MRI Guided Interventions in the Prostate: Development of an Integrated Image-Base

前列腺癌是医学和公共卫生领域面临的最重大挑战之一， 今天的美国医疗体系。其增加的诊断已导致一个虚拟的“流行病的这种疾病。MRI是 由于其允许腺体，其边界， 和周围的组织。我们已经开发了MR引导的前列腺近距离放射治疗， 活检程序，该程序使用开放式0.5T介入MRT系统。 我们建议调整和翻译这些程序，以满足高场MRI提供的主要优势 （3T）。在拟议的研究中，我们计划应用一个交互式的综合磁共振图像引导程序 用于诊断和治疗局限性前列腺癌。该集成系统将允许术前 以及手术室中可在线获得的前列腺的术中MR图像。 挑战在于通过使用多模态增强术中图像数据的信息含量 功能，同时保留术中的交互性和接近实时的功能， 在闭孔高场系统中成像。但如果这一点能够实现， 最大限度地控制肿瘤，最大限度地减少副作用，将提高患者的质量， 治疗后的生活

Prostate cancer represents one of the most significant challenges in medicine and public health, facing the US healthcare system today. Its increased diagnosis has lead to a virtual "epidemic of this disease. MRI is uniquely suited to imaging the prostate as it allows excellent visualization of the gland, its boundary, substructure and all surrounding tissues. We have developed both a MR-guided prostate brachytherapy and biopsy program, which utilizes the open 0.5T interventional MRT system. We propose to adapt and translate these programs to meet the major advantages offered by high-field MRI (3T). In the proposed research we plan to apply an interactive comprehensive MR image- guided program for the diagnosis and treatment of localized prostate cancer. This integrated system will allow preoperative and intraoperative MR images of the prostate to be available on-line in the operating room. The challenge is to increase the information content of intraoperative image data by using multimodal features while at the same time preserving the interactivity and the near-real time features of intraoperative imaging, in a closed bore high-field system. But if this can be achieved the precise delivery of treatment to maximize tumor control, and minimize side effects will be achieved and will improve the patients quality of life after treatment.