Recipient Epidemiology and Donor Evaluation Study III (REDS-III) Domestic Hub

REDS-III计划的目标是通过涉及基础研究、转化研究和临床研究的全面、多目标战略，确保安全有效的血库和输血医学实践，以提高输血的好处，同时降低其风险。通过进行流行病学、调查和实验室研究来提高美国和国际上血液成分的安全性和可用性是REDS计划的基石。输血疗法是美国最常用的，也是可以说是最不为人所知的医疗程序之一，每年影响大约500万接受治疗的人。这项研究计划不仅对美国的公共卫生至关重要，而且对正在与艾滋病毒疫情作斗争的国家也是如此，在这些国家，血液安全和可获得性是主要问题。REDS-III项目由一个数据协调中心(DCC)、一个中心实验室、四个国内枢纽和三个国际合作项目组成，其中包括美国调查人员和国际血液中心的调查人员。REDS-III计划将针对以下血库和输血医学领域：献血者定向战略；血库；成人患者的输血实践；以及教育和培训。

The objectives of the REDS-III program are to ensure safe and effective blood banking and transfusion medicine practices through a comprehensive, multi-targeted strategy involving basic, translational, and clinical research to improve the benefits of transfusion while reducing its risks. Improving blood component safety and availability in the U.S. and internationally through the conduct of epidemiologic, survey, and laboratory studies is the cornerstone of the REDS program. Transfusion therapy is the most commonly employed, and, arguably, one of the least understood medical procedures in the U.S. affecting about five million recipients annually. This research program is not only critical to public health in the U.S. but also to countries struggling with the HIV epidemic where blood safety and availability are major concerns. The REDS-III program is comprised of one Data Coordinating Center (DCC), one Central Laboratory, four domestic hubs, and three international collaborative programs involving U.S. investigators and investigators at international blood centers. The REDS-III program will target the following blood banking and transfusion medicine areas: donor targeted strategies; blood banking; transfusion practices in adult patients; and education and training.