NONHUMAN PRIMATE CORE FOR THE CENTER FOR AIDS RESEARCH

艾滋病研究中心的非人类灵长类核心

• 批准号: 8358049
• 负责人: ANDREW A LACKNER
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358049
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Autopsy; Biopsy; Blood; Clinical; Clinical Chemistry; Clinical Management; Collection; Confocal Microscopy; Feces; Flow Cytometry; Funding; Grant; Hematology; Immunization; Immunology; Investigation; Laboratories; Liquid substance; Microbiology; Modeling; National Center for Research Resources; Ovum; Parasites; Pathologic; Primates; Principal Investigator; Procedures; Research; Research Infrastructure; Research Personnel; Resources; Services; Source; United States National Institutes of Health; Viral; animal care; cost; molecular pathology; nonhuman primate; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objective of the nonhuman primate core is to provide highly integrated clinical management and laboratory investigations using the nonhuman primate model of AIDS to CFAR investigators. The core consists of clinical and laboratory components as well as a pilot program. The clinical component acquires and cares for the animals and performs animal procedures such as immunization, blood draws, fluid collection etc. The laboratory component of the core performs hematology, clinical chemistry, ova and parasite examination of feces, flow cytometry, microbiology, and pathologic examination of all necropsies and biopsies performed on animals utilized in these studies. The core also provides viral stocks, viral isolation, immunology, molecular pathology and confocal microscopy services. The core supports 22 CFAR investigators and has contributed directly to 3 P01's, 10 R01's and 2 R21's. The CFAR pilot has funded 16 pilots including three in the last year.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 非人灵长类核心的目标是提供高度集成的临床管理和实验室调查使用非人灵长类艾滋病模型的CFAR调查。 核心包括临床和实验室部分以及试点计划。 临床部分获取和照顾动物，并执行动物程序，如免疫接种，抽血，液体收集等。 核心的实验室部分对这些研究中使用的动物进行血液学、临床化学、粪便虫卵和寄生虫检查、流式细胞术、微生物学以及所有尸检和活检的病理学检查。 该中心还提供病毒储备、病毒分离、免疫学、分子病理学和共聚焦显微镜服务。 该核心支持22名CFAR调查员，并直接为3名P01、10名R 01和2名R21做出了贡献。 CFAR试点项目资助了16个试点项目，其中包括去年的3个。