Advancing UAF SNRP
推进 UAF SNRP
基本信息
- 批准号:8329739
- 负责人:
- 金额:$ 9.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-09-30 至 2014-04-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAdvisory CommitteesAffectAlaskaAlaska NativeAnimal ModelArctic RegionsAreaAwardBasic ScienceBiochemicalBiomedical ResearchBudgetsCaliforniaCollaborationsCounselingDevelopmentEducationEnsureEnvironmentFacultyFundingGrantGrowthHealthHome environmentHomeostasisHousingInstitutionLaboratoriesLeadLeadershipMinorityMinority-Serving InstitutionMolecularNatural ResourcesNeuronsNeurosciencesNeurosciences ResearchOutcomePhilosophyPhysiologicalPopulationPublicationsPublishingRecommendationRequest for ProposalsResearchResearch InfrastructureResearch PersonnelResearch ProposalsResearch TrainingRoleSan FranciscoScienceSenior ScientistSerotoninStructureStudentsSystemTechnologyTrainingTraining ProgramsTravelU-Series Cooperative AgreementsUnited StatesUnited States National Institutes of HealthUniversitiesanimal facilitybaseexperiencefrontiergraduate studenthealth disparityimprovedinterestmemberneglectneuroprotectionneuroregulationoutreachprogramssuccess
项目摘要
The isolation and extreme natural conditions inherent in Alaska provide University of Alaska Fairbanks (UAF) neuroscientists and their collaborators an opportunity to explore a variety of health issues affecting the many unique Native Alaskan and arctic populations. Focused on a theme of neuroprotection and adaptation, the SNRP I program approached neuroscience questions from a cellular and molecular perspective. The SNRP II proposal seeks to continue and strengthen this theme by proposing projects that examine neural control at the system, cellular and molecular levels. This SNRP II cooperative agreement proposal is based on the progress achieved by UAF SNRP I over the last 4 years. The successful tenure of 2 neuroscience faculty members and the training provided to other faculty members validates the initial premise that high quality basic research leads to increased opportunities for faculty and students in the neurosciences at UAF. Our four aims provide the framework for the continued growth of the UAF SNRP program: (1) To initiate new research programs strengthening the theme of neuronal adaptation and control at the system, cellular and molecular level. (2) To strengthen the administrative core thereby ensuring a more effective research environment. (3) To emphasize graduate neuroscience education by strengthening the educational infrastructure. (4) To expand undergraduate opportunities for neuroscience research.
A new administrative structure consisting of a Scientific Director and Associate Director is proposed to counsel project leaders on proposal development. Outstanding senior scientists will serve as advisors on Program Advisory Committee (PAC) and Scientific Advisory Committee (SAC) to provide recommendations regarding program and research direction. Major projects explore the role of serotonin in homeostasis. The expanded research opportunities offered by SNRP II will stimulate the active participation of Alaska Native students in the projects and will increase the number of Alaskan Native students active in hypothesis-based neuroscience research.
阿拉斯加固有的孤立和极端自然条件为阿拉斯加Fairbanks大学(UAF)神经科学家及其合作者提供了探索各种健康问题的机会,这些健康问题影响了许多独特的本地阿拉斯加和北极人口。 SNRP I计划以神经保护和适应为主题,从细胞和分子的角度解决了神经科学问题。 SNRP II提案试图通过提出研究系统,细胞和分子水平的神经控制的项目来继续并加强这一主题。该SNRP II合作协议提案基于过去4年中UAF SNRP I取得的进展。 2位神经科学教师的成功任期以及向其他教职员工提供的培训证实了最初的前提,即高质量的基础研究导致UAF神经科学中教职员工和学生的机会增加。我们的四个目标为UAF SNRP计划的持续增长提供了一个框架:(1)启动新的研究计划增强了系统的神经元适应和控制主题,细胞和分子水平。 (2)加强行政核心,从而确保更有效的研究环境。 (3)通过加强教育基础设施来强调研究生神经科学教育。 (4)扩大神经科学研究的本科机会。
提议由科学主任和副主任组成的新行政结构,旨在为项目负责人提供建议的发展。杰出的高级科学家将担任计划咨询委员会(PAC)和科学咨询委员会(SAC)的顾问,以提供有关计划和研究方向的建议。主要项目探讨5-羟色胺在稳态中的作用。 SNRP II提供的扩大的研究机会将刺激阿拉斯加土著学生在项目中的积极参与,并将增加活跃于假设基于假设的神经科学研究的阿拉斯加本地学生的数量。
项目成果
期刊论文数量(62)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
D-cycloserine 24 and 48 hours after asphyxial cardiac arrest has no effect on hippocampal CA1 neuropathology.
窒息心脏骤停后 24 小时和 48 小时 D-环丝氨酸对海马 CA1 神经病理学没有影响。
- DOI:10.1038/jcbfm.2014.135
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:Combs,VélváM;Crispell,HeatherD;Drew,KellyL
- 通讯作者:Drew,KellyL
Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-α.
- DOI:10.1002/jnr.22748
- 发表时间:2012-01
- 期刊:
- 影响因子:4.2
- 作者:Barth, Brian M.;Gustafson, Sally J.;Kuhn, Thomas B.
- 通讯作者:Kuhn, Thomas B.
Arctic ground squirrel neuronal progenitor cells resist oxygen and glucose deprivation-induced death.
- DOI:10.4331/wjbc.v7.i1.168
- 发表时间:2016-02-26
- 期刊:
- 影响因子:0
- 作者:Drew, Kelly L;Wells, Matthew;Kelleher-Andersson, Judith
- 通讯作者:Kelleher-Andersson, Judith
Chronic nicotine and ethanol exposure both disrupt central ventilatory responses to hypoxia in bullfrog tadpoles.
- DOI:10.1016/j.resp.2013.04.004
- 发表时间:2013-07-01
- 期刊:
- 影响因子:2.3
- 作者:Taylor, Barbara E.;Brundage, Cord M.;McLane, Lisa H.
- 通讯作者:McLane, Lisa H.
Mechanisms of innate preconditioning towards ischemia/anoxia tolerance: Lessons from mammalian hibernators.
缺血/缺氧耐受的先天预处理机制:哺乳动物冬眠者的教训。
- DOI:
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Bhowmick,Saurav;Drew,KellyL
- 通讯作者:Drew,KellyL
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