Does the pattern of ventilation distribution predict airway hyperresponsiveness?

通气分布模式是否可以预测气道高反应性？

• 批准号: nhmrc : 457346
• 负责人: Dr Cheryl Salome
• 金额: $ 17.13万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-pattern-ventilation-airway-hyperresponsiveness/96307
• 关键词: Does; pattern; ventilation; distribution; predict

The tendency for airways to narrow too easily when stimulated is called airway hyperresponsiveness (AHR). AHR is an important feature of asthma, but it also occurs in other diseases, such as chronic obstructive pulmonary disease (COPD) - an airway disease caused by smoking, and cystic fibrosis. People who have AHR have more severe respiratory disease, regardless of which disease they have, and are more likely to develop poor lung function in old age and to be hospitalised or die from their disease. If we can understand the causes of AHR we will have a better understanding of why some people with respiratory disease have poor outcomes. We have recently discovered that, in asthma, there is a very close relationship between AHR and the uneven distribution of air within the lungs. We believe that structural changes in the airways that cause this uneven distribution make the airways prone to AHR. This raises the possibility that factors that cause uneven ventilation in other respiratory diseases might also predispose the airways to AHR. If this is true, it suggests that there is a single physiological basis for AHR in a range of different diseases, and would allow us to focus research more closely on the causes of uneven ventilation. In this project we will measure the relationship between AHR and uneven ventilation in people with asthma, COPD or cystic fibrosis. The study is important because older people with asthma, particularly those with permanently narrowed airways, are likely to have more structural changes in their airways than young asthmatics, whereas people with COPD and cystic fibrosis have a different pattern of both structural changes and airway inflammation from that in asthma. The study will tell us whether there is a consistent relationship between AHR and uneven ventilation. If so, this would be extremely strong evidence that the factors that cause uneven ventilation contribute to AHR, and will point the way to studies of new treatments.

当受到刺激时，气道容易变窄的趋势称为气道高反应性（AHR）。AHR是哮喘的一个重要特征，但它也发生在其他疾病中，如慢性阻塞性肺疾病（COPD）-吸烟引起的气道疾病和囊性纤维化。患有AHR的人患有更严重的呼吸道疾病，无论他们患有哪种疾病，并且更有可能在老年时肺功能不佳，住院或死于疾病。如果我们能够了解AHR的原因，我们将更好地了解为什么一些呼吸道疾病患者的结果很差。我们最近发现，在哮喘中，AHR与肺内空气分布不均匀之间存在非常密切的关系。我们认为，导致这种不均匀分布的气道结构变化使气道容易发生AHR。这就提出了一种可能性，即在其他呼吸道疾病中引起通气不均匀的因素也可能使气道易患AHR。如果这是真的，这表明在一系列不同的疾病中，AHR有一个单一的生理基础，这将使我们能够更密切地关注通气不均匀的原因。在这个项目中，我们将测量AHR与哮喘、COPD或囊性纤维化患者通气不均匀之间的关系。这项研究很重要，因为患有哮喘的老年人，特别是那些永久性气道狭窄的人，可能比年轻的哮喘患者有更多的气道结构变化，而患有COPD和囊性纤维化的人与哮喘患者的结构变化和气道炎症模式不同。这项研究将告诉我们AHR和不均匀通气之间是否存在一致的关系。如果是这样的话，这将是极强有力的证据，表明导致通气不均匀的因素有助于AHR，并将为新治疗方法的研究指明方向。