THE ANTIHYPERTENSIVE AND LIPID-LOWERING TO PREVENT HEART ATTACK TRIAL RENEWAL

抗高血压和降脂预防心脏病试验续展

• 批准号: 8354777
• 负责人: BARRY DAVIS
• 金额: $ 97.12万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8354777
• 关键词: Ancillary Study; Antihypertensive Agents; Area; Biological Markers; Cessation of life; Cholesterol; Clinical; Clinical Trials; Collaborations; Collection; Communities; Contracts; Data; Data Analyses; Data Collection; Data Set; Development; Epidemiology; Fostering; Future; Hypertension; Hypotension; Information Systems; Institution; International; Kidney; Leadership; Lipids; Manuscripts; Methods; Myocardial Infarction; Outcome; Participant; Pharmacogenetics; Preparation; Research Personnel; Resources; Risk Factors; Science; Scientist; Structure; United States Centers for Medicare and Medicaid Services; United States Social Security Administration; administrative database; base; clinical care; clinical practice; cohort; design; follow-up; indexing; interest; prevent

The Coordinating Center will optimize scientific advancement from the ALLHAT study by using 1) the administrative, data, and analytical resources to support continued manuscript preparation and development of ancillary studies and 2) the ALLHAT governance structure to provide overall scientific leadership. The Coordinating Center will foster scientific contributions based on extensive ALLHAT resources and will expand collaborations with relevant clinical and scientific communities outside of ALLHAT, including development of and collaboration with investigators from academic institutions not recently involved in ALLHAT manuscripts or ancillary studies. Collaborations include scientists with interest in clinical trials, pharmacogenetics, biomarkers, epidemiology, and clinical practice as these interests relate to hypertension and lipid-lowering treatments. This contract will preserve key study resources, continue the passive follow-up of the ALLHAT cohort, expand access to the ALLHAT datasets, and assure open, efficient, and active use of the ALLHAT data by the entire scientific community. ALLHAT participants have been followed since the end of the trial in 2002 through national administrative data bases, including the National Death Index (NDI), Centers for Medicare and Medicaid Services (CMS), United States Renal Data System (USRDS), and Social Security Administration (SSA). The contract renewal will extend the passive follow up for an additional five years through 2016.

协调中心将优化ALLHAT研究的科学进展，使用1)管理、数据和分析资源来支持后续稿件