High Performance, Highly Deployable Head-Only MRI Scanner

高性能、高度可部署的头部 MRI 扫描仪

基本信息

批准号：
8322688
负责人：
Evangelos Trifon Laskaris
金额：
$ 100.04万
依托单位：
GENERAL ELECTRIC GLOBAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8322688
关键词：
Accident and Emergency department Autistic Disorder Beds Brain Brain Diseases Brain Injuries Businesses Clinic Clinical Clinical Research Collaborations Consultations Development Devices Diagnostic Engineering Evaluation Floor Frequencies Functional Magnetic Resonance Imaging Future Goals Government Head Healthcare Heating Hospitals Human Human Volunteers Image Image Analysis Imaging Techniques Institutional Review Boards Investments Lead Location Magnetic Resonance Magnetic Resonance Imaging Mental Depression Mental disorders Military Medicine Motivation Nonhospital Ambulatory Care Facilities Patients Performance Peripheral Peripheral Nerve Stimulation Persons Physiologic pulse Positioning Attribute Power Sources Procedures Process Protocols documentation Radio Radiology Specialty Research Research Personnel Rural Population Scanning Scientist Sensory Services Site Speed Staging Stroke System Techniques Technology Testing Time Traumatic Brain Injury United States National Institutes of Health Weight base clinically relevant combat cryogenics cryostat density design ergonomics flexibility improved light weight meetings nervous system disorder neuroimaging novel operation programs prototype public health relevance simulation volunteer whole body imaging

项目摘要

DESCRIPTION (provided by applicant): The motivation for the proposed program is the realization that the current multi-use whole-body MRI scanners limit optimal neuroimaging. Current scanners are based on the one-size-fits-all concept of whole-body imaging and do not have the full range of functionalities that could be achieved in a scanner designed to image only the brain. GE Global Research and the Mayo Clinic propose to jointly develop and validate a radically new MR system optimized for neuroimaging. This system is based on a revolutionary lightweight magnet, gradient and RF design to permit high quality 3T MRI of the human brain. This new scanner will provide much greater patient comfort, markedly improved image quality, and much higher performance in terms of speed and range of imaging capabilities such as gradient strength and slew rate. In addition, the significant reduction in size and weight will allow the placement of the scanner in locations that are currently inaccessible to whole-body MRI scanners. This program will develop: 1) Enabling cryogen-free magnet and gradient technologies include advanced cryogenic and magnet design, head-only high-performance gradients, an RF coil with integrated fMRI simulation capabilities, and optimized patient ergonomics. 2) A high-performance prototype 3T head-only imaging system, that will be evaluated on human volunteers. 3) Optimized image acquisition protocols and image analysis technology to permit improved assessment of brain disorders. PUBLIC HEALTH RELEVANCE: Global Research and the Mayo Clinic propose to develop a new concept MRI brain scanner that is both lightweight and high performance. This scanner represents a 10 times reduction in weight and can be placed in locations that are easily accessible to patients. Successful implementation of this idea will allow greater availability of advanced neuroimaging to meet a range of neurological and psychiatric disorders, such as depression, autism, traumatic brain injury, and stroke.

描述（由申请人提供）：拟议程序的动机是意识到当前的多用途全身MRI扫描仪限制了最佳神经成像。当前的扫描仪基于全身成像的一定大小的概念，并且没有在旨在仅对大脑成像的扫描仪中实现的全部功能。 GE全球研究和Mayo诊所建议共同开发和验证一种针对神经影像的优化的根本新的MR系统。该系统基于革命性的轻质磁铁，梯度和RF设计，可允许人脑的高质量3T MRI。这款新的扫描仪将提供更大的患者舒适性，明显提高的图像质量，并且在速度和成像功能范围（例如梯度强度和回弹速率）方面的性能更高。此外，大小和重量的显着降低将使扫描仪放置在当前全身MRI扫描仪目前无法接近的位置。该程序将开发：1）启用无低温磁铁和梯度技术，包括高级低温和磁铁设计，仅头部高性能梯度，具有集成fMRI模拟功能的RF线圈以及优化的患者人体工程学。 2）高性能原型3T仅头像成像系统，将对人类志愿者进行评估。 3）优化的图像采集方案和图像分析技术，以改善对脑疾病的评估。公共卫生相关性：全球研究和Mayo诊所建议开发一种新的概念MRI脑扫描仪，既轻量级又高性能。该扫描仪的重量降低了10倍，可以放置在患者易于进入的位置。成功实施这一想法将使高级神经影像学能够获得更大的可用性，以满足一系列神经系统和精神疾病，例如抑郁症，自闭症，创伤性脑损伤和中风。