ALASKAN BASIC NEUROSCIENCE PROGRAM

SNRP提案的主要目标是在阿拉斯加大学建立阿拉斯加基础神经科学计划(ABNP)，以扩大、促进和刺激与阿拉斯加土著人口日益严重的健康问题相关的神经科学研究。第二个目标是促进与能够为这一努力作出贡献的其他机构的科学家开展合作研究。第三个目标是鼓励阿拉斯加土著学生积极参与拟议方案的项目，从而培养更多的阿拉斯加土著神经科学学生。ABNP将开展跨学科研究，以研究神经保护适应的机制。这将通过四个具体目标来实现：1)建立一个直接隶属于教务长的行政核心，为培养我们的神经科学家提供最有效的环境；2)围绕神经保护适应这一主题制定研究计划，并在这一主题上增加与神经科学家的合作；3)发展对神经科学研究生教育的重视；以及4)将现有的组织培养/成像设施升级到最先进的标准。一个由神经科学研究领域的专家组成的外部咨询委员会将监督该计划。一个内部咨询委员会将开会讨论结果、未来的研究方向以及方案主任就与ABNP运作有关的所有事项提出的建议。应激反应中的神经保护性适应总结了拟议研究的重点。研究将通过一些假设和相关问题来解决这一主题，重点是与冬眠期间的神经保护机制相关的神经保护适应，以及控制细胞死亡、神经元再生、昼夜节律和体温调节的信号转导。UAC和合作者的努力产生的结果将大于个人努力的总和，因为该计划的努力，因为该计划对UAF健康相关研究文化的发展产生了影响。

The major objective of the SNRP proposal is to establish an Alaskan Basic Neuroscience Program (ABNP) at the University of Alaska to expand, facilitate and stimulate neuroscience research related to the dramatically increasing health problems of the Alaskan Native population. A second objective is to facilitate the development of collaborative research with scientists at other institutions that can contribute to this effort. A third objective is to stimulate the active participation of Alaskan Native students in the projects of the proposed Program resulting in more Alaskan Native neuroscience students. The ABNP will carry out interdisciplinary research to study mechanisms of neuroprotective adaptations. This will be accomplished by four specific aims: 1) develop an administrative core directly under the Provost that will provide the most effective environment to develop our neuroscientists, 2) develop a research program around the theme of neuroprotective adaptations and increase collaborations with neuroscientists on this theme, 3) develop an emphasis on neuroscience graduate education, and 4) upgrade an existing tissue culture/imaging facility to state-of-the-art standards. An External Advisory Committee composed of experts in the field of neuroscience research will monitor the program. An Internal Advisory Committee will meet to discuss results, future research directions and advice the Program Director on all matters related to the functioning of the ABNP. Neuro protective adaptations in response to stress summarizes the focus of the proposed research. Research will address this theme through a number of hypotheses and interrelated questions focusing on neuroprotective adaptations associated with neuroprotective mechanisms during hibernation and signal transduction in the control of cell death, neuronal regeneration, circadian rhythms and thermoregulation. The results generated by the effort at UAC and the collaborators will be greater than the sum of the individual efforts because of the program's efforts because of the program's impact on the development of a culture of health related research at UAF.