Studies Toward the Total Synthesis of Leiodelide

描述（由申请人提供）：总体研究计划详细介绍了有机化学进展的拟议调查，以便为leiodelide a的制备设计一个成功的策略。研究设计将解决复杂恶唑合成问题的具体需求。我们还将研究新的交叉偶联策略，以探索构建leiodelide a的跳过(Z,pound)-二烯所面临的挑战。我们还将探索新的SE'反应和试剂，以形成具有高立体选择性的关键键。目前还没有针对碘化物A的成功研究报告。

DESCRIPTION (provided by applicant): The overall research plan details a proposed investigation of advances in organic chemistry In order to devise a successful strategy for the preparation of leiodelide A. The research design will address specific needs to address problems for the synthesis of complex oxazoles. New cross-coupling strategies will be studied to specifically explore the challenges imposed for construction of the skipped (Z,pound)- diene of leiodelide A. Our plans will also explore new SE' reactions and reagents for the key formation of critical bonds with high stereoselectivity. No reports of successful efforts toward leiodelide A have been published. Public Health Relevance: Leiodelide A is a unique nineteen-membered metabolite which is available in very small quantities from a rare deep-water sponge. The compound displays very potent anticancer activity with selective cytotoxicity against several important classes of cancer cell lines. In the area, there is a great need for new chemotherapeutic agents. Our synthesis would provide a breakthrough which establishes a leading route for the preparation of materials necessary to support biological studies and efforts to define the biological mechanism of action of potential drugs.