MR GUIDED FOCUSED ULTRASOUND SURGERY FOR PROSTATE CANCER

MR 引导聚焦超声手术治疗前列腺癌

基本信息

  • 批准号:
    7960874
  • 负责人:
  • 金额:
    $ 5.48万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-08-01 至 2010-07-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary Grant Number: R01-CA109246 Project Start: 11-MAY-2005 Project End: 31-MAR-2010 The fundamental principles of image-guided interventions are tumor detection, navigation, delivery and control of the intervention. The powerful union of focused ultrasound (FUS) and magnetic resonance imaging (MRI) or MR-guided FUS allows for accurate detection of the disease, measurement of tissue temperature changes and confirmation of thermally induced tissue changes. Such an integrated delivery system can provide a non-invasive treatment method for many tumors. We have designed, developed and tested integrated systems for use of FUS, which are currently in clinical trials for treatment of breast fibro-adenomas and uterine leiomyomas, led by this same team of investigators. Prostate cancer represents one of the most significant challenges in medicine and public health, facing the US healthcare system today. It presents an ideal model for this non-invasive thermal ablation method or FUS surgery. It is a discrete tumor, which is accessible, and of an appropriate size for targeted delivery of a focal treatment. MR is uniquely suited to imaging the prostate as it allows excellent visualization of the gland, its substructure and all surrounding tissues. MRI guidance can provide targeting, controlled delivery of the thermal energy and help prevent damage to the surrounding critical anatomic structures. In the proposed research, our goal is to develop an interactive comprehensive MR image-guided FUS system for treatment of localized prostate cancer. Our specific aims are 1) To test transrectal device for MR guided thermal therapy in the prostate. 2) To use MRI to define the target prostate lesions, on the basis of multi-parametric MR image data sets. These images will be analyzed, by registration and segmentation, for target definition and navigation, and then integrated into an on-line thermal dose planning system. 3) To perform phase I human trials to test the feasibility, safety and efficacy of MRgFUS for prostate cancer. These will be done prior to radical prostatectomy, with resulting pathological validation of thermal necrosis. The challenge is to increase the information content of intraoperative image data by using multimodal features, while at the same time preserving the interactivity and the near-real time features of intraoperative imaging. When this can be achieved, the precise delivery of FUS to maximize tumor ablation, and minimize side effects will be possible. Thus, at the conclusion of this project we will be poised to begin larger phase II/III clinical trials, with an industrial partner leading to commercial development of a device for further trials. Benefit to NCIGT Both the Prostate and FUS cores contribute and benefit from this collaboration by means of new scientific opportunities and funding. The Specific Aims require the development of an integrated multi-modal image display system to allow accurate targeting of focal prostate lesions for MR guided FUS. Rapid and spatially accurate thermal imaging will be required, not only at the focal point but at the critical normal, adjacent structures, such as the urethra and neuro-vascular bundles. Benefit to the Project The R01 benefits directly from the expertise within the FUS and Prostate cores. Much of the work now being done in the open-bore setting (Prostate Core) will be adapted and modified for use in the closed bore, high field strength system as outlined in the R01 Specific Aims. Imaging and image-processing advances, such as registration and segmentation, developed within the U41 will also have direct application to this R01.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
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{{ truncateString('CLARE M TEMPANY', 18)}}的其他基金

Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)
先进技术 - 国家影像引导治疗中心 (AT-NCIGT)
  • 批准号:
    10326345
  • 财政年份:
    2021
  • 资助金额:
    $ 5.48万
  • 项目类别:
Administration Core
行政核心
  • 批准号:
    10540774
  • 财政年份:
    2021
  • 资助金额:
    $ 5.48万
  • 项目类别:
Administration Core
行政核心
  • 批准号:
    10907198
  • 财政年份:
    2021
  • 资助金额:
    $ 5.48万
  • 项目类别:
Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)
先进技术 - 国家影像引导治疗中心 (AT-NCIGT)
  • 批准号:
    10540773
  • 财政年份:
    2021
  • 资助金额:
    $ 5.48万
  • 项目类别:
Generation and Dissemination of Enhanced AI/ML-ready Prostate Cancer Imaging Datasets for Public Use
生成和传播增强型 AI/ML 就绪前列腺癌成像数据集供公众使用
  • 批准号:
    10842801
  • 财政年份:
    2021
  • 资助金额:
    $ 5.48万
  • 项目类别:
Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)
先进技术 - 国家影像引导治疗中心 (AT-NCIGT)
  • 批准号:
    10090279
  • 财政年份:
    2021
  • 资助金额:
    $ 5.48万
  • 项目类别:
Administration Core
行政核心
  • 批准号:
    10090280
  • 财政年份:
    2021
  • 资助金额:
    $ 5.48万
  • 项目类别:
Administration Core
行政核心
  • 批准号:
    10326346
  • 财政年份:
    2021
  • 资助金额:
    $ 5.48万
  • 项目类别:
Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patients
图像引导治疗中心 - 用于监测 COVID-19 患者的超声波传感器系统
  • 批准号:
    10224566
  • 财政年份:
    2020
  • 资助金额:
    $ 5.48万
  • 项目类别:
MRI Guided Interventions in the Prostate: Development of an Integrated Image-Base
MRI 引导前列腺干预:集成图像库的开发
  • 批准号:
    8286361
  • 财政年份:
    2011
  • 资助金额:
    $ 5.48万
  • 项目类别:

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