ADMINISTRATIVE

行政核心将为本计划中的每个项目和核心提供管理服务。核心将为PI、Co-Pi、项目领导和核心领导提供所有与奖助金相关活动的财务、行政和文书服务。这些活动包括竞争性续期的准备、非竞争性续期的准备（包括进度报告）、预算的准备、与NIH就续期和所有财务互动进行沟通，以及保证本计划支持的实验室完全符合所有机构、州和联邦法规。核心A还将协调和安排与项目功能相关的所有会议，包括所有项目和核心领导以及各自实验室成员的月度会议，以及内部和外部咨询委员会每年两次的会议。核心A还将与布里格姆妇女医院、贝斯以色列女执事医院和波士顿儿童医院这三个邻近机构的非现场调查人员协调工作，并与DFCI的调查人员进行互动。Gilliland博士是该核心的PI和主任，并将担任整体科学主任和首席行政官。Griffin博士是副主任，将协助这些操作，特别是与DFCI的现场调查员和临床项目有关的事宜。他将协助Gilliland博士监测方案的执行情况并协助方案的制定。阿尔贝托·哈马里略是一位非常熟练的行政管理人员，在管理大型项目拨款的财政和行政事务方面经验丰富。他将担任行政协调员，并与Gilliland博士和Griffin博士协调项目管理和财政监督。Alberto Jamarillo将由拨款管理专家Betsy Kelley和行政助理Mariha Duarte协助，与Gilliland博士和Griffin博士协调，管理参与机构之间的预算，准备包括非竞争性续期在内的报告，与每个参与机构的财务官员进行沟通，并作为这些团体和NIH之间的接口。此外，行政核心将确保遵守有关人体实验（包括性别和少数民族参与）和脊椎动物实验的适当条例。

The Administrative Core will provide management services to each of the Projects and Cores in this Program. The Core will provide financial, adminstrative, and clerical services for the PI, the Co-Pi, Project Leaders, and Core Leaders for all grant-related activities. These activites include the preparation of this competing renewal, non-competing renewals including progress reports, preparation of budgets, communication with the NIH regarding renewals and all financial interactions, and assurance that the labs supported by this Program are in full compliance with all institutional, state and federal regulations. Core A will also coordinate and scheduling all meetings related to the function of the Program, including monthly meetings of all Project and Core Leaders, and members of their respective laboratories, as well as twice yearly meetings of the Internal and External Advisory Boards. Core A will also coordinate efforts with off-site investiators at the three neighboring institutions, Brigham and Women's Hospital, Beth Israel-Deaconess Hospital, and Children's Hospital of Boston, as well as interaction with the investigators at the DFCI. Dr. Gilliland is the PI and Director of this Core, and will serve as the overall scientific director and chief administrator. Dr. Griffin is the Co-Pi and will assist in these operations, particaulrly with regard to matters with the on-site investigators and clinical programs at the DFCI. He will assist Dr. Gilliland in monitoring protocol performance and will assist in protocol development. Alberto Jamarillo is a highly skilled administrator with experience in management of fiscal and administrative matters for large program project grants. He will serve as Administrative Facilitator, and coordinate Program administration and fiscal oversight with Dr. Gilliland and Dr. Griffin. Alberto Jamarillo will be assisted by Betsy Kelley, a Grants Management Specialist/Post Award, and Mariha Duarte, an administrative assistant, in coordination with Dr. Gilliland and Dr. Griffin, to manage budgets between participating institutions, prepare reports including noncompeting renewals, interface with the financial officers of each participating institution in the Program, and serve as an interface between these groups and the NIH. In addition, the Administrative Core will assure compliance with appropriate regulations regarding experimentation with human subjects, (including gender and minority participation) and vertebrate animals.