vasilakis;Martin Verbeek;Victoria Wahl;Peter J. Walker;Hui Wang;Jianwei Wang;Xifeng Wang;Lin-Fa Wang;Tàiyún Wèi;Heather Wells;Anna E. Whitfield;John V. Williams;Yuri I. Wolf;Zhìqiáng Wú;Xin Yang;Xīnglóu Yáng;Xuejie Yu;Natalya Yutin;F. Murilo Zerbini;Tong Zhang;Yong-Zhen Zhang;Guohui Zhou;Xueping Zhou
通讯作者：
Xueping Zhou