Structural studies of Ebola VP35 mediated immune evasion mechanisms
Structural studies of Ebola VP35 mediated immune evasion mechanisms
批准号:
8368083
负责人:
Gaya K. Amarasinghe
金额:
$24.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-07-01 至 2014-06-30
关键词:
Antiviral AgentsAttentionAttenuatedBerylliumBindingBiochemicalBiologicalBioterrorismC-terminalCategoriesCellsCollaborationsComplementComplexCoupledDataDisease OutbreaksDouble-Stranded RNADouble-Stranded RNA Binding DomainEbola virusElementsGenesGenetic TranscriptionGenomeGoalsGrowthHealthHumanImmuneImmune responseImmune systemImmunosuppressionIn VitroIndiumInfectionInterferon ActivationInterferonsKnowledgeLaboratoriesLeadLengthMediatingMethodsModelingMolecularMutationN-terminalNatural ImmunityNaturePathogenesisPathogenicityPolymerasePopulationProductionPropertyProteinsRNARNA BindingReagentRecombinantsReportingResearchResourcesRoleSignal TransductionStagingStressStructureSurfaceTestingTherapeutic InterventionTranslationsVaccinesViralViral Hemorrhagic FeversViral PackagingViral PathogenesisViral ProteinsVirulenceVirulence FactorsVirus DiseasesWorkbasecofactorcombatdesigneIF-2 Kinasehuman IRF3 proteinimprovedin vivoinnovationinsightinterferon regulatory factor-3loss of functionmedical schoolsmultidisciplinarymutantnovel diagnosticsnovel strategiesnovel therapeuticspathogenprogramsresearch studyresponsetherapy designvaccine developmentviral RNA
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