INTRATHECAL HUMORAL RESPONSES AND DEVELOPMENT OF SIV M-TROPIC VARIANTS IN CNS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心赠款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 CNS的持续SIV感染依赖于嗜巨噬细胞（M-嗜性）菌株，这些菌株通常易于中和。同时，CNS通常被认为是促进M嗜性准种复制的免疫特权位点。然而，有有限的数据解决鞘内抗体反应或体液反应的作用，一般控制M-嗜性菌株。我们调查了鞘内中和活性的时间进程，发现中和的幅度和M-热带人群的患病率之间呈反比关系。这些研究表明，在实验性SIV感染中，体液反应在抑制CNS中M嗜性病毒种类中发挥作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Sustained SIV infection of the CNS depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. Concomitantly, the CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response in general to control M-tropic strains. We investigated the temporal course of the intrathecal neutralizing activity and found an inverse relationship between the magnitude of neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.