Advancing UAF SNRP

阿拉斯加与生俱来的与世隔绝和极端的自然条件为阿拉斯加大学费尔班克斯分校(UAF)的神经科学家和他们的合作者提供了一个机会，来探索影响许多独特的阿拉斯加和北极原住民的各种健康问题。SNRP I计划以神经保护和适应为主题，从细胞和分子的角度探讨神经科学问题。SNRP II提案试图通过提出在系统、细胞和分子水平上检查神经控制的项目来继续和加强这一主题。该SNRP II合作协议提案是基于UAF SNRP I在过去4年中取得的进展。两名神经科学教员的成功任职和为其他教员提供的培训证实了高质量的基础研究为UAF的教职员工和学生带来更多神经科学机会的最初前提。我们的四个目标为UAF SNRP计划的持续发展提供了框架：(1)启动新的研究计划，在系统、细胞和分子水平上加强神经元适应和控制的主题。(2)加强行政核心，确保更有效的研究环境。(3)加强研究生神经科学教育，加强教育基础设施建设。(4)扩大本科生神经科学研究机会。 提议设立一个新的行政结构，由一名科学主任和一名副主任组成，就提案的制定向项目领导人提供咨询。杰出的资深科学家将担任计划咨询委员会(PAC)和科学咨询委员会(SAC)的顾问，就计划和研究方向提供建议。重大项目探索5-羟色胺在动态平衡中的作用。SNRP II提供的更多研究机会将刺激阿拉斯加原住民学生积极参与这些项目，并将增加阿拉斯加原住民学生活跃在基于假设的神经科学研究的数量。

The isolation and extreme natural conditions inherent in Alaska provide University of Alaska Fairbanks (UAF) neuroscientists and their collaborators an opportunity to explore a variety of health issues affecting the many unique Native Alaskan and arctic populations. Focused on a theme of neuroprotection and adaptation, the SNRP I program approached neuroscience questions from a cellular and molecular perspective. The SNRP II proposal seeks to continue and strengthen this theme by proposing projects that examine neural control at the system, cellular and molecular levels. This SNRP II cooperative agreement proposal is based on the progress achieved by UAF SNRP I over the last 4 years. The successful tenure of 2 neuroscience faculty members and the training provided to other faculty members validates the initial premise that high quality basic research leads to increased opportunities for faculty and students in the neurosciences at UAF. Our four aims provide the framework for the continued growth of the UAF SNRP program: (1) To initiate new research programs strengthening the theme of neuronal adaptation and control at the system, cellular and molecular level. (2) To strengthen the administrative core thereby ensuring a more effective research environment. (3) To emphasize graduate neuroscience education by strengthening the educational infrastructure. (4) To expand undergraduate opportunities for neuroscience research. A new administrative structure consisting of a Scientific Director and Associate Director is proposed to counsel project leaders on proposal development. Outstanding senior scientists will serve as advisors on Program Advisory Committee (PAC) and Scientific Advisory Committee (SAC) to provide recommendations regarding program and research direction. Major projects explore the role of serotonin in homeostasis. The expanded research opportunities offered by SNRP II will stimulate the active participation of Alaska Native students in the projects and will increase the number of Alaskan Native students active in hypothesis-based neuroscience research.