Studies Toward the Total Synthesis of Leiodelide

描述（由申请人提供）：总体研究计划详细说明了有机化学进展的拟议调查，以设计一个成功的策略来制备莱碘来特A。研究设计将解决特定的需求，以解决复杂恶唑合成的问题。将研究新的交叉偶联策略，以专门探索构建leiodelide A的跳跃（Z，磅）-二烯所面临的挑战。我们的计划还将探索新的SE'反应和试剂，用于形成具有高立体选择性的关键键。目前还没有关于利碘来胺A的成功研究的报道。 公共卫生相关性：Leiodelide A是一种独特的十九元代谢物，可从一种罕见的深水海绵中获得非常少量的Leiodelide A。该化合物显示出非常有效的抗癌活性，对几种重要类型的癌细胞系具有选择性细胞毒性。在该领域，存在对新的化疗剂的巨大需求。我们的合成将提供一个突破，它建立了一个领先的路线，用于制备必要的材料，以支持生物学研究和努力，以确定潜在药物的生物学作用机制。

DESCRIPTION (provided by applicant): The overall research plan details a proposed investigation of advances in organic chemistry In order to devise a successful strategy for the preparation of leiodelide A. The research design will address specific needs to address problems for the synthesis of complex oxazoles. New cross-coupling strategies will be studied to specifically explore the challenges imposed for construction of the skipped (Z,pound)- diene of leiodelide A. Our plans will also explore new SE' reactions and reagents for the key formation of critical bonds with high stereoselectivity. No reports of successful efforts toward leiodelide A have been published. Public Health Relevance: Leiodelide A is a unique nineteen-membered metabolite which is available in very small quantities from a rare deep-water sponge. The compound displays very potent anticancer activity with selective cytotoxicity against several important classes of cancer cell lines. In the area, there is a great need for new chemotherapeutic agents. Our synthesis would provide a breakthrough which establishes a leading route for the preparation of materials necessary to support biological studies and efforts to define the biological mechanism of action of potential drugs.