Recruitment and Screening for the Insight into the Determination of Exceptional

在生命结束时，健康长寿和身体机能良好是大多数人的目标。寻找促进这种情况的方法是国家老龄化研究所（NIA）的一个重要目标。尽管人们已经对长寿和功能衰退之间的关系进行了研究，但我们对为什么有些人能健康地活到80多岁，而另一些人却很快就垮了，所知甚少。换句话说，生理和病理相关因素如何影响寿命和健康老龄化尚不清楚。可以假设，在逃避疾病和残疾的老年人中，体内平衡机制（抗氧化机制的完整性，对大分子的低水平氧化损伤，低炎症，未受损的自主反射，正常的激素水平等）应该相对完整，积累的损伤很少。了解这些机制可能为预防残疾提供新的机会。

Longevity combined with good health and functioning at the end of life is the goal of most individuals. Finding ways of promoting this condition is an important goal of the National Institute on Aging (NIA). Although research has been done on the correlates of long life and functional decline, we still know relatively little about why certain individuals live in excellent health into their 80's while others fail much sooner. In other words, how factors related to physiology and pathology affect longevity and healthy aging is not clear. It may be hypothesized that in older persons who escape diseases and disability, homeostatic mechanisms (integrity of anti-oxidant mechanisms, low level of oxidative damage to macromolecules, low inflammation, unimpaired autonomic reflexes, normal hormone levels etc.) should be relatively intact, with little accumulated damage. Understanding these mechanisms may open new opportunities of disability prevention.