NONHUMAN PRIMATE CORE FOR THE CENTER FOR AIDS RESEARCH

艾滋病研究中心的非人类灵长类核心

• 批准号: 8358049
• 负责人: ANDREW A LACKNER
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358049
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Autopsy; Biopsy; Blood; Clinical; Clinical Chemistry; Clinical Management; Collection; Confocal Microscopy; Feces; Flow Cytometry; Funding; Grant; Hematology; Immunization; Immunology; Investigation; Laboratories; Liquid substance; Microbiology; Modeling; National Center for Research Resources; Ovum; Parasites; Pathologic; Primates; Principal Investigator; Procedures; Research; Research Infrastructure; Research Personnel; Resources; Services; Source; United States National Institutes of Health; Viral; animal care; cost; molecular pathology; nonhuman primate; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objective of the nonhuman primate core is to provide highly integrated clinical management and laboratory investigations using the nonhuman primate model of AIDS to CFAR investigators. The core consists of clinical and laboratory components as well as a pilot program. The clinical component acquires and cares for the animals and performs animal procedures such as immunization, blood draws, fluid collection etc. The laboratory component of the core performs hematology, clinical chemistry, ova and parasite examination of feces, flow cytometry, microbiology, and pathologic examination of all necropsies and biopsies performed on animals utilized in these studies. The core also provides viral stocks, viral isolation, immunology, molecular pathology and confocal microscopy services. The core supports 22 CFAR investigators and has contributed directly to 3 P01's, 10 R01's and 2 R21's. The CFAR pilot has funded 16 pilots including three in the last year.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 非人灵长类动物核心的目标是为CFAR研究人员提供高度集成的临床管理和实验室研究，使用非人类灵长类艾滋病模型。核心部分包括临床和实验室部分以及一个试点项目。临床部分获取和照顾动物，并执行动物程序，如免疫接种、抽血、收集液体等。核心实验室部分进行血液学、临床化学、粪便卵子和寄生虫检查、流式细胞仪、微生物学，以及对这些研究中使用的动物进行的所有身体和活组织的病理检查。CORE还提供病毒储存、病毒分离、免疫学、分子病理学和共聚焦显微镜服务。 该核心支持了22名中国空军飞行员，并直接为3名P01飞行员S、10名中国飞行员S和2名中国飞行员S做出了贡献。中国空军飞行员资助了16名飞行员，其中包括去年的3名。