INTRATHECAL HUMORAL RESPONSES AND DEVELOPMENT OF SIV M-TROPIC VARIANTS IN CNS

CNS 中 SIV M-TROPIC 变体的鞘内体液反应和发展

• 批准号: 8358119
• 负责人: ANDREW A LACKNER
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358119
• 关键词: Address; Antibody Formation; Data; Development; Fostering; Funding; Grant; Infection; National Center for Research Resources; Population; Prevalence; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; SIV; Site; Source; United States National Institutes of Health; Variant; Viral; cost; macrophage; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Sustained SIV infection of the CNS depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. Concomitantly, the CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response in general to control M-tropic strains. We investigated the temporal course of the intrathecal neutralizing activity and found an inverse relationship between the magnitude of neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.

这个子项目是利用这些资源的众多研究子项目之一