Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)

摘要：医疗保健和生物医学研究的交叉正处于拐点， 数字革命的融合、成像、纳米技术、大数据科学和 精准或个性化的医疗。有大量有意义但复杂的信息可以 可以从成像数据中提取，但不能最佳地用于病人护理。癌症护理体现了 当前的挑战包括早期发现、准确区分癌前病变和肿瘤 病变，肿瘤侵袭性的预测，在外科手术中确定浸润性肿瘤边缘 治疗，跟踪肿瘤的演变/转移模式，复发和潜在的获得性耐药性 随着时间的推移进行治疗。在癌症治疗的个性化方面取得了重大进展，例如 免疫疗法，但特定的、相关的和及时的医学数据和信息的可用性是 对于充分发挥精准医学的潜力至关重要。没有任何地方比这更尖锐了 这一点比在手术室和程序室进行干预时更明显。图像处理的新方法 需要指导、数据集成、信息提取和知识转移才能 临床医生充分利用可用的信息，特别是在侵入性治疗之前、期间和之后 程序。我们很高兴重新提交一份关于新的P41生物医学资源中心(BTRC)的提案 名为NCIGT的高级技术(AT-NCIGT)，包括3个TRD、10个新协作和10个新 服务项目，所有这些项目都旨在调查、开发和传播新的形象技术 引导治疗(IGT)。三个组成部分是IGT的肿瘤影像异质性、深度学习 用于IGT和用于IGT的术中装置。这些新技术单独或结合在一起将 允许更好地了解疾病状态、治疗指导、集成/导航和体内 监测组织反应，提高侵入性手术的精确度。 因此，这项提案的总体目标是调查、开发和传播新技术，以 提取新的组织特征(技术研发核心TRD1：成像癌症 异构性；分析它们，并通过最先进的算法和数据使它们可用 治疗方法(深度学习TRD 2)；并实现精确的组织采样、手术导航和 通过新式手术中装置(术中装置用于 IGT：TRD3)。为了有效地传播所有这些新知识，我们有10个新的合作和 10个新的服务项目，并将通过我们建立的机制共享这些新工具，从 目前的BTRC-国家影像指导治疗中心(NCIGT)，该中心继续致力于 IGT向介入放射学、外科、放射肿瘤学和程序化方向的创新 医药。

ABSTRACT: The intersection of healthcare and biomedical research is at an inflection point with the convergence of the digital revolution, advances in imaging, nanotechnology, big data science, and precision or personalized medicine. There is a wealth of meaningful, but complex information that could be extracted from imaging data but is not optimally utilized for patient care. Cancer care exemplifies the current challenges which include early detection, accurate distinction of pre- neoplastic and neoplastic lesions, prediction of tumor aggressiveness, determining infiltrative tumor margins during surgical treatment, tracking tumor evolution/ metastasis pattern, recurrence, and potential acquired resistance to treatments over time. Major strides have been made in the personalization of cancer therapies such as immunotherapy, but the availability of specific, relevant, and timely medical data and information is of critical importance to realizing the full potential of precision medicine. Nowhere is this more acutely evident than during interventions in the operating and procedure rooms. Novel methods of image guidance, data integration, information extraction, and knowledge transfer are needed to enable clinicians to fully leverage the information available, especially before, during and after invasive procedures. We are excited to re-submit a proposal for a new P41 biomedical resource center (BTRC) called Advanced Technologies for NCIGT(AT-NCIGT) with 3 TRDs, 10 new collaborative and 10 new service projects, all of which aim to investigate develop and disseminate new technologies for image guided therapy (IGT). The 3 components are Imaging Cancer Heterogeneity for IGT, Deep Learning for IGT and Intraoperative devices for IGT. These new technologies alone and in combinations will allow for greater understanding of disease state, treatment guidance, integration/navigation and in-vivo monitoring of tissue responses and improve the precision of invasive procedures. Thus the overall goal of this proposal is to investigate, develop and disseminate novel technologies for extracting new tissue characteristics (technology research and development core TRD 1: Imaging cancer heterogeneity; analyze them and make them available through state-of-the-art algorithmic and data curation approaches (Deep Learning TRD 2); and enable precise tissue sampling surgical navigation and in-vivo tissue response through the results of novel Intraoperative devices (Intraoperative devices for IGT: TRD 3). In order to effectively disseminate all this new knowledge we have 10 new collaborative and 10 new service projects and will share these novel tools through our established mechanisms, from current BTRC- National Center for Image Guided Therapy (NCIGT), which continues to be dedicated to the innovating for IGT into interventional radiology, surgery, radiation oncology, and procedure-based medicine.