Arkansas Claude Pepper Older Americans Independence Center at UAMS

阿肯色州 UAMS 的美国老年人独立中心克劳德·佩珀

• 批准号: 8324590
• 负责人: JEANNE Y WEI
• 金额: $ 106.74万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324590
• 关键词: Affect; Age; Aging; American; Arkansas; Basic Science; Caring; Clinical Research; Clinical Trials; Collaborations; Dietary Intervention; Disease; Elderly; Emerging Technologies; Functional disorder; Generations; Goals; Health; Individual; Institution; Intervention; Intervention Studies; Leadership; Learning; Methodology; Methods; Minority; Molecular; Muscle; Muscle Weakness; Muscle function; Myocardial; Myocardium; Nutrient; Nutritional; Outcome; Outreach Research; Performance; Prevention; Recommendation; Research; Research Personnel; Rural; Skeletal Muscle; Source; Supplementation; Technology; Therapeutic; Training; Translating; Translational Research; Translations; age related; base; career development; design; improved; innovation; multidisciplinary; next generation; novel; nutrition; prevent; protein metabolism; standard of care

The theme of the Arkansas OAIC at UAMS is "Translational research on cardiac and skeletal muscle dysfunction in aging and disease." The main goals of the Arkansas OAIC are 1) To promote research that will both provide a mechanistic understanding of the basis for declining skeletal muscle function and myocardial performance with advancing age and translate what is learned from those studies to intervention studies that will ultimately affect nutritional recommendations and standard of care in the elderly; 2) To introduce state-of-the-art methodologies for studying protein metabolism to better enable basic molecular-based studies to ultimately translate the findings to the performance of clinical trials aimed at improving outcomes in elderly individuals; 3) use novel nutritional interventions in the prevention and treatment of cardiac and skeletal muscle weakness; 4) To train a new generation of geriatricians and gerontologists in improving functional independence of older Americans through therapeutic nutritional interventions. These goals will be achieved via the following Specific Aims. Specific Aim 1. Provide scientific, intellectual, and innovation leadership among UAMS investigators. Specific Aim 2. Stimulate translation between basic and clinical research through collaboration and interaction among investigators to improve our understanding of mechanisms contributing to declining skeletal muscle function and myocardial performance with age. Interventions will include, but not be limited to, therapeutic nutrient supplementation. Specific Aim 3. Stimulate incorporation of emerging technologies and novel methods and approaches in analyzing protein metabolism and nutritional interventions for cardiac and skeletal muscle weakness. Specific Aim 4. Serve as a source of advice and collaboration to other institutions (especially OUHSC and other OAICs) regarding technology and expertise in the center theme of the proposal and facilitate multi- and interdisciplinary strategies. Specific Aim 5. Provide career development for future research leaders by increasing the recruitment of young and established investigators In aging, while emphasizing recruitment of minorities to UAMS. Specific Aim 6. Expand the research outreach to maximally include minority representation in all studies. This OAIC would help translate innovative muscle research to improve care, including for the rural elderly.

阿肯色州OAIC在UAMS的主题是“关于衰老和疾病中心脏和骨骼肌功能障碍的转化研究”。 阿肯色欧洲裔OAIC的主要目标是 1）促进将提供机械的研究 了解骨骼肌功能和心肌表现下降的基础，并使年龄的增长转化为干预研究，这些研究最终会影响老年人的营养建议和护理标准； 2）引入最先进的方法来研究蛋白质代谢，以更好地实现基本的基于分子的研究，最终将发现转化为旨在改善老年人结果的临床试验的表现； 3）在预防和治疗心脏和骨骼肌无力方面，使用新颖的营养干预措施； 4）培训新一代的老年医生和老年医生通过治疗营养干预措施改善了老年人的功能独立性。 这些目标将通过以下特定目标实现。 特定目的1。在UAMS调查人员中提供科学，智力和创新领导。 特定目的2。通过研究人员之间的协作和互动来刺激基础研究和临床研究之间的翻译，以提高我们对随着年龄的增长的骨骼肌肉功能和心肌性能下降的机制的理解。干预措施将包括但不限于补充治疗性营养。 特定目的3。刺激新兴技术以及新的方法和方法分析蛋白质代谢和心脏和骨骼肌无力的营养干预措施。 具体目的4.就提案中心主题的技术和专业知识提供了针对其他机构（尤其是OUHSC和其他OAICS）的建议和协作来源，并促进了多学科策略和跨学科策略。 具体目标5。通过增加衰老中的年轻研究者的招募，同时强调向UAM招募少数群体，从而为未来的研究领导者提供职业发展。 具体目的6。将研究范围扩大到最大程度地包括所有研究中的少数族裔代表。 这种OAIC将有助于翻译创新的肌肉研究以改善护理，包括农村老年人。