INTRATHECAL HUMORAL RESPONSES AND DEVELOPMENT OF SIV M-TROPIC VARIANTS IN CNS

CNS 中 SIV M-TROPIC 变体的鞘内体液反应和发展

• 批准号: 8358119
• 负责人: ANDREW A LACKNER
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358119
• 关键词: Address; Antibody Formation; Data; Development; Fostering; Funding; Grant; Infection; National Center for Research Resources; Population; Prevalence; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; SIV; Site; Source; United States National Institutes of Health; Variant; Viral; cost; macrophage; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Sustained SIV infection of the CNS depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. Concomitantly, the CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response in general to control M-tropic strains. We investigated the temporal course of the intrathecal neutralizing activity and found an inverse relationship between the magnitude of neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 中枢神经系统的持续SIV感染取决于巨噬细胞（M-tropic）菌株，这些菌株通常很容易中和。同时，中枢神经系统通常被认为是一种促进Mtropic准特性复制的免疫特权部位。然而，有限的数据解决了鞘内抗体反应或通常在控制M-热带菌株中的体液反应的作用。我们研究了鞘内中和活性的时间过程，并发现中和的大小与M-热带人群的患病率之间存在反比关系。这些研究表明在实验SIV感染中，在中枢神经系统中，体液反应在抑制M-热带病毒物种中的作用。