Studies Toward the Total Synthesis of Leiodelide

描述(由申请人提供)：总体研究计划详细介绍了拟议的有机化学进展调查，以便为制备来碘甲素制定成功的战略。研究设计将解决复杂恶唑合成问题的具体需要。我们将研究新的交叉偶联策略，以具体探索构造跳过的(Z，Pound)-来碘内酯A的二烯所带来的挑战。我们的计划还将探索新的SE‘反应和试剂，以形成具有高立体选择性的关键键。目前还没有关于雷公藤甲素的成功治疗的报道。 与公共卫生相关：Leiodelide A是一种独特的19个成员的代谢物，可以从一种罕见的深水海绵中获得非常少量的代谢物。该化合物表现出很强的抗癌活性，对几种重要的癌细胞株具有选择性的细胞毒作用。在该地区，非常需要新的化疗药物。我们的合成将提供一项突破，为制备必要的材料建立一条领先的路线，以支持生物学研究和确定潜在药物的生物学作用机制的努力。

DESCRIPTION (provided by applicant): The overall research plan details a proposed investigation of advances in organic chemistry In order to devise a successful strategy for the preparation of leiodelide A. The research design will address specific needs to address problems for the synthesis of complex oxazoles. New cross-coupling strategies will be studied to specifically explore the challenges imposed for construction of the skipped (Z,pound)- diene of leiodelide A. Our plans will also explore new SE' reactions and reagents for the key formation of critical bonds with high stereoselectivity. No reports of successful efforts toward leiodelide A have been published. Public Health Relevance: Leiodelide A is a unique nineteen-membered metabolite which is available in very small quantities from a rare deep-water sponge. The compound displays very potent anticancer activity with selective cytotoxicity against several important classes of cancer cell lines. In the area, there is a great need for new chemotherapeutic agents. Our synthesis would provide a breakthrough which establishes a leading route for the preparation of materials necessary to support biological studies and efforts to define the biological mechanism of action of potential drugs.