THE ANTIHYPERTENSIVE AND LIPID-LOWERING TO PREVENT HEART ATTACK TRIAL RENEWAL

协调中心将通过使用1)管理、数据和分析资源来支持继续手稿，从而优化ALLHAT研究的科学进展 准备和开发辅助研究，以及2)ALLHAT治理结构，以提供全面的科学领导。协调中心将在ALLHAT广泛资源的基础上促进科学贡献，并将扩大与ALLHAT以外的相关临床和科学界的合作，包括发展和与最近未参与ALLHAT手稿或辅助研究的学术机构的研究人员合作。合作的科学家包括对临床试验、药物遗传学、生物标志物、流行病学和临床实践感兴趣的科学家，因为这些兴趣与高血压和降脂治疗有关。这份合同将保留关键的研究资源，继续对ALLHAT队列的被动后续行动，扩大对ALLHAT数据集的访问，并确保整个科学界公开、高效和积极地使用ALLHAT数据。自2002年试验结束以来，ALLHAT参与者一直通过国家行政数据库进行跟踪，包括国家死亡指数(NDI)、医疗保险和医疗补助服务中心(CMS)、美国肾脏数据系统(USRDS)和社会保障管理局(SSA)。续签合同将把被动后续行动再延长五年至2016年。

The Coordinating Center will optimize scientific advancement from the ALLHAT study by using 1) the administrative, data, and analytical resources to support continued manuscript preparation and development of ancillary studies and 2) the ALLHAT governance structure to provide overall scientific leadership. The Coordinating Center will foster scientific contributions based on extensive ALLHAT resources and will expand collaborations with relevant clinical and scientific communities outside of ALLHAT, including development of and collaboration with investigators from academic institutions not recently involved in ALLHAT manuscripts or ancillary studies. Collaborations include scientists with interest in clinical trials, pharmacogenetics, biomarkers, epidemiology, and clinical practice as these interests relate to hypertension and lipid-lowering treatments. This contract will preserve key study resources, continue the passive follow-up of the ALLHAT cohort, expand access to the ALLHAT datasets, and assure open, efficient, and active use of the ALLHAT data by the entire scientific community. ALLHAT participants have been followed since the end of the trial in 2002 through national administrative data bases, including the National Death Index (NDI), Centers for Medicare and Medicaid Services (CMS), United States Renal Data System (USRDS), and Social Security Administration (SSA). The contract renewal will extend the passive follow up for an additional five years through 2016.