Arkansas Claude Pepper Older Americans Independence Center at UAMS

阿肯色州 UAMS 的美国老年人独立中心克劳德·佩珀

• 批准号: 8179774
• 负责人: JEANNE Y WEI
• 金额: $ 107.8万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8179774
• 关键词: Arkansas; Claude; Pepper; Older; Americans

The theme of the Arkansas OAIC at UAMS is "Translational research on cardiac and skeletal muscle dysfunction in aging and disease." The main goals of the Arkansas OAIC are 1) To promote research that will both provide a mechanistic understanding of the basis for declining skeletal muscle function and myocardial performance with advancing age and translate what is learned from those studies to intervention studies that will ultimately affect nutritional recommendations and standard of care in the elderly; 2) To introduce state-of-the-art methodologies for studying protein metabolism to better enable basic molecular-based studies to ultimately translate the findings to the performance of clinical trials aimed at improving outcomes in elderly individuals; 3) use novel nutritional interventions in the prevention and treatment of cardiac and skeletal muscle weakness; 4) To train a new generation of geriatricians and gerontologists in improving functional independence of older Americans through therapeutic nutritional interventions. These goals will be achieved via the following Specific Aims. Specific Aim 1. Provide scientific, intellectual, and innovation leadership among UAMS investigators. Specific Aim 2. Stimulate translation between basic and clinical research through collaboration and interaction among investigators to improve our understanding of mechanisms contributing to declining skeletal muscle function and myocardial performance with age. Interventions will include, but not be limited to, therapeutic nutrient supplementation. Specific Aim 3. Stimulate incorporation of emerging technologies and novel methods and approaches in analyzing protein metabolism and nutritional interventions for cardiac and skeletal muscle weakness. Specific Aim 4. Serve as a source of advice and collaboration to other institutions (especially OUHSC and other OAICs) regarding technology and expertise in the center theme of the proposal and facilitate multi- and interdisciplinary strategies. Specific Aim 5. Provide career development for future research leaders by increasing the recruitment of young and established investigators In aging, while emphasizing recruitment of minorities to UAMS. Specific Aim 6. Expand the research outreach to maximally include minority representation in all studies. This OAIC would help translate innovative muscle research to improve care, including for the rural elderly.

UAMS阿肯色州OAIC的主题是“衰老和疾病中心脏和骨骼肌功能障碍的转化研究”。" 阿肯色州OAIC的主要目标是 1)为了促进既能提供一种机制， 了解骨骼肌功能和心肌性能随年龄增长而下降的基础，并将从这些研究中学到的知识转化为干预研究，最终影响老年人的营养建议和护理标准; 2)引入研究蛋白质代谢的最先进方法，以更好地使基于分子的基础研究能够最终将研究结果转化为旨在改善老年人结局的临床试验的性能; 3)在预防和治疗心脏和骨骼肌无力中使用新的营养干预措施; 4)培训新一代的老年病学家和老年病学家，通过治疗性营养干预改善美国老年人的功能独立性。 这些目标将通过以下具体目标实现。 具体目标1.在UAMS调查人员中提供科学，知识和创新领导。 具体目标2。通过研究者之间的合作和互动，促进基础和临床研究之间的转化，以提高我们对骨骼肌功能和心肌性能随年龄下降的机制的理解。干预措施将包括但不限于治疗性营养补充。 具体目标3。促进新兴技术和新方法的整合，分析蛋白质代谢和营养干预对心脏和骨骼肌无力的影响。 具体目标4。作为建议和合作的来源，以其他机构（特别是OUHSC和其他OAIC）有关技术和专业知识的中心主题的建议，并促进多学科和跨学科的战略。 具体目标5.为未来的研究领导者提供职业发展，增加招聘年轻和成熟的研究人员在老龄化，同时强调招聘少数民族到UAMS。 具体目标6.扩大研究范围，最大限度地将少数群体的代表性纳入所有研究。 OAIC将有助于将创新的肌肉研究转化为改善护理，包括农村老年人。