Advancing UAF SNRP

阿拉斯加固有的隔离和极端自然条件为阿拉斯加费尔班克斯大学（UAF）的神经科学家和他们的合作者提供了一个探索影响许多独特的阿拉斯加原住民和北极人口的各种健康问题的机会。SNRP I项目以神经保护和适应为主题，从细胞和分子的角度探讨神经科学问题。SNRP II提案旨在通过提出在系统，细胞和分子水平上检查神经控制的项目来继续和加强这一主题。该SNRP II合作协议提案是基于UAF SNRP I在过去4年中取得的进展。两名神经科学教职员工的成功任职以及对其他教职员工的培训，验证了高质量的基础研究为UAF神经科学教职员工和学生带来更多机会的最初前提。我们的四个目标为UAF SNRP项目的持续发展提供了框架：(1)在系统、细胞和分子水平上启动新的研究项目，加强神经元适应和控制的主题。(2)加强行政核心，从而确保更有效的研究环境。(3)加强教育基础设施建设，重视神经科学研究生教育。(4)扩大本科生从事神经科学研究的机会。

The isolation and extreme natural conditions inherent in Alaska provide University of Alaska Fairbanks (UAF) neuroscientists and their collaborators an opportunity to explore a variety of health issues affecting the many unique Native Alaskan and arctic populations. Focused on a theme of neuroprotection and adaptation, the SNRP I program approached neuroscience questions from a cellular and molecular perspective. The SNRP II proposal seeks to continue and strengthen this theme by proposing projects that examine neural control at the system, cellular and molecular levels. This SNRP II cooperative agreement proposal is based on the progress achieved by UAF SNRP I over the last 4 years. The successful tenure of 2 neuroscience faculty members and the training provided to other faculty members validates the initial premise that high quality basic research leads to increased opportunities for faculty and students in the neurosciences at UAF. Our four aims provide the framework for the continued growth of the UAF SNRP program: (1) To initiate new research programs strengthening the theme of neuronal adaptation and control at the system, cellular and molecular level. (2) To strengthen the administrative core thereby ensuring a more effective research environment. (3) To emphasize graduate neuroscience education by strengthening the educational infrastructure. (4) To expand undergraduate opportunities for neuroscience research. A new administrative structure consisting of a Scientific Director and Associate Director is proposed to counsel project leaders on proposal development. Outstanding senior scientists will serve as advisors on Program Advisory Committee (PAC) and Scientific Advisory Committee (SAC) to provide recommendations regarding program and research direction. Major projects explore the role of serotonin in homeostasis. The expanded research opportunities offered by SNRP II will stimulate the active participation of Alaska Native students in the projects and will increase the number of Alaskan Native students active in hypothesis-based neuroscience research.