THE ANTIHYPERTENSIVE AND LIPID-LOWERING TO PREVENT HEART ATTACK TRIAL RENEWAL

抗高血压和降脂预防心脏病试验续展

• 批准号: 8354777
• 负责人: BARRY DAVIS
• 金额: $ 97.12万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8354777
• 关键词: Ancillary Study; Antihypertensive Agents; Area; Biological Markers; Cessation of life; Cholesterol; Clinical; Clinical Trials; Collaborations; Collection; Communities; Contracts; Data; Data Analyses; Data Collection; Data Set; Development; Epidemiology; Fostering; Future; Hypertension; Hypotension; Information Systems; Institution; International; Kidney; Leadership; Lipids; Manuscripts; Methods; Myocardial Infarction; Outcome; Participant; Pharmacogenetics; Preparation; Research Personnel; Resources; Risk Factors; Science; Scientist; Structure; United States Centers for Medicare and Medicaid Services; United States Social Security Administration; administrative database; base; clinical care; clinical practice; cohort; design; follow-up; indexing; interest; prevent

The Coordinating Center will optimize scientific advancement from the ALLHAT study by using 1) the administrative, data, and analytical resources to support continued manuscript preparation and development of ancillary studies and 2) the ALLHAT governance structure to provide overall scientific leadership. The Coordinating Center will foster scientific contributions based on extensive ALLHAT resources and will expand collaborations with relevant clinical and scientific communities outside of ALLHAT, including development of and collaboration with investigators from academic institutions not recently involved in ALLHAT manuscripts or ancillary studies. Collaborations include scientists with interest in clinical trials, pharmacogenetics, biomarkers, epidemiology, and clinical practice as these interests relate to hypertension and lipid-lowering treatments. This contract will preserve key study resources, continue the passive follow-up of the ALLHAT cohort, expand access to the ALLHAT datasets, and assure open, efficient, and active use of the ALLHAT data by the entire scientific community. ALLHAT participants have been followed since the end of the trial in 2002 through national administrative data bases, including the National Death Index (NDI), Centers for Medicare and Medicaid Services (CMS), United States Renal Data System (USRDS), and Social Security Administration (SSA). The contract renewal will extend the passive follow up for an additional five years through 2016.

协调中心将通过使用1）管理、数据和分析资源来支持继续撰写手稿，从而优化ALLHAT研究的科学进展 辅助研究的准备和开发; 2）ALLHAT管理结构，以提供全面的科学领导。协调中心将基于广泛的ALLHAT资源促进科学贡献，并将扩大与ALLHAT以外的相关临床和科学团体的合作，包括开发和与最近未参与ALLHAT手稿或辅助研究的学术机构的研究者合作。合作对象包括对临床试验、药物遗传学、生物标志物、流行病学和临床实践感兴趣的科学家，因为这些兴趣与高血压和降脂治疗有关。该合同将保留关键的研究资源，继续对ALLHAT队列进行被动随访，扩大对ALLHAT数据集的访问，并确保整个科学界开放，有效和积极地使用ALLHAT数据。自2002年试验结束以来，通过国家行政数据库（包括国家死亡指数（NDI）、医疗保险和医疗补助服务中心（CMS）、美国肾脏数据系统（USRDS）和社会保障管理局（SSA））对ALLHAT参与者进行了随访。合同续签将把被动随访延长五年，直至2016年。