"UAB Metabolomics Workshop: from design to decision"

“UAB代谢组学研讨会：从设计到决策”

• 批准号: 8416292
• 负责人: STEPHEN BARNES
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-18 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8416292
• 关键词: Alabama; American; Applications Grants; Automation; Award; Bioinformatics; Biomedical Research; Biometry; Characteristics; Collaborations; Collection; Communities; Computer software; Consultations; Data; Data Analyses; Data Set; Development; Discipline; Education; Educational process of instructing; Educational workshop; Elements; Ensure; Environment; Evaluation; Experimental Designs; Faculty; Feedback; Fees; Fellowship; Food; Funding; Gender; Goals; Health; Informatics; Investments; Lead; Learning; Location; Mass Spectrum Analysis; Methods; Modification; Nuclear Magnetic Resonance; Participant; Phase; Postdoctoral Fellow; Process; Protocols documentation; Published Comment; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Selection Criteria; Series; Shapes; Site; Statistical Data Interpretation; Students; Technology; Testing; Training; Translational Research; Travel; Underrepresented Minority; Universities; analytical tool; cost; design; disability; education evaluation; experience; graduate student; investigator training; lectures; meetings; metabolomics; programs; research study; responsible research conduct; skills; web site

DESCRIPTION (provided by applicant): This is an application for the development and presentation of a 4-day Workshop on metabolomics. While the framework of all aspects of metabolomics will be presented to the attendees, the ultimate goal of the Workshop is to prepare investigators to advance the use of metabolomics in translational research and to direct highly interdisciplinary teams or collaborations in metabolomic studies. To that end, the Workshop will have a specific focus on development of experimental designs that will allow for the meaningful execution of metabolomics research. In combination with this emphasis, the Workshop will provide an organized, hands-on experience in metabolomics. The goal is to ensure in this round of -omics development, that attendees will learn from experiences gained from the last 15 years of -omics research. In the first year, with strong institutional support, th Workshop will be in a developmental phase and will be restricted to up to 16 participants. This is to carefully test the hands-on experience that will constitute nearly 50% of the Workshop activities before it is expanded to the 40 attendees who will attend the full Workshop in years 2-5. We will use feedback/advice given by the speakers and attendees of the first course to refine all aspects of the course - and continue throughout each year to use both feedback comments and assessment of how former attendees are using metabolomics to guide us in determining the content and shape of subsequent Workshops. The Workshop will consist of five main didactic sections: (1) understanding what metabolomics/metabonomics is and how to design a metabolomics experiment; (2) critical issues in collection and storage of samples; (3) rationales for choosing the analytical tools of metabolomics, mass spectrometry (MS) and nuclear magnetic resonance (NMR); (4) processing of collected metabolomics data and statistical analysis of high dimensional data; and (5) bioinformatics, software and computer resource needs for metabolomics. Attendees will be introduced to each of these through a hands-on experience - they will process samples for both MS and NMR analysis where attendees will be given analysis protocols that range from ideal/optimized to specifically corrupted data. These protocols will be designed to show the consequence of poor design. All samples will be processed so that the attendees can apply the analytical, statistical and bioinformatic methods they've been taught in the didactic sessions. In the last session, attendees and the Workshop faculty will discuss the data that has been obtained. There will be up to 10 student/postdoc fellowships that will be awarded through a competitive process for Workshops in year 2-5. These will consist of the registration, hotel/food costs and travel to the Workshop. Graded registration fees will apply to the other students/postdocs, faculty and non- university attendees. Emphasis will be placed ensuring gender equality and underserved minority recruitment. UAB is a superb environment for this Workshop because of its excellent investment in the technologies needed for metabolomics, the strength of its biostatistic research faculty and its investment in bioinformatics. PUBLIC HEALTH RELEVANCE: The goal of this application is to create an infrastructure supporting metabolomic research and to increase the number of well-trained investigators with the interdisciplinary skills required to perform metabolomics studies. In combination with an emphasis on experimental design and other didactic components of metabolomics, the Workshop will provide an organized, hands-on experience on the practical aspects of metabolomics so that attendees can apply metabolomics to the many intriguing questions in biomedical research that's important to the health of Americans.

描述（由申请人提供）：这是一份用于开发和演示为期 4 天的代谢组学研讨会的申请。虽然代谢组学各个方面的框架将向与会者介绍，但研讨会的最终目标是让研究人员做好准备，推进代谢组学在转化研究中的应用，并指导代谢组学研究中高度跨学科的团队或合作。为此，研讨会将特别关注实验设计的开发，以便有意义地执行代谢组学研究。结合这一重点，研讨会将提供代谢组学方面有组织的实践经验。目标是确保在这一轮组学发展中，与会者能够从过去 15 年组学研究中获得的经验中学习。第一年，在强有力的机构支持下，研讨会将处于发展阶段，参加人数将限制在 16 人以内。这是为了仔细测试实践经验，该经验将构成研讨会活动的近 50%，然后再扩大到 40 名参加者，他们将在第 2-5 年参加完整的研讨会。我们将利用第一门课程的演讲者和参与者提供的反馈/建议来完善课程的各个方面，并在每年继续使用反馈意见和对前参与者如何使用代谢组学的评估来指导我们确定后续研讨会的内容和形式。研讨会将包括五个主要教学部分：（1）了解什么是代谢组学/代谢组学以及如何设计代谢组学实验； （二）样本采集、保存中的关键问题； （3）选择代谢组学、质谱（MS）和核磁共振（NMR）分析工具的理由； (4)收集的代谢组学数据的处理和高维数据的统计分析； (5) 代谢组学的生物信息学、软件和计算机资源需求。与会者将通过实践经验了解其中的每一个 - 他们将处理用于 MS 和 NMR 分析的样品，其中与会者将获得从理想/优化到特定损坏数据的分析方案。这些协议旨在展示不良设计的后果。所有样本都将被处理，以便与会者能够应用他们在教学课程中学到的分析、统计和生物信息学方法。在最后一次会议中，与会者和研讨会教师将讨论已获得的数据。最多 10 名学生/博士后奖学金将通过第 2-5 年研讨会的竞争过程授予。这些费用包括注册费、酒店/食品费和前往研讨会的旅费。分级注册费适用于其他学生/博士后、教师和非大学参加者。 重点将放在确保性别平等和服务不足的少数族裔招聘上。阿拉巴马大学为此次研讨会提供了绝佳的环境，因为它对代谢组学所需的技术进行了出色的投资，其生物统计学研究人员的实力以及对生物信息学的投资。 公共卫生相关性：此应用程序的目标是创建支持代谢组学研究的基础设施，并增加训练有素、具备进行代谢组学研究所需的跨学科技能的研究人员的数量。结合对实验设计和代谢组学其他教学内容的重视，研讨会将提供有关代谢组学实际方面的有组织的实践经验，以便与会者能够将代谢组学应用于生物医学研究中对美国人的健康很重要的许多有趣问题。