Recipient Epidemiology and Donor Evaluation Study III (REDS-III) Domestic Hub

受赠者流行病学和捐助者评估研究 III (REDS-III) 国内中心

• 批准号: 8356112
• 负责人: Edward L Snyder
• 金额: $ 215.76万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-29 至 2013-03-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356112
• 关键词: Adult; Affect; Allogenic; Amendment; Area; Basic Science; Biological Sciences; Blood; Blood Banks; Blood Donations; Blood Transfusion; Cancer Center; Cardiac Surgery procedures; Clinical Research; Clinical Sciences; Collection; Community Hospitals; Confidentiality; Contractor; Contracts; Country; Data; Data Collection; Data Coordinating Center; Data Element; Data Security; Development; Education; Educational Activities; Ensure; Epidemic; Epidemiology; Evaluation Studies; Grant; HIV; Health Insurance Portability and Accountability Act; Health Personnel; Hospitals; Institutional Review Boards; Intensive Care Units; International; Investigation; K-Series Research Career Programs; Knowledge; Laboratories; Laboratory Study; Leadership; Manuals; Medical; Medicine; Mentors; National Heart, Lung, and Blood Institute; Orthopedic Surgery procedures; Outpatients; Participant; Pathologic; Patient Care; Patients; Performance; Policy Developments; Population; Principal Investigator; Procedures; Process; Protocols documentation; Public Health; Publications; Research; Research Activity; Research Methodology; Research Personnel; Risk; Safety; Series; Services; Shipping; Ships; Surveys; System; Training; Training and Education; Transfusion; Translational Research; Trauma; Voting; Work; base; data management; evidence base; evidence based guidelines; improved; meetings; member; oncology; operation; population based; programs; repository; research study; symposium; tertiary care

The objectives of the REDS-III program are to ensure safe and effective blood banking and transfusion medicine practices through a comprehensive, multi-targeted strategy involving basic, translational, and clinical research to improve the benefits of transfusion while reducing its risks. Improving blood component safety and availability in the U.S. and internationally through the conduct of epidemiologic, survey, and laboratory studies is the cornerstone of the REDS program. Transfusion therapy is the most commonly employed, and, arguably, one of the least understood medical procedures in the U.S. affecting about five million recipients annually. This research program is not only critical to public health in the U.S. but also to countries struggling with the HIV epidemic where blood safety and availability are major concerns. The REDS-III program is comprised of one Data Coordinating Center (DCC), one Central Laboratory, four domestic hubs, and three international collaborative programs involving U.S. investigators and investigators at international blood centers. The REDS-III program will target the following blood banking and transfusion medicine areas: donor targeted strategies; blood banking; transfusion practices in adult patients; and education and training.

REDS-III计划的目标是通过涉及基础，转化和临床研究的全面，多目标战略来确保安全有效的血库和输血医学实践，以提高输血的益处，同时降低其风险。通过开展流行病学、调查和实验室研究，提高血液成分在美国和国际上的安全性和可用性是REDS计划的基石。输血治疗是最常用的，也是美国最不了解的医疗程序之一，每年影响约500万接受者。这项研究计划不仅对美国的公共卫生至关重要，而且对那些与艾滋病毒流行作斗争的国家也至关重要，这些国家的血液安全和可用性是主要问题。REDS-III项目由一个数据协调中心（DCC）、一个中心实验室、四个国内中心和三个国际合作项目组成，这些项目涉及美国研究人员和国际血液中心的研究人员。REDS-III计划将针对以下血库和输血医学领域：针对捐助者的战略;血库;成人患者的输血实践;以及教育和培训。