ALASKAN BASIC NEUROSCIENCE PROGRAM

阿拉斯加基础神经科学项目

• 批准号: 6802750
• 负责人: Lawrence K Duffy
• 金额: $ 155.18万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2006-05-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6802750
• 关键词: cooperative study; neuroprotectants; neurosciences; science education

The major objective of the SNRP proposal is to establish an Alaskan Basic Neuroscience Program (ABNP) at the University of Alaska to expand, facilitate and stimulate neuroscience research related to the dramatically increasing health problems of the Alaskan Native population. A second objective is to facilitate the development of collaborative research with scientists at other institutions that can contribute to this effort. A third objective is to stimulate the active participation of Alaskan Native students in the projects of the proposed Program resulting in more Alaskan Native neuroscience students. The ABNP will carry out interdisciplinary research to study mechanisms of neuroprotective adaptations. This will be accomplished by four specific aims: 1) develop an administrative core directly under the Provost that will provide the most effective environment to develop our neuroscientists, 2) develop a research program around the theme of neuroprotective adaptations and increase collaborations with neuroscientists on this theme, 3) develop an emphasis on neuroscience graduate education, and 4) upgrade an existing tissue culture/imaging facility to state-of-the-art standards. An External Advisory Committee composed of experts in the field of neuroscience research will monitor the program. An Internal Advisory Committee will meet to discuss results, future research directions and advice the Program Director on all matters related to the functioning of the ABNP. Neuro protective adaptations in response to stress summarizes the focus of the proposed research. Research will address this theme through a number of hypotheses and interrelated questions focusing on neuroprotective adaptations associated with neuroprotective mechanisms during hibernation and signal transduction in the control of cell death, neuronal regeneration, circadian rhythms and thermoregulation. The results generated by the effort at UAC and the collaborators will be greater than the sum of the individual efforts because of the program's efforts because of the program's impact on the development of a culture of health related research at UAF.

SNRP提案的主要目的是在阿拉斯加大学建立一个阿拉斯加基本神经科学计划（ABNP），以扩大，促进和刺激与阿拉斯加土著人口的健康问题有关的神经科学研究。第二个目标是促进与其他机构的科学家进行合作研究的发展，这可以为这一努力做出贡献。第三个目标是刺激阿拉斯加本地学生在拟议计划的项目中积极参与，从而导致更多的阿拉斯加原住民神经科学学生。 ABNP将进行跨学科研究，以研究神经保护适应的机制。这将通过四个具体目的来完成：1）直接在教务长下建立一个行政核心，该核心将为发展神经科学家提供最有效的环境，2）围绕神经保护适应的主题制定研究计划，并在该主题上与神经科学家的合作提高了这个主题，3）对神经科学研究的培养培养型培养培养物，以及现有的Stancore contral contrave and contrade contrave and contrade contraless contral and-a）。由神经科学研究领域专家组成的外部咨询委员会将监控该计划。一个内部咨询委员会将开会，讨论与ABNP功能有关的所有事项的计划主管的结果，未来的研究指示和建议。响应压力的神经保护适应总结了拟议研究的重点。研究将通过许多假设和相互关联的问题来解决这一主题，该问题的重点是与神经保护机制相关的神经保护适应，在控制细胞死亡，神经元再生，昼夜节律和体温调节的控制过程中和信号转导期间。由于该计划的努力，由于该计划对UAF健康与健康相关研究的发展产生了影响，因此UAC和合作者的努力和合作者所产生的结果将大于个人努力的总和。