A CBPR INVESTIGATION OF TRAFFIC POLLUTION AND CVD IN PUERTO RICAN ADULTS

我们分析了来自波多黎各老年人前瞻性队列的横断面数据， 靠近主要道路和居住地附近的交通密度。这项分析没有评估 因为队列研究最初并不是为了评估这种暴露。尽管如此， 作为替代，我们已经证明了交通接近度与高血压，血压， C反应蛋白和血清白蛋白。据oiu所知，这是第一项评估波多黎各人口中交通暴露和心血管疾病（CVD）标志物的研究，该人口具有高风险因素和心血管疾病的患病率。有竞争性的证据表明，细颗粒物（PM2.5）与CVD有关。然而，PM的这一部分在城市内的地理区域分布相当均匀，但在交通繁忙的情况下几乎没有增加。然而，超细颗粒物污染（UFP）是一种非常小的颗粒，已被证明在高速公路和交通繁忙的道路附近局部升高。除了我们的研究之外，还显示了交通和CVD之间的联系。 因此，我们将解决交通污染在波多黎各人口健康差异中的作用，并制定证据证明UFP和CVD之间是否存在因果关系。我们提出了三个以社区为基础的参与式研究，积极参与我们的社区合作伙伴在研究过程中。研究一将建立在我们的初步工作，并在我们的研究区域开发一个UFP暴露模型，以测试环境UFP暴露与核心队列中CVD的关联（中心项目1）。第二项研究将在核心队列的20名参与者的家中安装HEPA空气过滤器，并评估减少家中的UFP是否与炎症标志物的改善有关，包括C反应蛋白，IL 6，纤维蛋白原和TNF-α。研究三将开发和传播 向当地波多黎各人提供有关交通相关污染和心血管疾病的教育材料。

We have analyzed cross sectional data from the Prospective Cohort of Older Puerto Ricans for the effects of proximity to major roadways and density of traffic near their residences. This analysis did not assess levels of pollution because the cohort study was not originally designed to assess this exposure. Still, using traffic as a proxy, we have demonstrated associations between traffic proximity and hypertension, blood pressure, C-reactive protein and serum albumin. To oiu- knowledge this is the first study to assess traffic exposure and cardiovascular disease (CVD) markers in a Puerto Rican population, a population that has high prevalence of risk factors and cardiovascular diseases. There is competing evidence that fine particulate matter (PM2.5) is associated with CVD. However, this fraction of PM is spread fairly evenly across geographic areas with variation within cities, but little increase next to heavy traffic. Ultrafine particulate pollution (UFP), which are extremely small particles have, however, been shown to be elevated locally near highways and heavily traveled roadways. Research besides ours also has shown associations between proximity to traffic and CVD. Thus, we will address both the role of traffic pollution in health disparities in the Puerto Rican population and develop evidence about whether there is a causal link between UFP and CVD. We propose three community-based participatory research studies that actively engage our community partners in the research process. Study one will build on our preliminary work and develop a model of UFP exposure across our study area in order to test associations of ambient UFP exposure with CVD in the core cohort (project 1 for the center). Study two will install HEPA air filtration in homes of 20 participants in the core cohort and assess whether reducing UFP in the home is associated with improvements in markers of inflammation, including C-reactive protein, IL6, fibrinogen and TNF-a. Study three will develop and disseminate educational materials about traffic-related pollution and CVD to the local Puerto Rican population.