Is asthma in the elderly a disease of the peripheral airways?

老年人哮喘是末梢气道疾病吗？

• 批准号: nhmrc : 632793
• 负责人: Dr Cheryl Salome
• 金额: $ 33.5万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/asthma-elderly-disease-peripheral-airways/97226
• 关键词: asthma; elderly; disease; peripheral; airways

Elderly asthmatics have poorer clinical outcomes compared with younger asthmatics. The reasons for this are unclear but may involve age-related changes in the disease itself. In this project we aim to show that asthma in the elderly is dominated by abnormalities of very small peripheral airways, in contrast to younger patients where the abnormalities occur in larger airways. The results will provide the basis for new and better targeted treatment strategies for asthma in the elderly.

与年轻哮喘患者相比，老年哮喘患者的临床结局较差。其原因尚不清楚，但可能与疾病本身的年龄相关变化有关。在这个项目中，我们的目的是表明，老年人的哮喘是由非常小的外周气道异常为主，而年轻患者的异常发生在较大的气道。研究结果将为老年人哮喘的新的和更好的针对性治疗策略提供基础。