MRI Guided Interventions in the Prostate: Development of an Integrated Image-Base

MRI 引导前列腺干预：集成图像库的开发

• 批准号: 8286361
• 负责人: CLARE M TEMPANY
• 金额: $ 14.79万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8286361
• 关键词: Adverse effects; Aftercare; Algorithms; Biopsy; Brachytherapy; Clinical Trials; Data; Data Set; Development; Diagnosis; Diffusion; Discrimination; Disease; Elements; Epidemic; Feedback; Future; Gadolinium; Gland; Goals; Healthcare Systems; Image; Imagery; Intervention; Intravenous; Lead; Lesion; Location; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant neoplasm of prostate; Maps; Measurement; Medicine; Methods; Needle biopsy procedure; Needles; Operating Rooms; Operative Surgical Procedures; Patients; Peripheral; Positioning Attribute; Positron-Emission Tomography; Procedures; Prostate; Protocols documentation; Protons; Public Health; Quality of life; Relative (related person); Research; Scanning; Slice; Specific qualifier value; Spectrum Analysis; Spottings; Structure; Structure of capsule of prostate; Surface; System; Testing; Time; Tissues; Translating; base; gadolinium oxide; image guided therapy; image registration; imaging modality; improved; intraoperative imaging; meetings; molecular imaging; optical imaging; programs; radiologist; rectal; simulation; tool; tumor; virtual

Prostate cancer represents one of the most significant challenges in medicine and public health, facing the US healthcare system today. Its increased diagnosis has lead to a virtual "epidemic of this disease. MRI is uniquely suited to imaging the prostate as it allows excellent visualization of the gland, its boundary, substructure and all surrounding tissues. We have developed both a MR-guided prostate brachytherapy and biopsy program, which utilizes the open 0.5T interventional MRT system. We propose to adapt and translate these programs to meet the major advantages offered by high-field MRI (3T). In the proposed research we plan to apply an interactive comprehensive MR image- guided program for the diagnosis and treatment of localized prostate cancer. This integrated system will allow preoperative and intraoperative MR images of the prostate to be available on-line in the operating room. The challenge is to increase the information content of intraoperative image data by using multimodal features while at the same time preserving the interactivity and the near-real time features of intraoperative imaging, in a closed bore high-field system. But if this can be achieved the precise delivery of treatment to maximize tumor control, and minimize side effects will be achieved and will improve the patients quality of life after treatment.

前列腺癌是医学和公共卫生领域面临的最重大挑战之一， 今天的美国医疗体系。其增加的诊断已导致一个虚拟的“流行病的这种疾病。MRI是 由于其允许腺体，其边界， 和周围的组织。我们已经开发了MR引导的前列腺近距离放射治疗， 活检程序，该程序使用开放式0.5T介入MRT系统。 我们建议调整和翻译这些程序，以满足高场MRI提供的主要优势 （3T）。在拟议的研究中，我们计划应用一个交互式的综合磁共振图像引导程序 用于诊断和治疗局限性前列腺癌。该集成系统将允许术前 以及手术室中可在线获得的前列腺的术中MR图像。 挑战是通过使用多模式来增加术中图像数据的信息内容 功能，同时保留术中的交互性和接近实时的功能， 在闭孔高场系统中成像。但如果这一点能够实现， 最大限度地控制肿瘤，最大限度地减少副作用，将提高患者的质量， 治疗后的生活