Advancing UAF SNRP

描述（由申请人提供）：阿拉斯加州与世隔绝和极端的自然条件为阿拉斯加大学费尔班克斯提供了 (UAF)神经科学家及其合作者有机会探索影响健康的各种健康问题 许多独特的阿拉斯加土著和北极人口。专注于神经保护的主题， 为了适应，SNRP I计划从细胞和分子角度探讨神经科学问题， perspective.《第二个国家战略重建方案》的建议旨在继续和加强这一主题，建议的项目 在系统、细胞和分子水平上检查神经控制。SNRP II合作协议 该提案基于UAF SNRP I在过去4年中取得的进展。成功的任期 2名神经科学教员和提供给其他教员的培训验证了最初的 前提是高质量的基础研究导致教师和学生的机会增加 在UAF的神经科学。我们的四个目标为UAF SNRP的持续增长提供了框架 计划：（1）启动新的研究计划，加强神经适应和控制的主题 在系统、细胞和分子水平上。(2)加强行政核心， 更有效的研究环境。(3)强调研究生神经科学教育， 加强教育基础设施建设。(4)扩大神经科学的本科生机会 research. 建议建立一个由科学主任和副主任组成的新的行政结构， 为项目负责人提供有关提案制定的建议。杰出的资深科学家将担任顾问， 项目咨询委员会（PAC）和科学咨询委员会（SAC）提供建议 关于计划和研究方向。主要项目探索血清素在体内平衡中的作用。的 SNRP II提供的更多研究机会将刺激阿拉斯加原住民的积极参与 学生在项目中，并将增加阿拉斯加土著学生的数量积极的假设为基础的 神经科学研究。

Description (provided by applicant): The isolation and extreme natural conditions inherent in Alaska provide University of Alaska Fairbanks (UAF) neuroscientists and their collaborators an opportunity to explore a variety of health issues affecting the many unique Native Alaskan and arctic populations. Focused on a theme of neuroprotection and adaptation, the SNRP I program approached neuroscience questions from a cellular and molecular perspective. The SNRP II proposal seeks to continue and strengthen this theme by proposing projects that examine neural control at the system, cellular and molecular levels. This SNRP II cooperative agreement proposal is based on the progress achieved by UAF SNRP I over the last 4 years. The successful tenure of 2 neuroscience faculty members and the training provided to other faculty members validates the initial premise that high quality basic research leads to increased opportunities for faculty and students in the neurosciences at UAF. Our four aims provide the framework for the continued growth of the UAF SNRP program: (1) To initiate new research programs strengthening the theme of neuronal adaptation and control at the system, cellular and molecular level. (2) To strengthen the administrative core thereby ensuring a more effective research environment. (3) To emphasize graduate neuroscience education by strengthening the educational infrastructure. (4) To expand undergraduate opportunities for neuroscience research. A new administrative structure consisting of a Scientific Director and Associate Director is proposed to counsel project leaders on proposal development. Outstanding senior scientists will serve as advisors on Program Advisory Committee (PAC) and Scientific Advisory Committee (SAC) to provide recommendations regarding program and research direction. Major projects explore the role of serotonin in homeostasis. The expanded research opportunities offered by SNRP II will stimulate the active participation of Alaska Native students in the projects and will increase the number of Alaskan Native students active in hypothesis-based neuroscience research.