IDENTIFICATION AND PRECLINICAL TESTING OF MICROBICIDES FOR HPV

HPV 杀菌剂的鉴定和临床前测试

基本信息

  • 批准号:
    8358113
  • 负责人:
  • 金额:
    $ 3.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Anogenital Human Papillomaviruses (HPVs) are the most common sexually transmitted pathogen and the primary cause of cervical cancer. A nonhuman model of PV infection using Rhesus papillomavirus (RhPV1) was recently developed at TNPRC through a pilot project. We were able to confirm infection of 5 of 5 rhesus with indications of progression to precancerous lesions, typical of HPV. The R21 Phase of this grant screened a database of 4.5 million small molecules, and have identified several candidate HPV-specific microbicides for testing. To begin the R33 phase of this proposal with studies in a nonhuman primate model for anogenital HPV infection, we conducted both serological and molecular screening of 25 female Rhesus macaques to assess prior exposure to RhPV1 and have identified 12 seronegative females that will go forward for the study. We have also developed a large stock of the challenge virus to be used for the proposed inoculations and await testing of our candidate microbicide compounds for reduction or arrest of viremia and progression of RhPV1 anogenital papillomavirus infections in the nonhuman primate.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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VICKI L TRAINA-DORGE其他文献

VICKI L TRAINA-DORGE的其他文献

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{{ truncateString('VICKI L TRAINA-DORGE', 18)}}的其他基金

Effect of immunization route and prior immunity for a live attenuated varicella AIDS vaccine
水痘艾滋病减毒活疫苗免疫途径和既往免疫效果的影响
  • 批准号:
    9141565
  • 财政年份:
    2016
  • 资助金额:
    $ 3.72万
  • 项目类别:
ANIMAL MODELS TO DESIGN AND EVALUATE IMPROVED VZV VACCINES
用于设计和评估改进的 VZV 疫苗的动物模型
  • 批准号:
    8358056
  • 财政年份:
    2011
  • 资助金额:
    $ 3.72万
  • 项目类别:
MOLECULAR PATHOGENESIS OF VARICELLA ZOSTER VIRUS INFECTION
水痘带状疱疹病毒感染的分子发病机制
  • 批准号:
    8358032
  • 财政年份:
    2011
  • 资助金额:
    $ 3.72万
  • 项目类别:
RESPIRATORY SYNCYTIAL VIRUS EFFICACY STUDY IN AFRICAN GREEN MONKEYS
非洲绿猴呼吸道合胞病毒功效研究
  • 批准号:
    8173023
  • 财政年份:
    2010
  • 资助金额:
    $ 3.72万
  • 项目类别:
MOLECULAR PATHOGENESIS OF VARICELLA ZOSTER VIRUS INFECTION
水痘带状疱疹病毒感染的分子发病机制
  • 批准号:
    8172923
  • 财政年份:
    2010
  • 资助金额:
    $ 3.72万
  • 项目类别:
IDENTIFICATION AND PRECLINICAL TESTING OF MICROBICIDES FOR HPV
HPV 杀菌剂的鉴定和临床前测试
  • 批准号:
    8173024
  • 财政年份:
    2010
  • 资助金额:
    $ 3.72万
  • 项目类别:
RESPIRATORY SYNCYTIAL VIRUS EFFICACY STUDY IN AFRICAN GREEN MONKEYS
非洲绿猴呼吸道合胞病毒功效研究
  • 批准号:
    7958713
  • 财政年份:
    2009
  • 资助金额:
    $ 3.72万
  • 项目类别:
SIMIAN VARICELLA VIRUS INFECTION AND LATENCY IN THE NONHUMAN PRIMATE
非人类灵长类动物中的猿水痘病毒感染和潜伏期
  • 批准号:
    7958580
  • 财政年份:
    2009
  • 资助金额:
    $ 3.72万
  • 项目类别:
ANIMAL MODELS TO DESIGN AND EVALUATE IMPROVED VZV VACCINES
用于设计和评估改进的 VZV 疫苗的动物模型
  • 批准号:
    7958612
  • 财政年份:
    2009
  • 资助金额:
    $ 3.72万
  • 项目类别:
IDENTIFICATION AND PRECLINICAL TESTING OF MICROBICIDES FOR HPV
HPV 杀菌剂的鉴定和临床前测试
  • 批准号:
    7958714
  • 财政年份:
    2009
  • 资助金额:
    $ 3.72万
  • 项目类别:

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